2000
Endogenous Adenosine and Secondary Injury after Chest Trauma
Davis K, Fabian T, Ragsdale D, Trenthem L, Proctor A. Endogenous Adenosine and Secondary Injury after Chest Trauma. Journal Of Trauma And Acute Care Surgery 2000, 49: 892-898. PMID: 11086782, DOI: 10.1097/00005373-200011000-00017.Peer-Reviewed Original ResearchConceptsBlunt chest traumaBlunt chest injuryChest traumaAdenosine-regulating agentSecondary injuryBAL proteinChest injuriesEndogenous adenosineLung myeloperoxidase levelsTime of resuscitationAnti-inflammatory actionProgressive inflammatory responseAction of adenosineAlveolar-capillary membraneWet-dry ratioBAL WBCPulmonary contusionContralateral lungMyeloperoxidase levelsSystemic hemodynamicsUninjured lungsLung edemaRight chestMongrel pigsPathophysiologic changes
1999
Prostanoids
Davis K, Fabian T, Croce M, Proctor K. Prostanoids. Journal Of Trauma And Acute Care Surgery 1999, 46: 824-832.. PMID: 10338399, DOI: 10.1097/00005373-199905000-00010.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressurePulmonary capillary leakEnd-expiratory pressurePMN infiltrationPulmonary failureRight thoraxSecondary injuryInflammatory responseCapillary leakPlatelet-derived thromboxaneBlunt chest traumaHours of injurySecondary inflammatory responseBronchoalveolar lavage proteinSerial bronchoalveolar lavagesCyclooxygenase inhibitor indomethacinUnilateral pulmonary contusionPulmonary contusionChest traumaProfound hypoxemiaSham injuryBlunt injuryLeft lungBronchoalveolar lavageNeutrophil content