2020
Primary caregiver decision‐making in hematopoietic cell transplantation and gene therapy for sickle cell disease
Sinha C, Bakshi N, Ross D, Loewenstein G, Krishnamurti L. Primary caregiver decision‐making in hematopoietic cell transplantation and gene therapy for sickle cell disease. Pediatric Blood & Cancer 2020, 68: e28749-e28749. PMID: 33034129, PMCID: PMC8246626, DOI: 10.1002/pbc.28749.Peer-Reviewed Original ResearchConceptsHematopoietic cell transplantationSickle cell diseasePrimary caregiversSCD complicationsCell transplantationCell diseaseDiminished qualityAutologous hematopoietic progenitor cellsPrimary caregiver reportMajor medical decisionsGene therapyCurative optionSevere complicationsHematopoietic progenitor cellsClinical trialsAcceptable treatmentRecent complicationsComplicationsCaregiver reportsCaregiversProgenitor cellsNormal lifeTransplantationTherapyMedical decisionsPatient and family experience with chronic transfusion therapy for sickle cell disease: A qualitative study
Hawkins L, Sinha C, Ross D, Yee M, Quarmyne M, Krishnamurti L, Bakshi N. Patient and family experience with chronic transfusion therapy for sickle cell disease: A qualitative study. BMC Pediatrics 2020, 20: 172. PMID: 32305060, PMCID: PMC7165370, DOI: 10.1186/s12887-020-02078-w.Peer-Reviewed Original ResearchConceptsChronic transfusion therapySickle cell diseaseTransfusion therapyCell diseaseHealthcare providersPrevention of complicationsFamily experiencesStroke preventionVenous accessPatient knowledgeChildren 12Future studiesPatient participantsChelation therapySignificant patientFamily burdenSubstantial burdenPatient experiencePatientsSemi-structured interview formatTherapyComplicationsResultsFour themesBurdenInformed decision-making process
2018
Sickle cell disease
Kato G, Piel F, Reid C, Gaston M, Ohene-Frempong K, Krishnamurti L, Smith W, Panepinto J, Weatherall D, Costa F, Vichinsky E. Sickle cell disease. Nature Reviews Disease Primers 2018, 4: 18010. PMID: 29542687, DOI: 10.1038/nrdp.2018.10.Peer-Reviewed Original ResearchConceptsSickle cell diseaseCell diseaseHaematopoietic stem cell transplantationAcute pain eventsAcute chest syndromeHigh-burden settingsStem cell transplantationCommon acute complicationHemoglobin subunit βNewborn screening programsUniversal newborn screening (NBS) programsChest syndromeAcute complicationsChronic complicationsBlood transfusionCell transplantationPathophysiological mechanismsPain eventsScreening programEarly diagnosisSCD phenotypeImmune systemΒ-globin subunitDiseaseComplications
2016
Clinical events in a large prospective cohort of children with sickle cell disease in Nagpur, India: evidence against a milder clinical phenotype in India
Jain D, Arjunan A, Sarathi V, Jain H, Bhandarwar A, Vuga M, Krishnamurti L. Clinical events in a large prospective cohort of children with sickle cell disease in Nagpur, India: evidence against a milder clinical phenotype in India. Pediatric Blood & Cancer 2016, 63: 1814-1821. PMID: 27279568, DOI: 10.1002/pbc.26085.Peer-Reviewed Original ResearchConceptsSickle cell diseaseRate of painAcute chest syndromeRate of complicationsNewborn screenCell diseaseChest syndromeFrequent complicationSevere anemiaSplenic sequestrationClinical phenotypeLarge single-center studyMore frequent complicationsSingle-center studyLarge prospective cohortPediatric SCD patientsPhenotypes of SCDMilder clinical phenotypeProspective cohortSCD patientsClinical eventsComplicationsSCD phenotypeCooperative StudyEvent rates
2013
First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno‐Occlusive Disease
George M, Novelli E, Shigemura N, Simon M, Feingold B, Krishnamurti L, Morrell M, Gries C, Haider S, Johnson B, Crespo M, Bhama J, Bermudez C, Yousem S, Toyoda Y, Champion H, Pilewski J, Gladwin M. First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno‐Occlusive Disease. Pulmonary Circulation 2013, 3: 952-958. PMID: 25006411, PMCID: PMC4070828, DOI: 10.1086/674749.Peer-Reviewed Original ResearchPulmonary veno-occlusive diseaseVeno-occlusive diseasePulmonary arterial hypertensionLung transplantationArterial hypertensionFirst successful lung transplantationSevere pulmonary arterial hypertensionBilateral lung transplantationPulmonary vascular complicationsSuccessful lung transplantSuccessful lung transplantationSickle cell diseaseFirst successful outcomeLung transplantVascular complicationsPathological dataMultidisciplinary planningCell diseaseTransplantationSuccessful outcomePatientsDiseaseHypertensionFirst caseComplications
2010
Hematopoietic Stem Cell Transplantation for Hemoglobinopathies: Current Practice and Emerging Trends
Smiers F, Krishnamurti L, Lucarelli G. Hematopoietic Stem Cell Transplantation for Hemoglobinopathies: Current Practice and Emerging Trends. Pediatric Clinics Of North America 2010, 57: 181-205. PMID: 20307718, DOI: 10.1016/j.pcl.2010.01.003.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationStem cell transplantationCell transplantationNew conditioning regimensTreatment-related toxicityOnly curative optionNumber of patientsManagement of thalassemiaSickle cell diseaseConditioning regimensCurative optionTreatment complicationsDonor poolCell diseasePatientsLife expectancyTransplantationHemoglobinopathiesCurrent practiceRegimensComplications