To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort.
Li M, O'Donnell K, Caron J, Meaney M, Kobor M, D'Arcy C, Su Y, Liu A, Meng X. To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort. Development And Psychopathology 2022, 36: 50-61. PMID: 36102218, DOI: 10.1017/s0954579422000918.Peer-Reviewed Original ResearchMajor depressive disorderLongitudinal community-based cohortCommunity-based cohortDepressive disorderChildhood maltreatmentRisk of MDDSocial supportSubsequent major depressive disorderGenetic predispositionDirect effectPrevention programsSociodemographic characteristicsNegative copingNegative coping strategiesCoping strategiesPositive coping strategiesCohortDisordersPotential factorsPositive copingMediation analysisRobust evidenceDetrimental effectsCopingMaltreatmentIntegrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach
Meng X, Wang M, O’Donnell K, Caron J, Meaney MJ, Li Y. Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach. Translational Psychiatry 2022, 12: 240. PMID: 35676267, PMCID: PMC9177831, DOI: 10.1038/s41398-022-02015-8.Peer-Reviewed Original ResearchConceptsMajor depressive disorderRisk of MDDDepressive disorderMDD subtypesMDD diagnosisRisk categorizationMajor public health problemLongitudinal community-based cohortCommunity-based cohortRisk prediction toolsGenetic variantsPublic health problemPrevalent mental disordersRisk prediction modelMDD cohortMDD patientsGenetic predispositionHealth problemsEarly identificationMental disordersMDD casesPotential genetic variantsDisordersCohortSubtypes