Spironolactone inhibits the activity of the Na+/H+ exchanger in the aorta of mineralocorticoid-induced hypertensive rats
Carreño JE, Verdugo FJ, Contreras F, Montellano FA, Veloso S, Schalper KA, Sandoval M, Villanueva S, Marusic E, Irarrazabal CE. Spironolactone inhibits the activity of the Na+/H+ exchanger in the aorta of mineralocorticoid-induced hypertensive rats. Journal Of The Renin-Angiotensin-Aldosterone System 2015, 16: 1225-1231. PMID: 25997821, DOI: 10.1177/1470320315587193.Peer-Reviewed Original ResearchConceptsNHE-1 activityMineralocorticoid receptor activationEthyl isopropyl amilorideVascular contractilityHypertensive ratsReceptor activationMale Sprague-Dawley ratsUninephrectomized male Sprague-Dawley ratsChronic DOCA treatmentDiastolic blood pressureAortic wall thicknessWeeks of treatmentVascular smooth muscle cellsProtein levelsSprague-Dawley ratsSmooth muscle cellsNHE-1 mRNADOCA treatmentBlood pressureDOCA administrationExchanger isoform 1Rat aortaDOCA groupSpironolactoneAorta