2023
Associations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples
Perret L, Geoffroy M, Barr E, Parnet F, Provencal N, Boivin M, O'Donnell K, Suderman M, Power C, Turecki G, Ouellet-Morin I. Associations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples. Frontiers In Cell And Developmental Biology 2023, 10: 1051556. PMID: 36712964, PMCID: PMC9879289, DOI: 10.3389/fcell.2022.1051556.Peer-Reviewed Original ResearchDepressive symptomsSuicidal ideationEpigenome-wide DNA methylationHigh riskHigher depressive symptom scoresSelf-reported depressive symptomsDepressive symptom scoresTwo-cohort studyEpigenetic agingPopulation-based sampleEpigenetic indexBritish birth cohortChildhood peer victimizationQuebec Longitudinal StudySymptom scoresCohort 1Birth cohortSymptomsDNA methylation markersCohortPace of agingCandidate gene studiesLongitudinal studyIdeationMethylation markers
2022
Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study
Felt JM, Harrington KD, Ram N, O'Donnell KJ, Sliwinski MJ, Benson L, Zhang Z, Meaney MJ, Putnam FW, Noll JG, Shenk CE. Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study. The Journals Of Gerontology Series B 2022, 78: 585-595. PMID: 36190812, PMCID: PMC10066744, DOI: 10.1093/geronb/gbac158.Peer-Reviewed Original ResearchConceptsReceptive language abilityChild sexual abuseEarly life adversityLanguage abilityCognitive agingLife adversityPeabody Picture VocabularyPPVT-R scoresReceptive languageCognitive functioningPicture VocabularyComparison conditionNormative trajectoriesSexual abuseInterindividual differencesIndependent measuresMidlifeAdversityEpigenetic age accelerationDevelopment studiesQuadratic trendQuadratic growth modelAge accelerationEpigenetic agingAbilityObesity and accelerated epigenetic aging in a high-risk cohort of children
Etzel L, Hastings WJ, Hall MA, Heim CM, Meaney MJ, Noll JG, O’Donnell K, Pokhvisneva I, Rose EJ, Schreier HMC, Shenk CE, Shalev I. Obesity and accelerated epigenetic aging in a high-risk cohort of children. Scientific Reports 2022, 12: 8328. PMID: 35585103, PMCID: PMC9117197, DOI: 10.1038/s41598-022-11562-5.Peer-Reviewed Original ResearchConceptsBody mass indexHigh-risk cohortHigher ageHigher body mass indexOngoing prospective studyBlood cell countChild Health StudyEpigenetic agingHigh-risk childrenPoor health outcomesMiddle-aged adultsMass indexProspective studyFuture morbidityBlood leukocytesMortality riskHealth StudyObesityHealth outcomesCell countCohortEarly lifeContinuous variablesChildrenBiological aging
2021
Internalizing symptoms associate with the pace of epigenetic aging in childhood
Tollenaar MS, Beijers R, Garg E, Nguyen TTT, Lin DTS, MacIsaac JL, Shalev I, Kobor MS, Meaney MJ, O'Donnell KJ, de Weerth C. Internalizing symptoms associate with the pace of epigenetic aging in childhood. Biological Psychology 2021, 159: 108021. PMID: 33460784, DOI: 10.1016/j.biopsycho.2021.108021.Peer-Reviewed Original ResearchConceptsAdvanced biological agingChildhood psychiatric symptomsAge 6Longitudinal cohort studyInternalizing symptomsBiological agingChild mental healthCohort studyBuccal epithelial cellsPsychiatric symptomsSymptomsMental healthEpithelial cellsInternalizing disordersStatistical significanceAge 2.5Highest EAAExternalizing symptomsChildhoodEpigenetic agingHorvath clockGenome-wide DNA methylationEAA