2023
Association Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association
Smolderen K, Samaan Z, Decker C, Collins T, Lazar R, Itoga N, Mena-Hurtado C, Research O. Association Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circulation 2023, 148: 1511-1528. PMID: 37781785, DOI: 10.1161/cir.0000000000001178.Peer-Reviewed Original ResearchMeSH KeywordsAmerican Heart AssociationComorbidityHumansMental HealthPeripheral Arterial DiseaseRisk FactorsConceptsPsychological interventionsPeripheral artery diseaseMental healthStress reduction interventionsSymptomatic peripheral artery diseaseComorbid mental health conditionsMental health concernsRole of painMental health conditionsMental health burdenPAD careCognitive declineBehavioral health needsArtery diseaseCognitive dysfunctionPsychotropic interventionScientific statementPAD treatmentBehavior changeUse of opioidsAmerican Heart AssociationUse of benzodiazepinesChronic disease managementHealth behaviorsFragmentation of careThe use of evidence-based medical therapy in patients with critical limb-threatening ischaemia.
Bager L, Petersen J, Havers-Borgersen E, Resch T, Smolderen K, Mena-Hurtado C, Eiberg J, Køber L, Fosbøl E. The use of evidence-based medical therapy in patients with critical limb-threatening ischaemia. European Journal Of Preventive Cardiology 2023, 30: 1092-1100. PMID: 36708037, DOI: 10.1093/eurjpc/zwad022.Peer-Reviewed Original ResearchConceptsEvidence-based medical therapyARB/ACEILimb-threatening ischaemiaMyocardial infarctionMedical therapyHistory of MIHigh-risk patientsFirst-time hospitalizationUnadjusted odds ratioYears of ageMore comorbiditiesPatients 40Hazard ratioDanish registriesOverall mortalityAdjusted analysisAdverse prognosisOdds ratioPractice patternsPatientsMortality rateACEIIschaemiaTherapyMortality
2022
The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis
Scierka LE, Mena-Hurtado C, Ahmed ZV, Yousef S, Arham A, Grimshaw AA, Harris KM, Burg M, Vriens PW, Heyligers J, Lee M, Yazgan I, Smolderen KG. The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis. Journal Of Affective Disorders 2022, 320: 169-177. PMID: 36179780, DOI: 10.1016/j.jad.2022.09.098.Peer-Reviewed Original ResearchMeSH KeywordsComorbidityCoronary Artery DiseaseDepressionHumansMalePeripheral Arterial DiseaseRisk FactorsConceptsMajor adverse limb eventsPeripheral artery diseaseAssociation of depressionCause mortalityArtery diseaseDepressive symptomsSystematic reviewAdverse limb eventsAdverse prognostic outcomeCoronary artery diseaseRisk of biasImportant comorbidityPoor outcomeAdverse outcomesPrognostic outcomesPooled resultsRisk factorsObservational studyTreatment statusLimb eventsDepression severityPatientsLarger sample sizeMortalityRisk estimates
2021
Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study
Jelani QU, Mena-Hurtado C, Gosch K, Mohammed M, Labrosciano C, Regan C, Scierka LE, Spertus JA, Nagpal S, Smolderen KG. Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study. PLOS ONE 2021, 16: e0256933. PMID: 34506511, PMCID: PMC8432750, DOI: 10.1371/journal.pone.0256933.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral Artery QuestionnaireSleep apneaHealth statusArtery diseaseSummary scoresDisease-specific Peripheral Artery QuestionnaireFive-year survival curvesHigh ankle-brachial indexPAQ summary scoreVascular specialty clinicsAnkle-brachial indexLog-rank testSleep apnea statusHealth status outcomesWorse health statusQuality of lifeBetter health statusCause mortalityMultivariable adjustmentPAD symptomsCoronary diseasePeripheral interventionsUS patientsMean ageRelation of Cardiovascular Risk Factors to Mortality and Cardiovascular Events in Hospitalized Patients With Coronavirus Disease 2019 (from the Yale COVID-19 Cardiovascular Registry)
