2000
Mechanism of muscle glycogen autoregulation in humans
Laurent D, Hundal R, Dresner A, Price T, Vogel S, Petersen K, Shulman G. Mechanism of muscle glycogen autoregulation in humans. AJP Endocrinology And Metabolism 2000, 278: e663-e668. PMID: 10751200, DOI: 10.1152/ajpendo.2000.278.4.e663.Peer-Reviewed Original ResearchConceptsInsulin-stimulated ratesWhole body glucose oxidation ratesMuscle glycogenGlycogen loadingPlasma free fatty acid concentrationsWhole-body glucose uptakeFree fatty acid concentrationsMuscle glycogen contentGlucose oxidation ratesMuscle glycogen synthesisPlasma lactate concentrationTwofold increaseHyperinsulinemic clampGlycogen synthase activityFatty acid concentrationsLoading protocolGlucose infusionHealthy volunteersLactate concentrationGlycogen contentGlucose uptakeAnaerobic glycolysisGlycogen synthesisUnlabeled glucose infusionGlycogenIntramuscular Glycogen and Intramyocellular Lipid Utilization during Prolonged Exercise and Recovery in Man: A 13C and 1H Nuclear Magnetic Resonance Spectroscopy Study1
Krssak M, Petersen K, Bergeron R, Price T, Laurent D, Rothman D, Roden M, Shulman G. Intramuscular Glycogen and Intramyocellular Lipid Utilization during Prolonged Exercise and Recovery in Man: A 13C and 1H Nuclear Magnetic Resonance Spectroscopy Study1. The Journal Of Clinical Endocrinology & Metabolism 2000, 85: 748-754. PMID: 10690886, DOI: 10.1210/jcem.85.2.6354.Peer-Reviewed Original ResearchProlonged exerciseIMCL contentGlycogen contentBaseline valuesSoleus muscleMuscle glycogenMuscle groupsGreater muscle glycogen utilizationForearm musclesGlycogen concentrationLipid utilizationIntramyocellular lipid poolMuscle glycogen utilizationCalf muscle groupThigh muscle groupsIntramyocellular glycogenNonexercising muscleIntramuscular glycogenGlycogen depletionGlycogen utilizationTime of exhaustionLeg musclesThigh musclesSubmaximal intensitiesMuscle
1998
EFFECTIVENESS OF TWO CARBOHYDRATE LOADING PROTOCOLS TO ACHIEVE AND MAINTAIN SUPERCOMPENSATED MUSCLE GLYCOGEN
Goforth H, Schneider K, Prusaczyk W, Laurent D, Petersen K, Shulman G. EFFECTIVENESS OF TWO CARBOHYDRATE LOADING PROTOCOLS TO ACHIEVE AND MAINTAIN SUPERCOMPENSATED MUSCLE GLYCOGEN. Medicine & Science In Sports & Exercise 1998, 30: 246. DOI: 10.1097/00005768-199805001-01401.Peer-Reviewed Original ResearchMuscle glycogenLoading protocolEffect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans
Laurent D, Petersen K, Russell R, Cline G, Shulman G. Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans. American Journal Of Physiology 1998, 274: e130-e138. PMID: 9458758, DOI: 10.1152/ajpendo.1998.274.1.e130.Peer-Reviewed Original ResearchConceptsInsulin-stimulated muscle glycogen synthesisMuscle glycogen synthesisMuscle glycogenolysisEpinephrine infusionPhysiological increaseWhole-body glucose oxidationMuscle glycogen synthesis ratesPlasma epinephrine concentrationEuglycemic hyperinsulinemic clampGlucose infusion rateEffect of epinephrineGlycogen synthesisInsulin-stimulated glycogenesisBasal insulinControl subjectsPlasma glucoseEpinephrine concentrationsFree fatty acidsBasal valuesInfusion rateGlycogen synthesis rateMuscle glycogenEpinephrineGlycogenolysisMajor impairment