2022
Epidemiology, Clinical Characteristics, and Outcomes of Influenza-Associated Hospitalizations in US Children Over 9 Seasons Following the 2009 H1N1 Pandemic
Kamidani S, Garg S, Rolfes MA, Campbell AP, Cummings CN, Haston JC, Openo KP, Fawcett E, Chai SJ, Herlihy R, Yousey-Hindes K, Monroe ML, Kim S, Lynfield R, Smelser C, Muse A, Felsen CB, Billing L, Thomas A, Talbot HK, Schaffner W, Risk I, Anderson EJ. Epidemiology, Clinical Characteristics, and Outcomes of Influenza-Associated Hospitalizations in US Children Over 9 Seasons Following the 2009 H1N1 Pandemic. Clinical Infectious Diseases 2022, 75: 1930-1939. PMID: 35438769, DOI: 10.1093/cid/ciac296.Peer-Reviewed Original ResearchConceptsInfluenza Hospitalization Surveillance NetworkHospital mortality rateMechanical ventilationMortality rateIntensive care unit admissionRecent population-based dataCare unit admissionInfluenza vaccination ratesLaboratory-confirmed influenzaInfluenza-associated hospitalizationsMultivariable logistic regressionPopulation-based dataHospitalization incidence ratesMonths of ageUnit admissionAntiviral treatmentVaccination ratesRisk factorsIncidence rateHigher oddsUS childrenHospitalizationDisease controlLogistic regressionPneumonia
2021
Influenza Antiviral Treatment and Length of Stay
Campbell AP, Tokars JI, Reynolds S, Garg S, Kirley PD, Miller L, Yousey-Hindes K, Anderson EJ, Oni O, Monroe M, Kim S, Lynfield R, Smelser C, Muse AT, Felsen C, Billing LM, Thomas A, Mermel E, Lindegren ML, Schaffner W, Price A, Fry AM. Influenza Antiviral Treatment and Length of Stay. Pediatrics 2021, 148: e2021050417. PMID: 34470815, DOI: 10.1542/peds.2021-050417.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaAntiviral treatmentMedical conditionsHospitalized patientsIllness onsetHigh-risk medical conditionsInfluenza Hospitalization Surveillance NetworkKaplan-Meier survival analysisEarly antiviral treatmentEmpiric antiviral treatmentInfluenza antiviral treatmentLength of stayHospital lengthICU cohortMedian LOSSymptom onsetShorter hospitalizationPrevention recommendationsTime-dependent variablesCox modelAntiviral agentsSurvival analysisCohortDisease controlInfluenzaRates of Influenza-Associated Hospitalization, Intensive Care Unit Admission, and In-Hospital Death by Race and Ethnicity in the United States From 2009 to 2019
O’Halloran A, Holstein R, Cummings C, Kirley P, Alden NB, Yousey-Hindes K, Anderson EJ, Ryan P, Kim S, Lynfield R, McMullen C, Bennett NM, Spina N, Billing LM, Sutton M, Schaffner W, Talbot HK, Price A, Fry AM, Reed C, Garg S. Rates of Influenza-Associated Hospitalization, Intensive Care Unit Admission, and In-Hospital Death by Race and Ethnicity in the United States From 2009 to 2019. JAMA Network Open 2021, 4: e2121880. PMID: 34427679, PMCID: PMC8385599, DOI: 10.1001/jamanetworkopen.2021.21880.Peer-Reviewed Original ResearchConceptsInfluenza-associated hospitalizationsIntensive care unit admissionCare unit admissionCross-sectional studyHospitalization ratesPacific Islander childrenHospital deathICU admissionUnit admissionInfluenza seasonMAIN OUTCOMELaboratory-confirmed influenza-associated hospitalizationsAge groupsAge-adjusted hospitalization ratesHospital death rateICU admission rateIn-Hospital DeathInfluenza-associated diseaseInfluenza-associated outcomesSevere influenza diseaseHispanic childrenPopulation-based surveillanceWhite personsAlaska NativesAge-stratified rates
2019
Effects of Influenza Vaccination in the United States During the 2017–2018 Influenza Season
