Role of the NO-cGMP cascade in regulation of L-type Ca2+ currents in isolated cardiomyocytes
Grushin K, Nenov M, Dynnik V, Semushina S, Pakhomova I, Murashev A, Kokoz Y. Role of the NO-cGMP cascade in regulation of L-type Ca2+ currents in isolated cardiomyocytes. Biochemistry (Moscow), Supplement Series A: Membrane And Cell Biology 2008, 2: 243. DOI: 10.1134/s1990747808030082.Peer-Reviewed Original ResearchL-type Ca2NO-cGMP cascadeSodium nitroprussideVoltage-dependent L-type Ca2Basal L-type Ca2Inhibitory effectNO synthase blockerCombination of acetylcholineInhibition of amplitudeRat ventricular myocytesSynthase blockerEffect of arginineEffects of compoundsCyclic nucleotide systemVentricular myocytesBasal currentNitroprussideMM arginineMammalian cardiomyocytesPKG-dependent phosphorylationAcetylcholineExogenous NO sourcesInhibitionCGMP-dependent phosphorylationCa2