2017
Successful Plerixafor-Mediated Mobilization, Apheresis, and Lentiviral Vector Transduction of Hematopoietic Stem Cells in Patients with Severe Sickle Cell Disease
Tisdale J, Pierciey F, Kamble R, Kanter J, Krishnamurti L, Kwiatkowski J, Thompson A, Shestopalov I, Bonner M, Joseney-Antoine M, Asmal M, Walters M. Successful Plerixafor-Mediated Mobilization, Apheresis, and Lentiviral Vector Transduction of Hematopoietic Stem Cells in Patients with Severe Sickle Cell Disease. Blood 2017, 130: 990. DOI: 10.1182/blood.v130.suppl_1.990.990.Peer-Reviewed Original ResearchSevere sickle cell diseaseSevere SCDPhase 1 studyBM harvestAutologous hematopoietic stem cellsSickle cell diseaseBone marrowBluebird BioHematopoietic stem cellsCell diseaseCultured CD34Cells/G-CSFPeak white blood cellAdvisory CommitteeMedical directorsHSC mobilizationGene therapyGrade 3 AEsPeripheral blood apheresisGroup B patientsAcceptable toxicity profileLife-threatening complicationsTotal blood volumeSteady-state bone marrow
2006
Acute renal failure from xanthine nephropathy during management of acute leukemia
LaRosa C, McMullen L, Bakdash S, Ellis D, Krishnamurti L, Wu H, Moritz M. Acute renal failure from xanthine nephropathy during management of acute leukemia. Pediatric Nephrology 2006, 22: 132-135. PMID: 17039332, DOI: 10.1007/s00467-006-0287-z.Peer-Reviewed Original ResearchConceptsTumor lysis syndromeAcute renal failureLysis syndromeXanthine nephropathyRenal failureTumor lysis syndrome prophylaxisOliguric acute renal failureT-cell acute lymphoblastic leukemiaLife-threatening complicationsAcute lymphoblastic leukemiaDiagnosis of patientsAggressive chemotherapyInduction chemotherapyUrinary xanthineUrine alkalinizationSerious complicationsLymphoproliferative malignanciesLymphoblastic leukemiaAcute leukemiaUrine measurementsPreemptive useNephropathyUric acid synthesisSyndromeHypoxanthine levelsElevation of tricuspid regurgitant jet velocity, a marker for pulmonary hypertension in children with sickle cell disease
Ambrusko S, Gunawardena S, Sakara A, Windsor B, Lanford L, Michelson P, Krishnamurti L. Elevation of tricuspid regurgitant jet velocity, a marker for pulmonary hypertension in children with sickle cell disease. Pediatric Blood & Cancer 2006, 47: 907-913. PMID: 16496290, DOI: 10.1002/pbc.20791.Peer-Reviewed Original ResearchConceptsElevated tricuspid regurgitant velocityTricuspid regurgitant velocitySickle cell diseaseAcute chest syndromePulmonary hypertensionCerebrovascular diseaseVasoocclusive crisisSCD patientsReticulocyte countCell diseaseType of SCDTricuspid regurgitant jet velocityLife-threatening complicationsObstructive sleep apneaPediatric SCD patientsRegurgitant jet velocityElevated reticulocyte countSignificant differencesNumber of echocardiogramsChest syndromeEchocardiographic evidenceOutpatient echocardiogramMean hemoglobinClinical characteristicsHydroxyurea therapy