Rolfes MA, Flannery B, Chung JR, O’Halloran A, Garg S, Belongia EA, Gaglani M, Zimmerman RK, Jackson ML, Monto AS, Alden NB, Anderson E, Bennett NM, Billing L, Eckel S, Kirley PD, Lynfield R, Monroe ML, Spencer M, Spina N, Talbot HK, Thomas A, Torres SM, Yousey-Hindes K, Singleton JA, Patel M, Reed C, Fry AM, McLean H, King J, Nowalk M, Balasubramani G, Bear T, Hickey R, Williams J, Reis E, Moehling K, Eng H, Jackson L, Smith M, Raiyani C, Clipper L, Murthy K, Chen W, Reis M, Petrie J, Malosh R, McSpadden E, Segaloff H, Cheng C, Truscon R, Johnson E, Lamerato L, Rosenblum B, Ford S, Johnson M, Raviotta J, Sax T, Steele J, Susick M, Chabra R, Garofolo E, Iozzi P, Kevish B, Middleton D, Urbanski L, Ponder T, Crumbaker T, Iosefo I, Sleeth P, Gandy V, Bounds K, Kylberg M, Rao A, Fader R, Walker K, Volz M, Ray J, Price D, Thomas J, Wehbe-Janek H, Beeram M, Boyd J, Walkowiak J, Probe R, Couchman G, Motakef S, Arroliga A, Kaniclides A, Bouldin E, Baker C, Berke K, Smith M, Rajesh N, Alleman E, Bauer S, Groesbeck M, Brundidge K, Hafeez N, Jackson J, Anastasia I, Kadoo G, Petnic S, Ryan A, Maslar A, Meek J, Chen R, Stephens S, Thomas S, Segler S, Openo K, Fawcett E, Farley M, Martin A, Ryan P, Sunkel R, Lutich T, Perlmutter R, Grace B, Blood T, Zerrlaut C, McMahon M, Strain A, Christensen J, Angeles K, Butler L, Khanlian S, Mansmann R, McMullen C, Pradhan E, Manzi K, Felsen C, Gaitan M, Long K, Fisher N, Hawley E, O’Shaughnessy R, Scott M, Crawford C, Schaffner W, Markus T, Leib K, Dyer K, Santibanez T, Zhai Y, Lu P, Srivastav A, Hung M. Effects of Influenza Vaccination in the United States During the 2017–2018 Influenza Season. Clinical Infectious Diseases 2019, 69: 1845-1853. PMID: 30715278, PMCID: PMC7188082, DOI: 10.1093/cid/ciz075.Peer-Reviewed Original ResearchConceptsInfluenza-associated illnessVaccine effectivenessInfluenza vaccinationInfluenza seasonMedical visitsCurrent influenza vaccinationInfluenza-associated outcomesInfluenza vaccine coverageInfluenza vaccine effectivenessLaboratory-confirmed influenzaTest-negative designInfluenza virus infectionAge-specific estimatesInfluenza B.Vaccine coverageDisease burdenVirus infectionSubstantial burdenAmbulatory settingVaccinationHospitalizationImproved vaccinesInfluenzaIllnessVisits
2018
Clinical Features and Outcomes of Immunocompromised Children Hospitalized With Laboratory-Confirmed Influenza in the United States, 2011–2015
Collins JP, Campbell AP, Openo K, Farley MM, Cummings CN, Kirley PD, Herlihy R, Yousey-Hindes K, Monroe ML, Ladisky M, Lynfield R, Baumbach J, Spina N, Bennett N, Billing L, Thomas A, Schaffner W, Price A, Garg S, Anderson EJ. Clinical Features and Outcomes of Immunocompromised Children Hospitalized With Laboratory-Confirmed Influenza in the United States, 2011–2015. Journal Of The Pediatric Infectious Diseases Society 2018, 8: 539-549. PMID: 30358877, DOI: 10.1093/jpids/piy101.Peer-Reviewed Original ResearchConceptsSolid organ transplantationImmunocompromised childrenClinical featuresImmunosuppressive therapyIntensive careOrgan transplantationInfluenza Hospitalization Surveillance NetworkHuman immunodeficiency virus/Community-acquired influenzaEarly antiviral treatmentLonger hospitalization durationDuration of hospitalizationIntensive care admissionAntiviral useCare admissionHospital deathHospitalization durationInfluenza vaccinationAntiviral treatmentInfluenza seasonInfluenza severityPrimary outcomeImmunodeficiency syndromeMultivariable analysisImmunoglobulin deficiency
2016
Influenza-Related Hospitalizations and Poverty Levels - United States, 2010-2012.