Pareek M, Singh A, Vadlamani L, Eder M, Pacor J, Park J, Ghazizadeh Z, Heard A, Cruz-Solbes AS, Nikooie R, Gier C, Ahmed ZV, Freeman JV, Meadows J, Smolderen KGE, Lampert R, Velazquez EJ, Ahmad T, Desai NR. Relation of Cardiovascular Risk Factors to Mortality and Cardiovascular Events in Hospitalized Patients With Coronavirus Disease 2019 (from the Yale COVID-19 Cardiovascular Registry). The American Journal Of Cardiology 2021, 146: 99-106. PMID: 33539857, PMCID: PMC7849530, DOI: 10.1016/j.amjcard.2021.01.029.Peer-Reviewed Original ResearchConceptsCardiovascular risk factorsCoronavirus disease 2019Risk factorsHigher troponin TCardiovascular diseaseCardiovascular eventsHospitalized patientsLaboratory findingsMental statusDisease 2019Multivariable binary logistic regression analysisTroponin TMajor adverse cardiovascular eventsPre-existing cardiovascular diseaseHigher C-reactive proteinCOVID-19 positive patientsPredictors of MACEPrevious ventricular arrhythmiaUse of P2YAdverse cardiovascular eventsProspective cohort studyTertiary care centerC-reactive proteinBinary logistic regression analysisPoor prognostic marker
2020
Impact of Kidney Disease on Peripheral Arterial Interventions: A Systematic Review and Meta-Analysis
Anantha-Narayanan M, Sheikh AB, Nagpal S, Smolderen KG, Turner J, Schneider M, Llanos-Chea F, Mena-Hurtado C. Impact of Kidney Disease on Peripheral Arterial Interventions: A Systematic Review and Meta-Analysis. American Journal Of Nephrology 2020, 51: 527-533. PMID: 32570255, DOI: 10.1159/000508575.Peer-Reviewed Original ResearchConceptsCKD/ESRDCritical limb ischemiaPAD interventionsMajor amputationEarly mortalitySystematic reviewCKD/ESRD patientsPeripheral arterial disease interventionsHigher major amputationOutcomes of patientsPeripheral arterial interventionsSuch comorbid conditionsESRD patientsLimb ischemiaArterial interventionsComorbid conditionsRandomized trialsKidney diseasePatient populationESRDObservational studyRisk populationsFunnel plotPatientsMeta-Analysis
2018
Depression and long-term prognostic outcomes following peripheral endovascular interventions in the VA Healthcare System
Smolderen KG, Plomondon ME, Armstrong EJ, Hess E, Waldo S, Tsai TT, Maddox TM. Depression and long-term prognostic outcomes following peripheral endovascular interventions in the VA Healthcare System. Vascular Medicine 2018, 23: 454-460. PMID: 29801427, DOI: 10.1177/1358863x18770275.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedChi-Square DistributionComorbidityDepressionEndovascular ProceduresFemaleHumansHypertensionKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionPeripheral Arterial DiseaseProportional Hazards ModelsRetrospective StudiesRisk FactorsStrokeTime FactorsTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsNon-fatal cardiovascular eventsPeripheral vascular interventionsCardiovascular eventsDiagnosis of depressionHazard ratioMedical recordsAge-adjusted hazard ratioLong-term prognostic outcomesNon-fatal cardiovascular outcomesPeripheral endovascular interventionsLong-term outcomesPatients' medical recordsVA healthcare systemVeterans Affairs centersCause deathCardiovascular outcomesConsecutive patientsAdditional covariatesEndovascular interventionRecent diagnosisPrognostic outcomesDepressed patientsDisease outcomeVascular interventionsHigh risk
2015
Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis
Dreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Bueno H, Krumholz HM, Spertus JA. Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2015, 5: 43-54. PMID: 25681487, PMCID: PMC4658311, DOI: 10.1177/2048872615568967.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrior coronary artery diseaseCoronary artery diseaseHealth statusMyocardial infarctionYounger patientsArtery diseaseCoronary artery disease historyDisease-specific health statusAcute myocardial infarction patientsAggressive symptom controlCornerstone of careWorse physical functionBaseline health statusMedical record abstractionVisual analog scaleHealth status outcomesMyocardial infarction patientsDisease-specific measuresMean health scoresLogistic regression analysisQuality of lifeHealth status informationGender differencesSymptom control
