2016
Expression of cFLIPL Determines the Basal Interaction of Bcl‐2 With Beclin‐1 and Regulates p53 Dependent Ubiquitination of Beclin‐1 During Autophagic Stress
Ranjan K, Pathak C. Expression of cFLIPL Determines the Basal Interaction of Bcl‐2 With Beclin‐1 and Regulates p53 Dependent Ubiquitination of Beclin‐1 During Autophagic Stress. Journal Of Cellular Biochemistry 2016, 117: 1757-1768. PMID: 26682748, DOI: 10.1002/jcb.25474.Peer-Reviewed Original ResearchConceptsAutophagic stressDependent ubiquitinationBeclin-1Bcl-2Cell deathExpression of cFLIPLCo-immunoprecipitation analysisRegulation of autophagyHEK 293T cellsDifferent physiological processesAnti-apoptotic proteinsCellular homeostasisCellular stressEctopic expressionKnockdown cellsJNK1 activationCanonical interactionsProtein HMGB1Physiological processesBasal interactionCFLIPLSelective knockdownUbiquitinationAutophagyH2 O2
2013
Regulation of HA14‐1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells
Ranjan K, Sharma A, Surolia A, Pathak C. Regulation of HA14‐1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells. BioFactors 2013, 40: 157-169. PMID: 23559532, DOI: 10.1002/biof.1098.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisAutophagyBenzopyransCaspase 3CatalaseCell ProliferationCell SurvivalCurcuminDrug Resistance, NeoplasmDrug SynergismHEK293 CellsHumansMembrane Potential, MitochondrialNitrilesOxidative StressProto-Oncogene Proteins c-bcl-2Reactive Oxygen SpeciesSuperoxide DismutaseTranscription Factor RelAConceptsHuman embryonic kidney cellsHA14-1Embryonic kidney cellsProcess of autophagyHEK 293T cellsOxidative stressAntiapoptotic protein Bcl-2Kidney cellsProtein Bcl-2Toxic responsePromotion of malignancyAugmentation of apoptosisGeneration of ROSSignaling mechanismAntiapoptotic proteinsCell deathCancerous cell linesApoptotic activityCell proliferationBcl-2Cell linesPathological consequencesROS generationApoptosisROS