2023
A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
Arcego D, Buschdorf J, O'Toole N, Wang Z, Barth B, Pokhvisneva I, Rayan N, Patel S, de Mendonça Filho E, Lee P, Tan J, Koh M, Sim C, Parent C, de Lima R, Clappison A, O'Donnell K, Dalmaz C, Arloth J, Provençal N, Binder E, Diorio J, Silveira P, Meaney M. A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. Biological Psychiatry 2023, 95: 48-61. PMID: 37406925, DOI: 10.1016/j.biopsych.2023.06.028.Peer-Reviewed Original ResearchConceptsHippocampal dentate gyrusDentate gyrusPsychiatric disordersHuman hippocampal cellsBrain gray matter densityEarly adversitySingle nucleotide polymorphismsMultiple psychiatric conditionsEarly life adversityGray matter densityAdult female macaquesMental health outcomesTranscriptional activityGlucocorticoid exposureNucleotide polymorphismsLater psychosisStress mediatorsHippocampal cellsPsychotic disordersAnimal modelsHealth outcomesPsychiatric conditionsSignificant associationFemale macaquesMental health
2020
Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes
de Lima RMS, Barth B, Arcego DM, de Mendonça Filho EJ, Clappison A, Patel S, Wang Z, Pokhvisneva I, Sassi RB, Hall GBC, Kobor MS, O'Donnell KJ, de Vasconcellos Bittencourt A, Meaney MJ, Dalmaz C, Silveira PP. Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes. Frontiers In Neuroscience 2020, 14: 198. PMID: 32256307, PMCID: PMC7093057, DOI: 10.3389/fnins.2020.00198.Peer-Reviewed Original Research
2019
Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in Children
Miguel PM, Pereira LO, Barth B, de Mendonça Filho EJ, Pokhvisneva I, Nguyen TTT, Garg E, Razzolini BR, Koh DXP, Gallant H, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP. Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in Children. Biological Psychiatry 2019, 86: 621-630. PMID: 31142432, DOI: 10.1016/j.biopsych.2019.03.983.Peer-Reviewed Original ResearchConceptsExpression-based polygenic risk scoreGray matter densityBrain gray matter densityPrefrontal cortexHypoxic-ischemic conditionsHistory of exposurePrefrontal cortex expressionExecutive functionIdentification of childrenHypoxia-ischemiaPerinatal complicationsHealthy childrenRisk factorsPolygenic risk scoresHigh riskRisk scoreDopamine reuptakeBirth cohortCortex expressionPoor oxygenationImpaired executive functionBrain developmentGenetic polymorphisms