2020
Mortality in sickle cell disease: A population‐based study in an aboriginal community in the Gudalur Valley, Nilgiris, Tamil Nadu, India
Sheshadri V, Shabeer P, Santhirapala V, Jayaram A, Krishnamurti L, Menon N. Mortality in sickle cell disease: A population‐based study in an aboriginal community in the Gudalur Valley, Nilgiris, Tamil Nadu, India. Pediatric Blood & Cancer 2020, 68: e28875. PMID: 33381914, DOI: 10.1002/pbc.28875.Peer-Reviewed Original ResearchConceptsSickle cell diseaseCause of deathCell diseaseMortality rateSeverity of SCDAge groupsAboriginal populationAcute chest syndromePopulation-based studyPercent of deathsCrude mortality rateCommunity-based comprehensive careCause of mortalityCases of deathPaucity of dataCommon monogenic disorderChest syndromeMedian ageHospital recordsSCD patientsAutopsy questionnaireAboriginal communitiesComprehensive careLongitudinal cohortRemote Aboriginal communities
2018
From trust to skepticism: An in-depth analysis across age groups of adults with sickle cell disease on their perspectives regarding hydroxyurea
Sinha C, Bakshi N, Ross D, Krishnamurti L. From trust to skepticism: An in-depth analysis across age groups of adults with sickle cell disease on their perspectives regarding hydroxyurea. PLOS ONE 2018, 13: e0199375. PMID: 29949647, PMCID: PMC6021071, DOI: 10.1371/journal.pone.0199375.Peer-Reviewed Original ResearchConceptsSickle cell diseaseGroup 1 participantsGroup 2 participantsCell diseaseSide effectsAdult SCD patientsPatient-related factorsPotential side effectsAdult patientsSCD patientsHU usePatients' attitudesAge 31Age groupsAge 18PatientsYoung adultsEfficacySignificant differencesAdultsEffective alternativeDiseaseRiskParticipantsQualitative interviews
2014
Pan-Selectin Antagonist Rivipansel (GMI-1070) Reduces Soluble E-Selectin Levels While Improving Clinical Outcomes in SCD Vaso-Occlusive Crisis
Wun T, Telen M, Krishnamurti L, McCavit T, DeCastro L, Flanner H, Kuypers F, Larkin S, Rhee S, Magnani J, Thackray H. Pan-Selectin Antagonist Rivipansel (GMI-1070) Reduces Soluble E-Selectin Levels While Improving Clinical Outcomes in SCD Vaso-Occlusive Crisis. Blood 2014, 124: 2704. DOI: 10.1182/blood.v124.21.2704.2704.Peer-Reviewed Original ResearchSoluble E-selectin levelsPhase 2 trialVaso-occlusive crisisSE-selE-selectin levelsClinical outcomesAdhesion molecule-1Placebo groupLast doseSubgroup analysisE-selectinMolecule-1Sickle cell disease vaso-occlusive crisisDouble-blind phase 2 trialSoluble adhesion molecules E-selectinBaseline white blood cell countRandomized phase 2 studySCD vaso-occlusive crisisSoluble adhesion molecule concentrationsAge groupsVascular cell adhesion molecule-1White blood cell countIntercellular adhesion molecule-1Adhesion molecules E-selectinCell adhesion molecule-1
2010
Changing Age Distribution of Deep Venous Thrombosis In the United States
Viswanathan P, Krishnamurti L. Changing Age Distribution of Deep Venous Thrombosis In the United States. Blood 2010, 116: 1539. DOI: 10.1182/blood.v116.21.1539.1539.Peer-Reviewed Original ResearchDeep vein thrombosisNational Inpatient SampleDistribution of DVTDifferent age groupsPrincipal diagnosisHospitalized populationAge groupsPulmonary embolismSecondary diagnosisEpidemiology of hospitalizationsDeep venous thrombosisAge group 45Time of admissionICD-9 codesYears of agePublic health importanceAge distributionVein thrombosisHospitalized patientsVenous thrombosisGroup 45Total populationInpatient SampleHealth care researchNational utilizationBurden of In-Hospital Care of Thrombotic Microangiopathies In the United States
Gupta A, Krishnamurti L. Burden of In-Hospital Care of Thrombotic Microangiopathies In the United States. Blood 2010, 116: 2559. DOI: 10.1182/blood.v116.21.2559.2559.Peer-Reviewed Original ResearchNationwide Inpatient SampleThrombotic microangiopathyHealth care utilizationRelated hospital admissionsHealthcare utilizationHospital dischargeHospital admissionCare utilizationHospital chargesTherapeutic plasmapheresisAge groupsFrequent healthcare encountersIn-Hospital CarePayer inpatient databaseClinical Modification codesAverage hospital chargesBurden of careNational dataFirst national dataStratified probability sampleU.S. community hospitalsTotal hospitalizationsFrequent hospitalizationsInpatient DatabaseMean duration
2009
Current Epidemiology and Hospitalization Characteristics for Acute Chest Syndrome: A Nationally Representative Survey.
Goel R, Viswanathan P, Krishnamurti L. Current Epidemiology and Hospitalization Characteristics for Acute Chest Syndrome: A Nationally Representative Survey. Blood 2009, 114: 4608. DOI: 10.1182/blood.v114.22.4608.4608.Peer-Reviewed Original ResearchAcute chest syndromeSickle cell diseaseSCD patientsChest syndromeHospital mortalityHospital dischargeCommon complicationRelated hospitalizationsExchange transfusionMechanical ventilationDischarge diagnosisAge groupsICD-9-CM diagnosis codesNationwide Inpatient Sample databaseHigher hospital chargesMean lengthCost of hospitalizationYears age groupMajority of deathsCause of mortalityHigher mean chargesNationally Representative SurveyStratified probability sampleHealth care qualityU.S. community hospitals