Early intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial
Milgrom J, Hirshler Y, Holt C, Skouteris H, Galbally M, East C, Glover V, Reece J, O’Donnell K, Walker S, Malloy S, Gemmill A. Early intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial. BMC Psychology 2023, 11: 222. PMID: 37542332, PMCID: PMC10401817, DOI: 10.1186/s40359-023-01244-w.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyChild Behavior ChecklistChild outcomesBehavioral developmentMaternal depressionAntenatal depression treatmentChild developmental outcomesRevised Infant Behavior QuestionnaireInfant Behavior QuestionnaireActive psychological treatmentsMother-infant interactionAntenatal depressionAdditional secondary outcome measuresMonths of ageAdverse child outcomesOutcome measuresPsychological treatmentCBT programMental health disordersBehavioral therapyAnxiety symptomsBehavior ChecklistBehavioral problemsExternalising problemsInternalising scalesMaternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?
Creasey N, Beijers R, O'Donnell K, de Weerth C, Tollenaar M. Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Development And Psychopathology 2023, 36: 967-978. PMID: 36896668, DOI: 10.1017/s0954579423000226.Peer-Reviewed Original ResearchAge 5 weeksChild mental healthMaternal sensitivityMental healthGlucocorticoid receptor gene methylationAge 6 yearsChildren's internalizingMethylation levelsMother-infant interactionDNA methylation levelsAnimal modelsEarly infancyStress regulatory systemsExternalizing behaviorsEarly caregiving environmentGene DNA methylationAge 6Longitudinal studyLower DNA methylation levelsResponsive caregivingSame childrenCommunity sampleCaregiving environmentGene methylationDNA methylation