2006
IL-10 regulation of lupus in the NZM2410 murine model
Blenman KR, Duan B, Xu Z, Wan S, Atkinson MA, Flotte TR, Croker BP, Morel L. IL-10 regulation of lupus in the NZM2410 murine model. Laboratory Investigation 2006, 86: 1136-1148. PMID: 16924244, DOI: 10.1038/labinvest.3700468.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearB-Lymphocyte SubsetsCD4-Positive T-LymphocytesDisease Models, AnimalFemaleGene Expression RegulationGene Transfer TechniquesGenetic Predisposition to DiseaseGenetic TherapyInterleukin-10KidneyLupus Erythematosus, SystemicLupus NephritisMiceMice, CongenicMice, Inbred C57BLMice, Inbred NZBReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSpecific Pathogen-Free OrganismsSpleenConceptsIL-10T cell activationMurine modelB cellsElevated IL-10IL-10 levelsSubset of CD4Auto-antibody productionB-cell phenotypeMajor effector armMonths of ageIL-10 regulationMuscle gene deliveryClinical nephritisSLE patientsRegulatory cellsProinflammatory responseSystemic autoimmunityRegulatory cytokinesEffector armSLE susceptibility lociT cellsC57BL/6 backgroundMyeloid cellsCongenic model
2001
The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
Morel L, Blenman K, Croker B, Wakeland E. The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1787-1792. PMID: 11172029, PMCID: PMC29335, DOI: 10.1073/pnas.98.4.1787.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationChromatinGenetic Predisposition to DiseaseLupus Erythematosus, SystemicLupus NephritisMiceMice, Inbred C57BLMultigene FamilyConceptsSusceptibility lociComplex trait lociCluster of genesFine-mapping analysisSystemic lupus erythematosus susceptibility lociTrait lociGenomic intervalsEpistatic interactionsModifier lociChromosomal regionsGenetic complexityAdditional lociLociCongenic analysisSusceptibility genesGenesCongenic intervalChromatinCellular characteristicsCell functionMapping analysisMultiple human studiesRelated functionsAutoimmune phenotypeSle1