2014
Peripheral arterial disease, gender, and depression in the Heart and Soul Study
Grenon SM, Cohen BE, Smolderen K, Vittinghoff E, Whooley MA, Hiramoto J. Peripheral arterial disease, gender, and depression in the Heart and Soul Study. Journal Of Vascular Surgery 2014, 60: 396-403. PMID: 24661811, PMCID: PMC4199228, DOI: 10.1016/j.jvs.2014.02.013.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseRisk factorsArterial diseaseDevelopment of PADStable coronary artery diseaseGender-specific risk factorsNontraditional risk factorsProspective cohort studyWorse lipid profileHistory of smokingTraditional risk factorsCoronary artery diseaseStrongest independent factorRole of depressionLogistic regression modelsSoul StudyCohort studyInflammatory biomarkersArtery diseaseDiabetes mellitusElevated fibrinogenSimilar prevalenceLipid profileHigh prevalenceIndependent factors
2011
Accuracy and Prognostic Value of American Heart Association–Recommended Depression Screening in Patients With Coronary Heart Disease
Elderon L, Smolderen KG, Na B, Whooley MA. Accuracy and Prognostic Value of American Heart Association–Recommended Depression Screening in Patients With Coronary Heart Disease. Circulation Cardiovascular Quality And Outcomes 2011, 4: 533-540. PMID: 21862720, DOI: 10.1161/circoutcomes.110.960302.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationComorbidityCoronary DiseaseDepressionDepressive Disorder, MajorDiagnostic Tests, RoutineFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial InfarctionPredictive Value of TestsPrognosisRiskSensitivity and SpecificitySurveys and QuestionnairesSurvival AnalysisUnited StatesConceptsCoronary heart diseaseAmerican Heart AssociationStable coronary heart diseasePatient Health QuestionnaireMajor depressive disorderHeart diseaseCardiovascular eventsPrognostic valueHeart AssociationDepressive disorderHealth QuestionnaireHigh-density lipoprotein levelsDepression screening protocolSubsequent cardiovascular eventsAdverse cardiovascular outcomesBody mass indexGold standard interviewCardiovascular outcomesIdentifies patientsHeart failureScreening methodLipoprotein levelsMass indexDepression screeningMyocardial infarction
2009
Type D Personality and Mortality in Peripheral Arterial Disease: A Pilot Study
Aquarius AE, Smolderen KG, Hamming JF, De Vries J, Vriens PW, Denollet J. Type D Personality and Mortality in Peripheral Arterial Disease: A Pilot Study. JAMA Surgery 2009, 144: 728-733. PMID: 19687376, DOI: 10.1001/archsurg.2009.75.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseType D personalityCause mortalityD personalityIndependent predictorsRenal diseaseArterial diseaseSymptomatic peripheral arterial diseasePilot studyAnkle-brachial indexHigh-risk patientsTraditional risk factorsPatients' medical filesMultivariable logistic regressionRisk of deathVascular surgery departmentType D ScaleClinical predictorsDiabetes mellitusPulmonary diseasePilot followMedical filesSurgery departmentRisk factorsTeaching hospital
2008
Depressive symptoms in peripheral arterial disease: A follow-up study on prevalence, stability, and risk factors
Smolderen KG, Aquarius AE, de Vries J, Smith OR, Hamming JF, Denollet J. Depressive symptoms in peripheral arterial disease: A follow-up study on prevalence, stability, and risk factors. Journal Of Affective Disorders 2008, 110: 27-35. PMID: 18237784, DOI: 10.1016/j.jad.2007.12.238.Peer-Reviewed Original ResearchConceptsAnkle-brachial indexPeripheral arterial diseaseDepressive symptomsPAD patientsArterial diseaseRisk factorsDepressed patientsSymptomatic lower extremity peripheral arterial diseaseLower extremity peripheral arterial diseaseEpidemiological Studies Depression ScaleTreadmill walking distanceCardiovascular risk factorsCoronary artery diseasePsychotropic medication useRelevant depressive symptomsOnly baseline dataPAD severityArtery diseaseMedication usePatient groupPoor prognosisClinical correlatesDepression ScaleClinical careWalking distance