2022
To what extent do social support and mastery mediate the association between childhood maltreatment and depression? A sequential causal mediation analysis
Su Y, Li M, D'Arcy C, Caron J, O'Donnell K, Meng X. To what extent do social support and mastery mediate the association between childhood maltreatment and depression? A sequential causal mediation analysis. Epidemiology And Psychiatric Sciences 2022, 31: e77. PMID: 36263598, PMCID: PMC9677445, DOI: 10.1017/s2045796022000609.Peer-Reviewed Original ResearchMeSH KeywordsChildChild AbuseDepressionDepressive Disorder, MajorHumansMediation AnalysisSocial SupportConceptsMajor depressionLongitudinal population-based studySocial supportPopulation-based studyDevelopment of depressionSequential causal mediation analysisMaltreatment subtypesChildhood maltreatment subtypesPsychosocial attributesPotential confoundingSubsequent depressionSubtypesCausal mediation analysisDepressionScientific evidenceChildhood maltreatmentVicious cycleIndependent roleAssociationDirect effectMediation analysisStudied variablesMajor contributorMaltreatment
2021
Epigenetic Age Acceleration and Risk for Posttraumatic Stress Disorder following Exposure to Substantiated Child Maltreatment
Shenk CE, O’Donnell K, Pokhvisneva I, Kobor MS, Meaney MJ, Bensman HE, Allen EK, Olson AE. Epigenetic Age Acceleration and Risk for Posttraumatic Stress Disorder following Exposure to Substantiated Child Maltreatment. Journal Of Clinical Child & Adolescent Psychology 2021, 51: 651-661. PMID: 33471576, PMCID: PMC8289945, DOI: 10.1080/15374416.2020.1864738.Peer-Reviewed Original Research
2018
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome
2015
Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways
Shenk CE, Griffin AM, O'Donnell KJ. Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways. Development And Psychopathology 2015, 27: 1503-1514. PMID: 26535940, PMCID: PMC4774890, DOI: 10.1017/s0954579415000905.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMDD symptomsDepressive disorderRisk pathwaysChild maltreatmentPrevalent psychiatric conditionChild maltreatment populationSubstantiated child maltreatmentPsychiatric conditionsSymptomsClinical interventionsSaliva samplesLaboratory stressorDirect targetingFemale adolescentsCertain childrenChildrenEmotion regulationDisordersComparison conditionSignificant indirect effectCurrent studyMaltreatmentPathwayEmotion dysregulation
2014
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
Anacker C, O'Donnell KJ, Meaney MJ. Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function. Dialogues In Clinical Neuroscience 2014, 16: 321-333. PMID: 25364283, PMCID: PMC4214175, DOI: 10.31887/dcns.2014.16.3/canacker.Peer-Reviewed Original ResearchConceptsExpression of genesParent-offspring interactionsEpigenetic stateEpigenetic mechanismsEpigenetic programmingEpigenetic studiesStress responseGenesNonhuman speciesAdrenal functionExpressionSpeciesEarly life adversityEarly childhood adversityLater riskFuture studiesChildhood adversityLife adversityFunctionSocial adversityAlters