2022
Obesity and accelerated epigenetic aging in a high-risk cohort of children
Etzel L, Hastings WJ, Hall MA, Heim CM, Meaney MJ, Noll JG, O’Donnell K, Pokhvisneva I, Rose EJ, Schreier HMC, Shenk CE, Shalev I. Obesity and accelerated epigenetic aging in a high-risk cohort of children. Scientific Reports 2022, 12: 8328. PMID: 35585103, PMCID: PMC9117197, DOI: 10.1038/s41598-022-11562-5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgingChildDNA MethylationEpigenesis, GeneticHumansMiddle AgedObesityProspective StudiesConceptsBody mass indexHigh-risk cohortHigher ageHigher body mass indexOngoing prospective studyBlood cell countChild Health StudyEpigenetic agingHigh-risk childrenPoor health outcomesMiddle-aged adultsMass indexProspective studyFuture morbidityBlood leukocytesMortality riskHealth StudyObesityHealth outcomesCell countCohortEarly lifeContinuous variablesChildrenBiological aging
2018
Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study
Braithwaite EC, Hill J, Pickles A, Glover V, O’Donnell K, Sharp H. Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study. Journal Of Developmental Origins Of Health And Disease 2018, 9: 425-431. PMID: 29631648, PMCID: PMC6075696, DOI: 10.1017/s2040174418000181.Peer-Reviewed Original ResearchConceptsInfant birth weightBirth weightPrenatal cortisolMaternal prenatal cortisolWirral Child HealthFetal growthChild healthAffective disordersDevelopment Study cohortGeneral population estimatesSex-dependent mannerSex-specific mechanismsInverse probability weightsSex-specific effectsCurve cortisolWeeks' gestationGestational ageHospital recordsStudy cohortRisk stratifierFetal programmingGeneral populationGlucocorticoid mechanismsSignificant associationCortisol
2017
Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner
Braithwaite EC, Pickles A, Sharp H, Glover V, O'Donnell KJ, Tibu F, Hill J. Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner. Physiology & Behavior 2017, 175: 31-36. PMID: 28322912, PMCID: PMC5429387, DOI: 10.1016/j.physbeh.2017.03.017.Peer-Reviewed Original ResearchConceptsNeonatal Behavioral Assessment ScaleSex-dependent mannerPrenatal stressMaternal prenatal cortisolPrenatal cortisolFemale infantInfant negative emotionalityFetal developmental trajectoriesMaternal saliva samplesProspective longitudinal cohortDevelopment Study cohortGeneral population estimatesBehavioral Assessment ScaleWirral Child HealthPrenatal cortisol levelsInverse probability weightsStudy cohortMale infantLongitudinal cohortFetal programmingChild healthEvening cortisolSex-specific developmental trajectoriesGlucocorticoid mechanismsPrevention strategies