2024
Reproductive Health Assessment and Reports of Fertility Counseling in Pediatric and Adolescent Patients with Sickle Cell Disease After Hematopoietic Cell Transplantation
George S, Veludhandi A, Xiang Y, Liu K, Stenger E, Arnold S, Mehta A, Schirmer D, Spencer J, Guilcher G, Bhatia M, Abraham A, Gomez-Lobo V, Krishnamurti L, Meacham L. Reproductive Health Assessment and Reports of Fertility Counseling in Pediatric and Adolescent Patients with Sickle Cell Disease After Hematopoietic Cell Transplantation. Transplantation And Cellular Therapy 2024, 30: 912.e1-912.e13. PMID: 38972510, PMCID: PMC11344653, DOI: 10.1016/j.jtct.2024.06.029.Peer-Reviewed Original ResearchHematopoietic cell transplantationSickle cell diseaseFollicle-stimulating hormone levelsPost-HCTParent-proxyConditioning regimensCell transplantationFertility counselingHormone levelsCell diseaseCyclophosphamide equivalent doseSickle cell disease patientsPremature ovarian insufficiencyElevated FSH levelsDiminished ovarian reserveAnti-Mullerian hormone levelsBone marrow stem cellsEffective method of educationGonadal hormone productionHealth Survey dataReproductive health assessmentReproductive health issuesMarrow stem cellsSibling donorOvarian insufficiency
2023
Female Reproductive Health Outcomes after Hematopoietic Cell Transplantation for Sickle Cell Disease: Is Reduced Intensity Better Than Myeloablative Conditioning?
Meacham L, George S, Veludhandi A, Pruett M, Haight A, Arnold S, Elchuri S, Stenger E, Krishnamurti L. Female Reproductive Health Outcomes after Hematopoietic Cell Transplantation for Sickle Cell Disease: Is Reduced Intensity Better Than Myeloablative Conditioning? Transplantation And Cellular Therapy 2023, 29: 531.e1-531.e4. PMID: 37169288, DOI: 10.1016/j.jtct.2023.05.004.Peer-Reviewed Original ResearchConceptsHematopoietic cell transplantationReduced-intensity conditioningPremature ovarian insufficiencySickle cell diseaseNormal AMH levelsMyeloablative conditioningAnti-Müllerian hormoneOvarian outcomeAMH levelsCell transplantationCell diseaseRIC HCTFollicle-stimulating hormone levelsPediatric oncology patientsRisk of infertilityMIU/mLStudy 2 patientsReproductive health outcomesMelphalan regimenConditioning regimenGonadal damageOvarian damageConditioning regimensOvarian reserveRIC regimens