2024
Differential interactions between gene expressions and stressors across the lifespan in major depressive disorder
Wang R, Su Y, O'Donnell K, Caron J, Meaney M, Meng X, Li Y. Differential interactions between gene expressions and stressors across the lifespan in major depressive disorder. Journal Of Affective Disorders 2024, 362: 688-697. PMID: 39029669, DOI: 10.1016/j.jad.2024.07.069.Peer-Reviewed Original ResearchMDD riskDepressive disorderPatterns of stressorsVulnerability-stress theoriesSusceptibility to MDDTranscriptome-wide association studyDimensions of stressorsLatent profile modelsLongitudinal community-based cohortPrefrontal cortexLifetime stressorsMDDGene expressionBrain amygdalaBasal gangliaStress researchNominal p-values <Southwest MontrealStressorsBrainFine-mapping analysisBrain cortexStudy cohortGenetic predispositionCortex
2022
Specific and cumulative lifetime stressors in the aetiology of major depression: A longitudinal community-based population study
Su Y, D'Arcy C, Li M, O'Donnell K, Caron J, Meaney M, Meng X. Specific and cumulative lifetime stressors in the aetiology of major depression: A longitudinal community-based population study. Epidemiology And Psychiatric Sciences 2022, 31: e3. PMID: 35078547, PMCID: PMC8851045, DOI: 10.1017/s2045796021000779.Peer-Reviewed Original ResearchConceptsGenetic predispositionSubsequent depressionStressful life eventsLifetime stressorsLongitudinal community-based cohort studyPsychosocial stressorsCommunity-based cohort studyCommunity-based population studyStressful eventsMental illness preventionMultivariate logistic regressionHealth-related factorsDevelopment of depressionChildhood maltreatmentMental health promotionEtiology of depressionPresent studyStressful experiencesLife eventsChild-parent bondingCumulative stressful experiencesSouthwest of MontrealPolygenetic risk scoresCohort studySocio-demographic characteristics