2024
Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment
Tchalova K, Lydon J, Atkinson L, Fleming A, Kennedy J, Lecompte V, Meaney M, Moss E, O’Donnell K, O’Donnell K, Silveira P, Sokolowski M, Steiner M, Bartz J. Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment. Translational Psychiatry 2024, 14: 181. PMID: 38580654, PMCID: PMC10997775, DOI: 10.1038/s41398-024-02888-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultCanadaCohort StudiesFemaleGenotypeHumansMother-Child RelationsPolymorphism, GeneticPolymorphism, Single NucleotideReceptors, Opioid, muConceptsMaternal sensitivityChild attachmentAttachment behaviorExpression of attachment behaviorLevels of maternal sensitivityOPRM1 A118G genotypeInfluence of maternal sensitivityNon-human animal researchAmbivalent attachment patternsStrange Situation paradigmMu-opioid receptor geneOPRM1 A118G polymorphismA118G genotypeChildren's attachment stylesMother-child interactionA118G polymorphismEndogenous opioid systemMinor G alleleSensitive maternal careMother-infant attachmentInfant rhesus macaquesG alleleC77G polymorphismReceptor geneSituation paradigm
2022
Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach
Meng X, Wang M, O’Donnell K, Caron J, Meaney MJ, Li Y. Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach. Translational Psychiatry 2022, 12: 240. PMID: 35676267, PMCID: PMC9177831, DOI: 10.1038/s41398-022-02015-8.Peer-Reviewed Original ResearchMeSH KeywordsCanadaDepressive Disorder, MajorGenetic Predisposition to DiseaseHumansPhenotypePolymorphism, Single NucleotideConceptsMajor depressive disorderRisk of MDDDepressive disorderMDD subtypesMDD diagnosisRisk categorizationMajor public health problemLongitudinal community-based cohortCommunity-based cohortRisk prediction toolsGenetic variantsPublic health problemPrevalent mental disordersRisk prediction modelMDD cohortMDD patientsGenetic predispositionHealth problemsEarly identificationMental disordersMDD casesPotential genetic variantsDisordersCohortSubtypes
2021
DCC gene network in the prefrontal cortex is associated with total brain volume in childhood
Morgunova A, Pokhvisneva I, Nolvi S, Entringer S, Wadhwa P, Gilmore J, Styner M, Buss C, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP, Flores CA. DCC gene network in the prefrontal cortex is associated with total brain volume in childhood. Journal Of Psychiatry And Neuroscience 2021, 46: e154-e163. PMID: 33206040, PMCID: PMC7955849, DOI: 10.1503/jpn.200081.Peer-Reviewed Original ResearchConceptsTotal brain volumeExpression-based polygenic risk scoreBrain volumePrefrontal cortexSingle nucleotide polymorphismsHigher total brain volumeCommunity-based cohortChildren 1.5Polygenic risk scoresMaternal adversityRisk scoreIndependent cohortReplication cohortCohortCortexBrain developmentChildren 8Donor databaseSmall sample sizeEffect sizeReplication analysis
2019
Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in Children
Miguel PM, Pereira LO, Barth B, de Mendonça Filho EJ, Pokhvisneva I, Nguyen TTT, Garg E, Razzolini BR, Koh DXP, Gallant H, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP. Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in Children. Biological Psychiatry 2019, 86: 621-630. PMID: 31142432, DOI: 10.1016/j.biopsych.2019.03.983.Peer-Reviewed Original ResearchConceptsExpression-based polygenic risk scoreGray matter densityBrain gray matter densityPrefrontal cortexHypoxic-ischemic conditionsHistory of exposurePrefrontal cortex expressionExecutive functionIdentification of childrenHypoxia-ischemiaPerinatal complicationsHealthy childrenRisk factorsPolygenic risk scoresHigh riskRisk scoreDopamine reuptakeBirth cohortCortex expressionPoor oxygenationImpaired executive functionBrain developmentGenetic polymorphismsA biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions
Dass S, McCracken K, Pokhvisneva I, Chen LM, Garg E, Nguyen TTT, Wang Z, Barth B, Yaqubi M, McEwen LM, MacIsaac JL, Diorio J, Kobor MS, O'Donnell KJ, Meaney MJ, Silveira PP. A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions. EBioMedicine 2019, 42: 188-202. PMID: 30922963, PMCID: PMC6491717, DOI: 10.1016/j.ebiom.2019.03.051.Peer-Reviewed Original ResearchMeSH KeywordsBrainEndophenotypesFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHippocampusHumansMalePhenotypePolymorphism, Single NucleotideReceptor, InsulinReproducibility of ResultsConceptsCognitive performancePolygenic scoresRelated mental disordersChild impulsivityIndividual differencesSpecific brain regionsInhibitory controlNeurobiological mechanismsCommunity sampleBrain regionsConventional GWASMesocorticolimbic systemImpulsivityMental disordersPsychopathologyAddictionNeural functionEndophenotypesAlzheimer's diseaseScoresADHDDisordersMemoryFunctioningGenetic scoreA Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment
Toepfer P, O'Donnell KJ, Entringer S, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C. A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 58: 1207-1216. PMID: 30858011, PMCID: PMC6733663, DOI: 10.1016/j.jaac.2019.03.006.Peer-Reviewed Original ResearchAdultAdult Survivors of Child AbuseAllelesDepression, PostpartumFemaleGene-Environment InteractionGenotypeHumansInfantMother-Child RelationsMothersObject AttachmentOxytocinPolymorphism, Single NucleotideQuantitative Trait LociReactive Attachment DisorderReceptors, OxytocinRegression AnalysisStress, PsychologicalYoung Adult
2018
PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores
Chen LM, Yao N, Garg E, Zhu Y, Nguyen TTT, Pokhvisneva I, Hari Dass SA, Unternaehrer E, Gaudreau H, Forest M, McEwen LM, MacIsaac JL, Kobor MS, Greenwood CMT, Silveira PP, Meaney MJ, O’Donnell K. PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores. BMC Bioinformatics 2018, 19: 295. PMID: 30089455, PMCID: PMC6083617, DOI: 10.1186/s12859-018-2289-9.Peer-Reviewed Original Research
2017
Maternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHD
O'Donnell KJ, Glover V, Lahti J, Lahti M, Edgar RD, Räikkönen K, O'Connor TG. Maternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHD. PLOS ONE 2017, 12: e0177506. PMID: 28614354, PMCID: PMC5470664, DOI: 10.1371/journal.pone.0177506.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAttention Deficit Disorder with HyperactivityCatechol O-MethyltransferaseChildFemaleGene-Environment InteractionGenotypeHumansLongitudinal StudiesMaleMemory, Short-TermMothersPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsProspective StudiesSelf ReportConceptsMaternal prenatal anxietySymptoms of ADHDPrenatal anxietyChildren's symptomsSelf-report measuresInter-individual differencesRs4680 genotypeIndividual differencesHyperactivity symptomsChildren's responsesADHDDevelopmental outcomesCOMT genotypeAnxietyAge 8 yearsMemoryVal/Val genotypeVal/ALSPAC cohortChild neurodevelopmentYears of ageFunctional genetic variationVal genotypeCOMTGene-environment interactionsEffects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk
Qiu A, Shen M, Buss C, Chong YS, Kwek K, Saw SM, Gluckman PD, Wadhwa PD, Entringer S, Styner M, Karnani N, Heim CM, O'Donnell KJ, Holbrook JD, Fortier MV, Meaney MJ, . Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk. Cerebral Cortex 2017, 27: 1-13. PMID: 28334351, PMCID: PMC6057508, DOI: 10.1093/cercor/bhx065.Peer-Reviewed Original ResearchMeSH KeywordsAsian PeopleBrainBrain MappingCohort StudiesComputational BiologyDepressive Disorder, MajorFemaleFetal DevelopmentGene Regulatory NetworksGenotypeGestational AgeHumansImage Processing, Computer-AssistedInfant, NewbornMagnetic Resonance ImagingMaleMaternal-Fetal RelationsPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsSocial ClassConceptsMaternal depressive symptomsDepressive symptomsHippocampal volumeRight amygdalaRight hippocampal volumeGlutamate receptor activityNeonatal brain developmentMajor depressive disorderRight amygdala volumeMother-infant dyadsFetal neurodevelopmentAmericas cohortAsian cohortDepressive disorderNeurotrophic signalingRight hippocampusCognitive-emotional functionRisk scoreAmygdala volumeSignificant interactionFetal developmentVentromedial prefrontal cortexSocio-economic statusBrain regionsReceptor activity