Hadler JL, Yousey-Hindes K, Pérez A, Anderson EJ, Bargsten M, Bohm SR, Hill M, Hogan B, Laidler M, Lindegren ML, Lung KL, Mermel E, Miller L, Morin C, Parker E, Zansky SM, Chaves SS. Influenza-Related Hospitalizations and Poverty Levels - United States, 2010-2012. MMWR Morbidity And Mortality Weekly Report 2016, 65: 101-5. PMID: 26866729, DOI: 10.15585/mmwr.mm6505a1.Peer-Reviewed Original ResearchConceptsInfluenza related hospitalizationsInfluenza-related diseaseInfluenza-related hospitalizationsAge-adjusted incidenceAnnual influenza vaccineLow-poverty census tractsCensus tractsHigh-poverty census tractsFederal poverty levelInfluenza seasonHospitalization incidenceInfluenza vaccineHospitalization dataSevere diseaseCurrent recommendationsVaccination effortsAntiviral agentsVaccination outreachSocioeconomic status measuresStatus measuresSurveillance sitesSurveillance data analysisTractSES dataIncidence
2014
Impact of requiring influenza vaccination for children in licensed child care or preschool programs--Connecticut, 2012-13 influenza season.
Hadler JL, Yousey-Hindes K, Kudish K, Kennedy ED, Sacco V, Cartter ML. Impact of requiring influenza vaccination for children in licensed child care or preschool programs--Connecticut, 2012-13 influenza season. MMWR Morbidity And Mortality Weekly Report 2014, 63: 181-5. PMID: 24598593, PMCID: PMC4584725.Peer-Reviewed Original ResearchConceptsInfluenza-associated hospitalization ratesEmerging Infections ProgramInfluenza seasonHospitalization ratesVaccination ratesInfluenza transmissionSevere influenza-related illnessInfluenza-related illnessInfluenza-associated hospitalizationsLicensed child care programsOverall population rateGreater percentage decreaseCare admissionInfluenza vaccinationInfluenza vaccineSerious morbiditySusceptible childrenVaccination levelsInfections ProgramVaccination dataCare settingsEIP sitesCare programConnecticut childrenSurveillance sites
2013
Hospital-onset influenza hospitalizations—United States, 2010-2011
Jhung MA, D'Mello T, Pérez A, Aragon D, Bennett NM, Cooper T, Farley MM, Fowler B, Grube SM, Hancock EB, Lynfield R, Morin C, Reingold A, Ryan P, Schaffner W, Sharangpani R, Tengelsen L, Thomas A, Thurston D, Yousey-Hindes K, Zansky S, Finelli L, Chaves SS. Hospital-onset influenza hospitalizations—United States, 2010-2011. American Journal Of Infection Control 2013, 42: 7-11. PMID: 24183534, DOI: 10.1016/j.ajic.2013.06.018.Peer-Reviewed Original ResearchConceptsIntensive care unitChronic medical conditionsCare unitHO casesMedical conditionsLaboratory confirmationInfluenza Hospitalization Surveillance NetworkCommunity-onset casesInfluenza-related hospitalizationsPopulation-based surveillanceInfluenza hospitalizationsHospital admissionInfluenza seasonClinical outcomesMedian lengthInfluenza diagnosisSeasonal influenzaOverall epidemiologyHospitalizationPatientsInfluenzaAdmissionStaySurveillance networkGreater proportionPatients Hospitalized With Laboratory-Confirmed Influenza During the 2010–2011 Influenza Season: Exploring Disease Severity by Virus Type and Subtype
Chaves SS, Aragon D, Bennett N, Cooper T, D'Mello T, Farley M, Fowler B, Hancock E, Kirley PD, Lynfield R, Ryan P, Schaffner W, Sharangpani R, Tengelsen L, Thomas A, Thurston D, Williams J, Yousey-Hindes K, Zansky S, Finelli L. Patients Hospitalized With Laboratory-Confirmed Influenza During the 2010–2011 Influenza Season: Exploring Disease Severity by Virus Type and Subtype. The Journal Of Infectious Diseases 2013, 208: 1305-1314. PMID: 23863950, DOI: 10.1093/infdis/jit316.Peer-Reviewed Original ResearchConceptsVirus type/subtypeAntiviral treatmentTypes/subtypesInfluenza seasonMedical conditionsNeuromuscular disordersOdds of severityPrompt antiviral treatmentChronic lung diseaseChronic metabolic diseaseHospitalized patientsIndependent predictorsMultivariable analysisInfluenza preventionLung diseasePopulation immunityB virusSevere diseaseHealthcare seekingMetabolic diseasesDisease severityVirus typeSurveillance dataVirus strainsPatients
