2023
Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions
Apsley A, Etzel L, Hastings W, Heim C, Noll J, O’Donnell K, Schreier H, Shenk C, Ye Q, Shalev I. Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions. Clinical Epigenetics 2023, 15: 33. PMID: 36855187, PMCID: PMC9976543, DOI: 10.1186/s13148-023-01437-5.Peer-Reviewed Original ResearchConceptsComplete blood countImmune cell proportionsAcute psychosocial stressCell proportionPsychosocial stressPsychosocial stress altersImmune cell subtypesAcute laboratory stressorEarly life adversityStress-exposed individualsChild maltreatmentPediatric cohortBlood countCell subtypesAcute stressStress-induced changesPathophysiological statesLife adversityCritical covariatesLaboratory stressorYoung adultsEffects of maltreatmentDNAm alterationsClinical populationsDNA methylation
2019
The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells
McEwen LM, O'Donnell KJ, McGill MG, Edgar RD, Jones MJ, MacIsaac JL, Lin DTS, Ramadori K, Morin A, Gladish N, Garg E, Unternaehrer E, Pokhvisneva I, Karnani N, Kee MZL, Klengel T, Adler NE, Barr RG, Letourneau N, Giesbrecht GF, Reynolds JN, Czamara D, Armstrong JM, Essex MJ, de Weerth C, Beijers R, Tollenaar MS, Bradley B, Jovanovic T, Ressler KJ, Steiner M, Entringer S, Wadhwa PD, Buss C, Bush NR, Binder EB, Boyce WT, Meaney MJ, Horvath S, Kobor MS. The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 117: 23329-23335. PMID: 31611402, PMCID: PMC7519312, DOI: 10.1073/pnas.1820843116.Peer-Reviewed Original ResearchDissecting maternal care: Patterns of maternal parenting in a prospective cohort study
Unternaehrer E, Cost KT, Bouvette‐Turcot A, Gaudreau H, Massicotte R, Dhir SK, Dass S, O'Donnell KJ, Gordon‐Green C, Atkinson L, Levitan RD, Wazana A, Steiner M, Lydon JE, Clark R, Fleming AS, Meaney MJ, Team T. Dissecting maternal care: Patterns of maternal parenting in a prospective cohort study. Journal Of Neuroendocrinology 2019, 31: e12784. PMID: 31442354, DOI: 10.1111/jne.12784.Peer-Reviewed Original ResearchConceptsMaternal parentingParental brainChild outcomesMental healthMaternal parenting styleSelf-report measuresChild-reported symptomsAinsworth Sensitivity ScaleFactor analysisSelf-report questionnairesParenting variablesDifferent latent constructsSupportive parentingRelationship satisfactionAffectionate parentingMotivational componentParenting stylesExploratory factor analysisSchool readinessMultidimensional constructBehavioral problemsParentingBehavioral componentsCooperation taskMother-child bondingA Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment
Toepfer P, O'Donnell KJ, Entringer S, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C. A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 58: 1207-1216. PMID: 30858011, PMCID: PMC6733663, DOI: 10.1016/j.jaac.2019.03.006.Peer-Reviewed Original ResearchAdultAdult Survivors of Child AbuseAllelesDepression, PostpartumFemaleGene-Environment InteractionGenotypeHumansInfantMother-Child RelationsMothersObject AttachmentOxytocinPolymorphism, Single NucleotideQuantitative Trait LociReactive Attachment DisorderReceptors, OxytocinRegression AnalysisStress, PsychologicalYoung Adult
2018
Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study
Braithwaite EC, Hill J, Pickles A, Glover V, O’Donnell K, Sharp H. Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study. Journal Of Developmental Origins Of Health And Disease 2018, 9: 425-431. PMID: 29631648, PMCID: PMC6075696, DOI: 10.1017/s2040174418000181.Peer-Reviewed Original ResearchConceptsInfant birth weightBirth weightPrenatal cortisolMaternal prenatal cortisolWirral Child HealthFetal growthChild healthAffective disordersDevelopment Study cohortGeneral population estimatesSex-dependent mannerSex-specific mechanismsInverse probability weightsSex-specific effectsCurve cortisolWeeks' gestationGestational ageHospital recordsStudy cohortRisk stratifierFetal programmingGeneral populationGlucocorticoid mechanismsSignificant associationCortisolDNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome
2017
Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner
Braithwaite EC, Pickles A, Sharp H, Glover V, O'Donnell KJ, Tibu F, Hill J. Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner. Physiology & Behavior 2017, 175: 31-36. PMID: 28322912, PMCID: PMC5429387, DOI: 10.1016/j.physbeh.2017.03.017.Peer-Reviewed Original ResearchConceptsNeonatal Behavioral Assessment ScaleSex-dependent mannerPrenatal stressMaternal prenatal cortisolPrenatal cortisolFemale infantInfant negative emotionalityFetal developmental trajectoriesMaternal saliva samplesProspective longitudinal cohortDevelopment Study cohortGeneral population estimatesBehavioral Assessment ScaleWirral Child HealthPrenatal cortisol levelsInverse probability weightsStudy cohortMale infantLongitudinal cohortFetal programmingChild healthEvening cortisolSex-specific developmental trajectoriesGlucocorticoid mechanismsPrevention strategies
2015
Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways
Shenk CE, Griffin AM, O'Donnell KJ. Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways. Development And Psychopathology 2015, 27: 1503-1514. PMID: 26535940, PMCID: PMC4774890, DOI: 10.1017/s0954579415000905.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMDD symptomsDepressive disorderRisk pathwaysChild maltreatmentPrevalent psychiatric conditionChild maltreatment populationSubstantiated child maltreatmentPsychiatric conditionsSymptomsClinical interventionsSaliva samplesLaboratory stressorDirect targetingFemale adolescentsCertain childrenChildrenEmotion regulationDisordersComparison conditionSignificant indirect effectCurrent studyMaltreatmentPathwayEmotion dysregulation
2010
Anxiety, depression and saliva cortisol in women with a medical disorder during pregnancy
King NM, Chambers J, O’Donnell K, Jayaweera SR, Williamson C, Glover VA. Anxiety, depression and saliva cortisol in women with a medical disorder during pregnancy. Archives Of Women's Mental Health 2010, 13: 339-345. PMID: 20101421, DOI: 10.1007/s00737-009-0139-5.Peer-Reviewed Original ResearchConceptsMedical disordersSaliva cortisolDiurnal saliva samplesAdverse pregnancy outcomesHigher EPDS scoresSubgroup of womenExtra psychological supportSelf-rating questionnaireVs. 35.2Antenatal womenHyperemesis gravidarumPregnancy outcomesEPDS scoresPregnant womenVs. 5.9Neurodevelopmental problemsCortisol levelsHealth professionalsPregnancySaliva samplesDisorder groupElevated levelsPsychological supportWomenDisorders