2023
Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults
Lee M, Smolderen K, Ionescu C, Hillegass W, Romain G, Mena-Hurtado C. Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults. Vascular Medicine 2023, 28: 197-204. PMID: 37293738, DOI: 10.1177/1358863x231151729.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAbnormal ABILower extremity symptomsNormal ABILeg symptomsHigh riskBlack adultsExtremity symptomsStepwise Cox proportional hazards modelKaplan-Meier survival curvesCox proportional hazards modelAnkle-brachial indexFramingham risk factorsJackson Heart StudyProportional hazards modelCardiovascular outcomesCause mortalityArtery diseaseAsymptomatic diseaseAdverse outcomesMean ageSymptom assessmentAsymptomatic participantsRisk factorsSymptomatic participants
2021
Increasing Prevalence of Critical Limb Ischemia Hospitalizations With Distinct Mental Health Burden Among Younger Adults
Harris KM, Mena-Hurtado C, Arham A, Burg MM, Freedland KE, Sinha R, Alabi O, Smolderen KG. Increasing Prevalence of Critical Limb Ischemia Hospitalizations With Distinct Mental Health Burden Among Younger Adults. Journal Of The American College Of Cardiology 2021, 78: 2126-2128. PMID: 34794693, DOI: 10.1016/j.jacc.2021.09.025.Peer-Reviewed Original ResearchPeripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry
Smolderen KG, Lee M, Arora T, Simonov M, Mena-Hurtado C. Peripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry. Current Problems In Cardiology 2021, 47: 101007. PMID: 34627824, PMCID: PMC8496926, DOI: 10.1016/j.cpcardiol.2021.101007.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseSARS-CoV-2Myocardial infarctionMajor adverse cardiovascular eventsAdverse cardiovascular eventsPeripheral artery diseaseOdds of mortalityCOVID-19 infectionCOVID-19 outcomesLogistic regression modelsCardiovascular eventsArtery diseaseArterial diseaseMean ageRisk factorsWorse outcomesPatientsMinority raceMortalityRegistryStrokeDiseaseMACERegression modelsOutcomesTELEHEALTH CARE BEFORE AND DURING COVID-19: TRENDS AND QUALITY IN A LARGE HEALTH SYSTEM
Luna P, Lee M, DeLucia N, London Y, Hoffman P, Burg M, Harris K, Spatz E, Hurtado C, Smolderen K. TELEHEALTH CARE BEFORE AND DURING COVID-19: TRENDS AND QUALITY IN A LARGE HEALTH SYSTEM. Journal Of The American College Of Cardiology 2021, 77: 3229. PMID: 34167649, PMCID: PMC8091376, DOI: 10.1016/s0735-1097(21)04583-6.Peer-Reviewed Original Research
2019
Perceptions of physicians, medical and nursing students concerning shared decision-making: a cross-sectional study
Cantaert GR, Van Hecke A, Smolderen K. Perceptions of physicians, medical and nursing students concerning shared decision-making: a cross-sectional study. Acta Clinica Belgica 2019, 76: 1-9. PMID: 31272338, DOI: 10.1080/17843286.2019.1637487.Peer-Reviewed Original ResearchConceptsPatient-Practitioner Orientation ScaleCross-sectional studyObstetrician/gynecologistsPerceptions of physiciansMultivariate regression analysisSpecific clinical contextIndependent t-testNursing studentsFemale sexGeneral practitionersPhysicians' attitudesGeneral practiceInternal medicineBivariate analysisPhysiciansHealth policyClinical contextNursing traineesSix-point scaleFlemish physiciansSignificant differencesRegression analysisT-testSharing scoreProlonged exposurePsychosocial Factors and Recovery After Acute Myocardial Infarction in Younger Women
Smolderen KG, Brush A, Dreyer RP. Psychosocial Factors and Recovery After Acute Myocardial Infarction in Younger Women. Current Cardiology Reports 2019, 21: 50. PMID: 31020453, DOI: 10.1007/s11886-019-1140-x.Peer-Reviewed Original ResearchConceptsYoung womenAMI outcomesAMI carePsychosocial factorsPsychosocial stressorsAcute myocardial infarction riskAcute myocardial infarctionMyocardial infarction riskPurpose of ReviewToPotential psychosocial factorsAMI riskMyocardial infarctionCare pathwayOutpatient careWorse outcomesAMI incidenceInfarction riskEquitable careMortality ratePsychosocial interventionsCareWomenOutcomesRiskIncidence