2012
Increase in Rates of Hospitalization Due to Laboratory-Confirmed Influenza Among Children and Adults During the 2009–10 Influenza Pandemic
Cox CM, D'Mello T, Perez A, Reingold A, Gershman K, Yousey-Hindes K, Arnold KE, Farley MM, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett NM, Thomas A, Schaffner W, Finelli L, Network F. Increase in Rates of Hospitalization Due to Laboratory-Confirmed Influenza Among Children and Adults During the 2009–10 Influenza Pandemic. The Journal Of Infectious Diseases 2012, 206: 1350-1358. PMID: 23002448, DOI: 10.1093/infdis/jis517.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaPrevious influenza seasonRate of hospitalizationInfluenza seasonEmerging Infections Program NetworkInfections Program NetworkPopulation-based surveillancePandemic of influenzaAdult age groupsUS Census Bureau dataMean rateH1N1 infectionHospitalization DueHospitalization ratesIncidence rateInfluenza pandemicAge groupsHospitalizationInfluenzaMonthsCensus Bureau dataSurveillanceAdultsEpisodesChildrenReduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic
Garg S, Chaves SS, Pérez A, D'Mello T, Gershman K, Meek J, Yousey-Hindes K, Arnold KE, Farley MM, Tengelsen L, Ryan P, Sharangpani R, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett NM, Fowler B, Bradley K, Thomas A, Cooper T, Schaffner W, Boulton R, Finelli L, Fry AM. Reduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic. Clinical Infectious Diseases 2012, 55: e18-e21. PMID: 22543024, DOI: 10.1093/cid/cis442.Peer-Reviewed Original Research
2011
Neighborhood Socioeconomic Status and Influenza Hospitalizations Among Children: New Haven County, Connecticut, 2003–2010
Yousey-Hindes KM, Hadler JL. Neighborhood Socioeconomic Status and Influenza Hospitalizations Among Children: New Haven County, Connecticut, 2003–2010. American Journal Of Public Health 2011, 101: 1785-1789. PMID: 21778498, PMCID: PMC3154248, DOI: 10.2105/ajph.2011.300224.Peer-Reviewed Original ResearchConceptsInfluenza-associated hospitalizationsPublic Health Disparities Geocoding ProjectNew Haven CountySurveillance dataMean annual incidenceIndividual case characteristicsAge 17 yearsNeighborhood socioeconomic statusInfluenza hospitalizationsInfluenza vaccinationInfluenza seasonAnnual incidenceHospitalization incidenceHospitalizationSocioeconomic status measuresStatus measuresSocioeconomic statusSES dataIncidenceSES measuresOngoing monitoringSES variablesChildrenTractCensus tracts
2009
Peridomestic Lyme Disease Prevention Results of a Population-Based Case–Control Study
Connally NP, Durante AJ, Yousey-Hindes KM, Meek JI, Nelson RS, Heimer R. Peridomestic Lyme Disease Prevention Results of a Population-Based Case–Control Study. American Journal Of Preventive Medicine 2009, 37: 201-206. PMID: 19595558, DOI: 10.1016/j.amepre.2009.04.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnimalsCase-Control StudiesChildChild, PreschoolConnecticutEnvironment DesignEnvironmental ExposureFemaleHumansHygieneInfantLogistic ModelsLyme DiseaseMaleMatched-Pair AnalysisMiddle AgedPopulation SurveillanceProspective StudiesResidence CharacteristicsRisk FactorsSurveys and QuestionnairesTicksYoung AdultConceptsCase-control studyLyme diseaseDisease prevention initiativesConditional logistic regressionDisease prevention measuresErythema migransPotential confoundersRecreational exposureLogistic regressionProspective ageDiseaseCase onsetPrevention resultsPrevention measuresPersonal protectionRiskHoursConfoundersMigransTicksInfectionStudyConnecticut communitiesMonths