2020
Primary caregiver decision‐making in hematopoietic cell transplantation and gene therapy for sickle cell disease
Sinha C, Bakshi N, Ross D, Loewenstein G, Krishnamurti L. Primary caregiver decision‐making in hematopoietic cell transplantation and gene therapy for sickle cell disease. Pediatric Blood & Cancer 2020, 68: e28749-e28749. PMID: 33034129, PMCID: PMC8246626, DOI: 10.1002/pbc.28749.Peer-Reviewed Original ResearchConceptsHematopoietic cell transplantationSickle cell diseasePrimary caregiversSCD complicationsCell transplantationCell diseaseDiminished qualityAutologous hematopoietic progenitor cellsPrimary caregiver reportMajor medical decisionsGene therapyCurative optionSevere complicationsHematopoietic progenitor cellsClinical trialsAcceptable treatmentRecent complicationsComplicationsCaregiver reportsCaregiversProgenitor cellsNormal lifeTransplantationTherapyMedical decisions
2016
Haematopoietic stem cell transplantation for sickle cell disease – current practice and new approaches
Arnold S, Bhatia M, Horan J, Krishnamurti L. Haematopoietic stem cell transplantation for sickle cell disease – current practice and new approaches. British Journal Of Haematology 2016, 174: 515-525. PMID: 27255787, DOI: 10.1111/bjh.14167.Peer-Reviewed Original ResearchConceptsHaematopoietic stem cell transplantSickle cell diseaseCell diseaseAllogeneic haematopoietic stem cell transplantOnly available curative therapyHaematopoietic stem cell transplantationAlternative donor transplantsAvailable curative therapyCurrent maintenance therapiesTransplant-related mortalityDisease-free survivalIncidence of rejectionStem cell transplantStem cell transplantationHuman leucocyte antigenPool of donorsComplications persistHaploidentical donorsMaintenance therapyConditioning regimensCurative optionDonor transplantsSibling transplantsSupportive careCurative therapy
2010
Hematopoietic Stem Cell Transplantation for Hemoglobinopathies: Current Practice and Emerging Trends
Smiers F, Krishnamurti L, Lucarelli G. Hematopoietic Stem Cell Transplantation for Hemoglobinopathies: Current Practice and Emerging Trends. Pediatric Clinics Of North America 2010, 57: 181-205. PMID: 20307718, DOI: 10.1016/j.pcl.2010.01.003.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationStem cell transplantationCell transplantationNew conditioning regimensTreatment-related toxicityOnly curative optionNumber of patientsManagement of thalassemiaSickle cell diseaseConditioning regimensCurative optionTreatment complicationsDonor poolCell diseasePatientsLife expectancyTransplantationHemoglobinopathiesCurrent practiceRegimensComplications
2007
HEMATOPOIETIC CELL TRANSPLANTATION: A Curative Option for Sickle Cell Disease
Krishnamurti L. HEMATOPOIETIC CELL TRANSPLANTATION: A Curative Option for Sickle Cell Disease. Pediatric Hematology And Oncology 2007, 24: 569-575. PMID: 18092247, DOI: 10.1080/08880010701640531.Peer-Reviewed Original ResearchConceptsSickle cell diseaseCell transplantationCell diseaseReduced intensity conditioning regimenIndication of transplantationHematopoietic cell transplantationImpact of transplantationIntensity conditioning regimenStem cell transplantationPossibility of cureEffect of treatmentConditioning regimenPreparative regimenPulmonary hypertensionCurative optionBlood transfusionConsiderable morbidityPediatric patientsRelated morbidityOrgan damagePremature mortalityTransplantationNatural historyMorbidityRegimen
2003
Availability of unrelated donors for hematopoietic stem cell transplantation for hemoglobinopathies
Krishnamurti L, Abel S, Maiers M, Flesch S. Availability of unrelated donors for hematopoietic stem cell transplantation for hemoglobinopathies. Bone Marrow Transplantation 2003, 31: 547-550. PMID: 12692619, DOI: 10.1038/sj.bmt.1703887.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationNational Marrow Donor ProgramStem cell transplantationUnrelated donorsHemoglobinopathy patientsCell transplantationThalassemia patientsURD HSCTLife-threatening blood diseaseSickle cell disease patientsUnrelated bone marrow donorsUmbilical cord blood unitsHLA-identical siblingsOnly curative optionCord blood unitsBone marrow donorsCurative optionPreparative regimensHLA matchDisease patientsPotential HLAMarrow donorsNMDP RegistryPatientsVolunteer donors