2017
Depression Treatment and Health Status Outcomes in Young Patients With Acute Myocardial Infarction
Smolderen KG, Spertus JA, Gosch K, Dreyer RP, D'Onofrio G, Lichtman JH, Geda M, Beltrame J, Safdar B, Bueno H, Krumholz HM. Depression Treatment and Health Status Outcomes in Young Patients With Acute Myocardial Infarction. Circulation 2017, 135: 1762-1764. PMID: 28461419, PMCID: PMC5755692, DOI: 10.1161/circulationaha.116.027042.Peer-Reviewed Original ResearchDepression Treatment and 1-Year Mortality After Acute Myocardial Infarction
Smolderen KG, Buchanan DM, Gosch K, Whooley M, Chan PS, Vaccarino V, Parashar S, Shah AJ, Ho PM, Spertus JA. Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction. Circulation 2017, 135: 1681-1689. PMID: 28209727, PMCID: PMC5796757, DOI: 10.1161/circulationaha.116.025140.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntidepressive AgentsCause of DeathDepressionFemaleHealth StatusHumansKaplan-Meier EstimateMaleMental HealthMiddle AgedMyocardial InfarctionProportional Hazards ModelsProspective StudiesPsychiatric Status Rating ScalesQuality of LifeRegistriesRisk AssessmentRisk FactorsSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionPatient Health Questionnaire-9Untreated depressionMyocardial infarctionObservational multicenter cohort studyMulticenter cohort studyOne-year mortalityLong-term mortalityPrognosis of patientsPHQ-9 scoresTreatment of depressionPHQ-9 criteriaAMI severityPHQ scoresTRIUMPH studyCohort studyClinical factorsDepression treatmentDischarge diagnosisQuestionnaire-9Medical recordsAMI admissionsPatientsBetter outcomesMortality rate
2015
Insurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction
Chen SI, Wang Y, Dreyer R, Strait KM, Spatz ES, Xu X, Smolderen KG, Desai NR, Lorenze NP, Lichtman JH, Spertus JA, D'Onofrio G, Bueno H, Masoudi FA, Krumholz HM. Insurance and Prehospital Delay in Patients ≤55 Years With Acute Myocardial Infarction. The American Journal Of Cardiology 2015, 116: 1827-1832. PMID: 26541907, PMCID: PMC5323057, DOI: 10.1016/j.amjcard.2015.09.018.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrehospital delayInsurance statusMyocardial infarctionSpanish patientsGender differencesHealth care systemUS patientsProspective studyUS cohortUS womenPatientsUniversal insuranceCare systemWomenSignificant gender differencesInfarctionMenInsurance groupsHoursStatusAssociationLarge proportionDifferencesCohortDepressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study
Smolderen KG, Strait KM, Dreyer RP, D'Onofrio G, Zhou S, Lichtman JH, Geda M, Bueno H, Beltrame J, Safdar B, Krumholz HM, Spertus JA. Depressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study. Journal Of The American Heart Association 2015, 4: e001424. PMID: 25836055, PMCID: PMC4579927, DOI: 10.1161/jaha.114.001424.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDepressive symptomsLifetime historyMyocardial infarctionRisk factorsYoung acute myocardial infarctionYoung AMI Patients (VIRGO) studyMore cardiovascular risk factorsYoung womenCardiovascular risk factorsTime of admissionAdverse medical outcomesMore depressive symptomsLow socioeconomic profileAMI severityVIRGO StudyCardiovascular riskChart abstractionYounger patientsClinical profileRelevant sex differencesPatient profilesAMI admissionsMedical outcomesPatientsGender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis
Dreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Bueno H, Krumholz HM, Spertus JA. Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2015, 5: 43-54. PMID: 25681487, PMCID: PMC4658311, DOI: 10.1177/2048872615568967.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrior coronary artery diseaseCoronary artery diseaseHealth statusMyocardial infarctionYounger patientsArtery diseaseCoronary artery disease historyDisease-specific health statusAcute myocardial infarction patientsAggressive symptom controlCornerstone of careWorse physical functionBaseline health statusMedical record abstractionVisual analog scaleHealth status outcomesMyocardial infarction patientsDisease-specific measuresMean health scoresLogistic regression analysisQuality of lifeHealth status informationGender differencesSymptom control
2014
Determinants of invasive treatment in lower extremity peripheral arterial disease
van Zitteren M, Vriens PW, Burger DH, de Fijter WM, Gerritsen GP, Heyligers JM, Nooren MJ, Smolderen KG. Determinants of invasive treatment in lower extremity peripheral arterial disease. Journal Of Vascular Surgery 2014, 59: 400-408.e2. PMID: 24461863, DOI: 10.1016/j.jvs.2013.08.045.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnkle Brachial IndexChi-Square DistributionDecision Support TechniquesEndovascular ProceduresFemaleHealth StatusHumansLower ExtremityMaleMiddle AgedNetherlandsOdds RatioPatient SelectionPeripheral Arterial DiseasePredictive Value of TestsProspective StudiesReferral and ConsultationRisk FactorsTreatment OutcomeUltrasonography, Doppler, DuplexVascular Surgical ProceduresConceptsPeripheral arterial diseaseLower extremity peripheral arterial diseasePhysical component scaleInvasive treatmentLesion locationHealth statusArterial diseaseTreatment referralSymptomatic lower extremity peripheral arterial diseaseProspective observational cohort studyVascular surgery outpatient clinicProximal lesion locationAnkle-brachial indexObservational cohort studySurgery outpatient clinicShort Form-12Poor health statusPatients' health statusPoisson regression analysisPAD diagnosisCohort studyPAD symptomsIndependent predictorsAmbulatory patientsForm-12
2011
Association of Somatic and Cognitive Depressive Symptoms and Biomarkers in Acute Myocardial Infarction: Insights from the Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status Registry
Smolderen KG, Spertus JA, Reid KJ, Buchanan DM, Vaccarino V, Lichtman JH, Bekelman DB, Chan PS. Association of Somatic and Cognitive Depressive Symptoms and Biomarkers in Acute Myocardial Infarction: Insights from the Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status Registry. Biological Psychiatry 2011, 71: 22-29. PMID: 21903199, PMCID: PMC3332544, DOI: 10.1016/j.biopsych.2011.07.029.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAgedBlood PlateletsC-Reactive ProteinCognition DisordersDepressionFemaleHealth Status DisparitiesHumansLeukocyte CountMaleMiddle AgedMyocardial InfarctionNatriuretic Peptide, BrainPeptide FragmentsPrognosisRegistriesRegression AnalysisRetrospective StudiesSurveys and QuestionnairesTranslational Research, BiomedicalYoung AdultConceptsCognitive depressive symptomsSomatic depressive symptomsDepressive symptomsHs-CRPNT-proBNPWBC countAcute Myocardial Infarction Patients' Health Status (TRIUMPH) registryMyocardial infarction prognosisHs-CRP valuesLong-term outcomesAcute myocardial infarctionDepressive symptom domainsAMI prognosisIndex hospitalizationClinical characteristicsCoagulation markersAMI patientsMyocardial infarctionPlatelet levelsBiomarker levelsDepression scoresCertain biomarkersDepression dimensionSymptomsSomatic symptoms
2010
Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms
