2022
Polypharmacy and medical intensive care unit (MICU) admission and 10-year all-cause mortality risk among hospitalized patients with and without HIV
Gordon KS, Crothers K, Butt AA, Edelman EJ, Gibert C, Pisani MM, Rodriguez-Barradas M, Wyatt C, Justice AC, Akgün KM. Polypharmacy and medical intensive care unit (MICU) admission and 10-year all-cause mortality risk among hospitalized patients with and without HIV. PLOS ONE 2022, 17: e0276769. PMID: 36302039, PMCID: PMC9612570, DOI: 10.1371/journal.pone.0276769.Peer-Reviewed Original ResearchConceptsMedical intensive care unit admissionIntensive care unit admissionCare unit admissionMICU admissionSeverity of illnessHazard ratioHIV statusUnit admissionCause mortalityHospitalized patientsElectronic health record cohortLevel of polypharmacyRetrospective cohort studyCause mortality riskCohort studyHIV infectionCox regressionPolypharmacyMortality riskFiscal year 2009AdmissionPatientsMortalitySubstance useStrong association
2020
Are we missing opioid-related deaths among people with HIV?
Becker WC, Gordon KS, Edelman EJ, Goulet JL, Kerns RD, Marshall BDL, Fiellin DA, Justice AC, Tate JP. Are we missing opioid-related deaths among people with HIV? Drug And Alcohol Dependence 2020, 212: 108003. PMID: 32417360, PMCID: PMC9580216, DOI: 10.1016/j.drugalcdep.2020.108003.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyOpioid useOverdose deathsLife-limiting conditionsUnnatural deathsGreater oddsAging Cohort StudyVACS IndexOpioid exposureCohort studyHIV infectionHIV statusRisk factorsOdds ratioDeath filesIndex causeHIVDisease severityDeathDecedentsIllicit useDifferential misclassificationOddsCauseOpioids
2016
Immunological and infectious risk factors for lung cancer in US veterans with HIV: a longitudinal cohort study
Sigel K, Wisnivesky J, Crothers K, Gordon K, Brown ST, Rimland D, Rodriguez-Barradas MC, Gibert C, Goetz MB, Bedimo R, Park LS, Dubrow R. Immunological and infectious risk factors for lung cancer in US veterans with HIV: a longitudinal cohort study. The Lancet HIV 2016, 4: e67-e73. PMID: 27916584, PMCID: PMC5444465, DOI: 10.1016/s2352-3018(16)30215-6.Peer-Reviewed Original ResearchConceptsCD4/CD8 ratioBacterial pneumonia episodesLung cancerCD8 ratioPneumonia episodesCohort studyHIV infectionUse disordersCumulative exposureLower CD4/CD8 ratioLow CD4 cell countsHepatitis C virus infectionVeterans Aging Cohort StudyChronic obstructive pulmonary diseaseAntiretroviral therapy eraAverage cumulative exposureDysfunctional immune activationHIV RNA concentrationIncident lung cancerLarge HIV cohortC virus infectionCD4 cell countObstructive pulmonary diseaseAging Cohort StudyInfectious risk factorsComparative Effectiveness of Diabetic Oral Medications Among HIV-Infected and HIV-Uninfected Veterans
Han JH, Gordon K, Womack JA, Gibert CL, Leaf DA, Rimland D, Rodriguez-Barradas MC, Bisson GP. Comparative Effectiveness of Diabetic Oral Medications Among HIV-Infected and HIV-Uninfected Veterans. Diabetes Care 2016, 40: 218-225. PMID: 27634393, PMCID: PMC5250696, DOI: 10.2337/dc16-0718.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanBlood GlucoseBody Mass IndexComparative Effectiveness ResearchDiabetes Mellitus, Type 2FemaleFollow-Up StudiesGlycated HemoglobinHispanic or LatinoHIV InfectionsHumansHypoglycemic AgentsLongitudinal StudiesMaleMetforminMiddle AgedSulfonylurea CompoundsThiazolidinedionesVeteransWhite PeopleConceptsType 2 diabetesDiabetic medicationsHIV infectionHispanic patientsPoor responseGlycemic responseOral diabetic medicationsLongitudinal cohort studyBaseline HbAGlycemic effectivenessHIV-InfectedUninfected veteransMedication initiationCohort studyOral medicationsWhite patientsPotential confoundersClinical covariatesMedicationsHIVPatientsType 2Comparative effectivenessPropensity scoreDiabetes
2015
Individual and Neighborhood Characteristics Associated with HIV Among Black and Latino Adults Who Use Drugs and Unaware of Their HIV-Positive Status, New York City, 2000–2004
