2023
A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
Arcego D, Buschdorf J, O'Toole N, Wang Z, Barth B, Pokhvisneva I, Rayan N, Patel S, de Mendonça Filho E, Lee P, Tan J, Koh M, Sim C, Parent C, de Lima R, Clappison A, O'Donnell K, Dalmaz C, Arloth J, Provençal N, Binder E, Diorio J, Silveira P, Meaney M. A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. Biological Psychiatry 2023, 95: 48-61. PMID: 37406925, DOI: 10.1016/j.biopsych.2023.06.028.Peer-Reviewed Original ResearchConceptsHippocampal dentate gyrusDentate gyrusPsychiatric disordersHuman hippocampal cellsBrain gray matter densityEarly adversitySingle nucleotide polymorphismsMultiple psychiatric conditionsEarly life adversityGray matter densityAdult female macaquesMental health outcomesTranscriptional activityGlucocorticoid exposureNucleotide polymorphismsLater psychosisStress mediatorsHippocampal cellsPsychotic disordersAnimal modelsHealth outcomesPsychiatric conditionsSignificant associationFemale macaquesMental health
2022
Cumulative risk exposure and child cellular aging in a Dutch low‐risk community sample
Beijers R, Thije I, Bolhuis E, O'Donnell K, Tollenaar M, Shalev I, Hastings W, MacIsaac J, Lin D, Meaney M, Kobor M, Belsky J, de Weerth C. Cumulative risk exposure and child cellular aging in a Dutch low‐risk community sample. Psychophysiology 2022, 60: e14205. PMID: 36323627, DOI: 10.1111/psyp.14205.Peer-Reviewed Original ResearchConceptsChildhood risk exposuresLow-risk community sampleAge 6Cortisol reactivityAge 10Cumulative risk exposureCommunity sampleCellular agingPhysical health outcomesHealth outcomesStressor exposureTelomere lengthSecondary findingsLater lifeChild cortisol reactivityRegression analysisSignificant main effectFurther investigationExposurePositive correlationMore researchStrong conclusionsAgingBiomarkersObesity and accelerated epigenetic aging in a high-risk cohort of children
Etzel L, Hastings WJ, Hall MA, Heim CM, Meaney MJ, Noll JG, O’Donnell K, Pokhvisneva I, Rose EJ, Schreier HMC, Shenk CE, Shalev I. Obesity and accelerated epigenetic aging in a high-risk cohort of children. Scientific Reports 2022, 12: 8328. PMID: 35585103, PMCID: PMC9117197, DOI: 10.1038/s41598-022-11562-5.Peer-Reviewed Original ResearchConceptsBody mass indexHigh-risk cohortHigher ageHigher body mass indexOngoing prospective studyBlood cell countChild Health StudyEpigenetic agingHigh-risk childrenPoor health outcomesMiddle-aged adultsMass indexProspective studyFuture morbidityBlood leukocytesMortality riskHealth StudyObesityHealth outcomesCell countCohortEarly lifeContinuous variablesChildrenBiological aging
2016
Chapter 7 Maternal Prenatal Stress and the Developmental Origins of Mental Health The Role of Epigenetics
O’Donnell K, Glover V. Chapter 7 Maternal Prenatal Stress and the Developmental Origins of Mental Health The Role of Epigenetics. 2016, 103-126. DOI: 10.1016/b978-0-12-801383-0.00007-4.Chapters
2014
Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age
O'Donnell KJ, Glover V, Holbrook JD, O'Connor TG. Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age. Development And Psychopathology 2014, 26: 1255-1266. PMID: 25422959, DOI: 10.1017/s095457941400100x.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) genePrenatal maternal anxietyYears of agePrenatal anxietyBDNF polymorphismMaternal anxietyBrain-derived neurotrophic factor (BDNF) genotypeNeurotrophic factor genotypeInternalizing symptomsNeurotrophic factor geneAge 15 yearsAvon Longitudinal StudyMaternal prenatal anxietyMaternal symptomsChild internalizing symptomsGene-environment interactionsClinical InterviewPopulation cohortHealth outcomesSymptomsDiagnostic assessmentPsychosocial risksDifficulties QuestionnaireAge 13Longitudinal study