Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada
Weichenthal S, Lavigne E, You H, Pollitt K, Shin T, Kulka R, Stieb D, Hatzopoulou M, Evans G, Burnett R. Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM2.5 Oxidative Potential on Observed Associations Across Canada. Epidemiology 2023, 34: 897-905. PMID: 37732880, DOI: 10.1097/ede.0000000000001651.Peer-Reviewed Original ResearchConceptsIschaemic heart disease eventsHeart disease eventsAcute cardiovascular eventsCardiovascular eventsDisease eventsOdds ratioPotential time-varying confoundersAcute cardiovascular effectsFine particulate air pollutionCase-crossover studyOutdoor fine particulate air pollutionHealth impactsCardiovascular health impactsParticulate air pollutionCardiovascular effectsHighest tertileTime-varying confoundersOlder subjectsHospitalizationObserved associationsOxidative stressOxidative potentialPM2.5 oxidative potentialMonthsAssociationWithin-city spatial variations in long-term average outdoor oxidant gas concentrations and cardiovascular mortality: Effect modification by oxidative potential in the Canadian Census Health and Environment Cohort
Ripley S, Gao D, Pollitt K, Lakey P, Shiraiwa M, Hatzopoulou M, Weichenthal S. Within-city spatial variations in long-term average outdoor oxidant gas concentrations and cardiovascular mortality: Effect modification by oxidative potential in the Canadian Census Health and Environment Cohort. Environmental Epidemiology 2023, 7: e257. PMID: 37545813, PMCID: PMC10403014, DOI: 10.1097/ee9.0000000000000257.Peer-Reviewed Original ResearchCanadian Census HealthCardiovascular mortalityReactive oxygen species concentrationParticulate air pollutionEnvironment CohortMeasures of PMRetrospective cohort studyFine particulate air pollutionRelevant confounding factorsProportional hazards modelOutdoor fine particulate air pollutionPopulation health impactHealth impactsCardiovascular health impactsOutdoor air pollutionCardiovascular deathCohort studyOxidant gasesEffect modificationHazards modelConfounding factorsMortalityOxidative stressHealth effectsOxidative potential