Smolderen KG, Spertus JA, Vriens PW, Kranendonk S, Nooren M, Denollet J. Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms. Journal Of Vascular Surgery 2010, 52: 637-644. PMID: 20576397, DOI: 10.1016/j.jvs.2010.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAnkle Brachial IndexDepressionFemaleHealth Status DisparitiesHumansIncidenceLogistic ModelsMaleMiddle AgedNetherlandsOdds RatioPeripheral Vascular DiseasesProspective StudiesPsychiatric Status Rating ScalesRegistriesRisk AssessmentRisk FactorsSex FactorsTime FactorsConceptsPeripheral arterial diseaseSignificant depressive symptomsDepressive symptomsGender-age groupsYoung womenArterial diseaseSymptomatic peripheral arterial diseaseEpidemiological Studies Depression ScaleFourfold greater oddsVascular outpatient clinicAnkle-brachial indexPatients' depressive symptomsTime of diagnosisLogistic regression modelsImportant comorbidityPAD diagnosisPAD patientsClinical factorsDepression screeningOutpatient clinicCardiovascular diseaseDepression riskDepression ScaleAdditional adjustmentGreater oddsType D personality mediates the relationship between remembered parenting and perceived health.
van den Broek KC, Smolderen KG, Pedersen SS, Denollet J. Type D personality mediates the relationship between remembered parenting and perceived health. Journal Of The Academy Of Consultation-Liaison Psychiatry 2010, 51: 216-24. PMID: 20484719, DOI: 10.1176/appi.psy.51.3.216.Peer-Reviewed Original ResearchConceptsType D personalityD personalityHealth outcomesShort Form Health SurveyRemembered parentingGeneral Dutch populationBeck Depression InventoryAdverse childhood experiencesAdverse outcomesHospital AnxietyCardiovascular diseaseHealth SurveyDepression ScaleDepression InventoryDutch populationRemembered RelationshipOutcomesChildhood experiencesType DParent scaleAssociationHealthHealth Care Insurance, Financial Concerns in Accessing Care, and Delays to Hospital Presentation in Acute Myocardial Infarction
Smolderen KG, Spertus JA, Nallamothu BK, Krumholz HM, Tang F, Ross JS, Ting HH, Alexander KP, Rathore SS, Chan PS. Health Care Insurance, Financial Concerns in Accessing Care, and Delays to Hospital Presentation in Acute Myocardial Infarction. JAMA 2010, 303: 1392-1400. PMID: 20388895, PMCID: PMC3020978, DOI: 10.1001/jama.2010.409.Peer-Reviewed Original Research
2009
The Association of Cognitive and Somatic Depressive Symptoms With Depression Recognition and Outcomes After Myocardial Infarction
Smolderen KG, Spertus JA, Reid KJ, Buchanan DM, Krumholz HM, Denollet J, Vaccarino V, Chan PS. The Association of Cognitive and Somatic Depressive Symptoms With Depression Recognition and Outcomes After Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2009, 2: 328-337. PMID: 20031858, PMCID: PMC2779543, DOI: 10.1161/circoutcomes.109.868588.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCognitive depressive symptomsSomatic depressive symptomsDepressive symptomsSomatic symptomsAMI patientsMyocardial infarctionCognitive symptomsUnadjusted Cox regression analysisPatient Health Questionnaire scoresDepression recognitionLong-term prognosisCox regression analysisLong-term outcomesRecognition of depressionAssociation of CognitiveCause mortalityCause rehospitalizationIndex hospitalizationMultivariable adjustmentAMI registrySymptom scoresClinical recognitionIndependent associationMedical records
2007
Personality, psychological stress, and self-reported influenza symptomatology
Smolderen K, Vingerhoets A, Croon MA, Denollet J. Personality, psychological stress, and self-reported influenza symptomatology. BMC Public Health 2007, 7: 339. PMID: 18036207, PMCID: PMC2241613, DOI: 10.1186/1471-2458-7-339.Peer-Reviewed Original Research