2018
Maternal antenatal mood and child development: an exploratory study of treatment effects on child outcomes up to 5 years
Milgrom J, Holt CJ, Bleker LS, Holt C, Ross J, Ericksen J, Glover V, O’Donnell K, de Rooij SR, Gemmill AW. Maternal antenatal mood and child development: an exploratory study of treatment effects on child outcomes up to 5 years. Journal Of Developmental Origins Of Health And Disease 2018, 10: 221-231. PMID: 30303063, DOI: 10.1017/s2040174418000739.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyBehavior Rating ScaleChild BehaviorChild DevelopmentChild, PreschoolCognitive Behavioral TherapyDepressionFemaleFollow-Up StudiesHumansIntelligence TestsLongitudinal StudiesMaleMothersParent-Child RelationsPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsRandomized Controlled Trials as TopicSeverity of Illness IndexTreatment OutcomeConceptsChild Behavior ChecklistParenting Stress IndexNeurodevelopmental outcomesChild developmentHigher CBCLIntervention effectsAntenatal depression treatmentMaternal antenatal depressionAdverse neurodevelopmental outcomesInfant neurodevelopmental outcomesAge 2Age 5Cognitive behavioral therapyWPPSI-III scoresNon-significant trendPSI total scoreAntenatal moodAntenatal depressionRoutine careDepression treatmentOriginal cohortTreatment allocationIntervention groupLong-term effectsEffective treatmentDNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome
2016
Stress hormones and posttraumatic stress symptoms following paediatric critical illness: an exploratory study
Als LC, Picouto MD, O’Donnell K, Nadel S, Cooper M, Pierce CM, Kramer T, Glover VAS, Garralda ME. Stress hormones and posttraumatic stress symptoms following paediatric critical illness: an exploratory study. European Child & Adolescent Psychiatry 2016, 26: 511-519. PMID: 27995329, PMCID: PMC5394132, DOI: 10.1007/s00787-016-0933-3.Peer-Reviewed Original ResearchConceptsPediatric critical illnessPosttraumatic stress symptomsCritical illnessHealthy controlsEvening cortisolCortisol concentrationsExploratory case-control studyStress symptomsModest independent predictorCase-control studyEvening cortisol concentrationsBasal cortisol concentrationsPICU admissionPICU groupIndependent predictorsSeptic illnessSymptoms of PTSDSignificant positive associationStudy of childrenPrimary analysisMultivariate analysisSecondary analysisCortisol regulationConsecutive weekdaysStress hormones
2013
Prenatal maternal mood is associated with altered diurnal cortisol in adolescence
O’Donnell K, Glover V, Jenkins J, Browne D, Ben-Shlomo Y, Golding J, O’Connor T. Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. Psychoneuroendocrinology 2013, 38: 1630-1638. PMID: 23433748, PMCID: PMC3695029, DOI: 10.1016/j.psyneuen.2013.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAnxietyCircadian RhythmDepressionFemaleFollow-Up StudiesHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsSalivaSampling StudiesSecretory RateSeverity of Illness IndexSocioeconomic FactorsWakefulnessConceptsPrenatal anxietyDiurnal cortisolMaternal postnatal anxietyMaternal prenatal anxietyPrenatal maternal moodMultilevel model analysisAdolescent cortisolCortisol awakening responsePostnatal covariatesProspective longitudinal studyFlatter diurnal slopeCommunity samplePrenatal moodPostnatal anxietyMaternal moodCortisol samplesMaternal depressionAnxietyAwakening responseLongitudinal studyDiurnal slopePersisting effectPrenatal stressAnimal workALSPAC cohort