Lewis CF, Rivera AV, Crawford ND, Gordon K, White K, Vlahov D, Galea S. Individual and Neighborhood Characteristics Associated with HIV Among Black and Latino Adults Who Use Drugs and Unaware of Their HIV-Positive Status, New York City, 2000–2004. Journal Of Racial And Ethnic Health Disparities 2015, 3: 573-581. PMID: 27294761, DOI: 10.1007/s40615-015-0176-x.Peer-Reviewed Original ResearchConceptsStudy enrollmentNegative HIV statusHIV-positive statusInterviewer-administered surveyIllicit drug usePersistent racial disparitiesHigher proportionHIV infectionHIV-positiveHIV statusNeighborhood socioeconomic contextHIV preventionHIVLatino adultsDrug useRisk behaviorsTreatment effortsBlack residentsRacial disparitiesLatino individualsDrugsLess deprivationBlack individualsCharacteristics AssociatedNeighborhood social context
2014
Sexual Partner Notification of HIV Infection Among a National United States-Based Sample of HIV-Infected Men
Edelman EJ, Gordon KS, Hogben M, Crystal S, Bryant K, Justice AC, Fiellin DA, for the VACS Project Team. Sexual Partner Notification of HIV Infection Among a National United States-Based Sample of HIV-Infected Men. AIDS And Behavior 2014, 18: 1898-1903. PMID: 24858394, PMCID: PMC4195536, DOI: 10.1007/s10461-014-0799-7.Peer-Reviewed Original Research
2013
The Next Therapeutic Challenge in HIV: Polypharmacy
Edelman EJ, Gordon KS, Glover J, McNicholl IR, Fiellin DA, Justice AC. The Next Therapeutic Challenge in HIV: Polypharmacy. Drugs & Aging 2013, 30: 613-628. PMID: 23740523, PMCID: PMC3715685, DOI: 10.1007/s40266-013-0093-9.BooksConceptsAntiretroviral therapyHIV infectionSerious adverse drug eventsChronic antiretroviral therapyHarms of polypharmacyLifelong antiretroviral therapyRisk of polypharmacyCombination antiretroviral therapyNumber of medicationsAdverse drug eventsOrgan system injuryDecades of lifePhysiologic frailtyHIV patientsMore medicationsComorbid diseasesGeriatric syndromesImmune dysfunctionMedication adherenceMost HIVTherapeutic challengeChronic inflammationSystem injuryDrug eventsPolypharmacy
2012
Receipt of Opioid Analgesics by HIV-Infected and Uninfected Patients
Edelman EJ, Gordon K, Becker WC, Goulet JL, Skanderson M, Gaither JR, Brennan Braden J, Gordon AJ, Kerns RD, Justice AC, Fiellin DA. Receipt of Opioid Analgesics by HIV-Infected and Uninfected Patients. Journal Of General Internal Medicine 2012, 28: 82-90. PMID: 22895747, PMCID: PMC3539026, DOI: 10.1007/s11606-012-2189-z.Peer-Reviewed Original ResearchConceptsLong-term opioidsHigh-dose opioidsUninfected patientsOpioid receiptHIV statusPain diagnosisHIV infectionVeterans Aging Cohort StudyVeterans Health Administration (VHA) careDaily morphine equivalent doseAcute pain diagnosisDays of opioidsMorphine equivalent doseAging Cohort StudyDesignCross-sectional analysisChronic pain diagnosesICD-9 codesVulnerable patient populationAverage daily doseMorphine equivalentsOpioid prescriptionsCohort studyDaily doseOpioid analgesicsPain managementHIV as an independent risk factor for incident lung cancer
Sigel K, Wisnivesky J, Gordon K, Dubrow R, Justice A, Brown ST, Goulet J, Butt AA, Crystal S, Rimland D, Rodriguez-Barradas M, Gibert C, Park LS, Crothers K. HIV as an independent risk factor for incident lung cancer. AIDS 2012, 26: 1017-1025. PMID: 22382152, PMCID: PMC3580210, DOI: 10.1097/qad.0b013e328352d1ad.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosIndependent risk factorUninfected patientsLung cancerSimilar HIVHIV infectionSurveillance biasRisk factorsIncidence rateVeterans Aging Cohort Study Virtual CohortVeterans Affairs Central Cancer RegistryChronic obstructive pulmonary diseaseIncident lung cancerObstructive pulmonary diseaseCentral Cancer RegistryLung cancer stageSimilar stage distributionRace/ethnicityExcess smokingMultivariable adjustmentAnalytic cohortPulmonary diseaseBacterial pneumoniaCancer RegistryPotential confounders
2007
Delayed Presentation for Human Immunodeficiency Virus (HIV) Care Among Veterans
Gandhi NR, Skanderson M, Gordon KS, Concato J, Justice AC. Delayed Presentation for Human Immunodeficiency Virus (HIV) Care Among Veterans. Medical Care 2007, 45: 1105-1109. PMID: 18049352, PMCID: PMC3460382, DOI: 10.1097/mlr.0b013e3181271476.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusVeterans Health AdministrationHIV presentationHIV careClinical triggersVA healthcareHuman immunodeficiency virus (HIV) careImmune deficiency syndrome diagnosisHIV-positive patientsHalf of patientsRetrospective observational studyCells/Immune deficiency syndromeHalf of veteransVA Medical CenterYear of presentationAntiretroviral therapyCD4 countHIV screeningMedian durationHIV infectionPhysician visitsImmunodeficiency virusDeficiency syndromeObservational study