2023
Perinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents
Kee M, Cremaschi A, De Iorio M, Chen H, Montreuil T, Nguyen T, Côté S, O’Donnell K, Giesbrecht G, Letourneau N, Chan S, Meaney M. Perinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents. JAMA Network Open 2023, 6: e2339942. PMID: 37883082, PMCID: PMC10603499, DOI: 10.1001/jamanetworkopen.2023.39942.Peer-Reviewed Original ResearchConceptsSelf-reported depressive symptomsMaternal depressive symptomsDepressive symptomsPerinatal periodPostnatal periodEdinburgh Postnatal Depression ScalePostnatal Depression ScaleEpidemiological Studies DepressionHealth policy guidelinesPublic health initiativesGroups of mothersCohort studyObservational cohortProspective cohortPregnancy influencesReferral guidelinesMultiple time pointsDepression ScaleMAIN OUTCOMEPregnancyPostnatal onsetStudies DepressionHealth initiativesTimely interventionCohortAssociations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples
Perret L, Geoffroy M, Barr E, Parnet F, Provencal N, Boivin M, O'Donnell K, Suderman M, Power C, Turecki G, Ouellet-Morin I. Associations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples. Frontiers In Cell And Developmental Biology 2023, 10: 1051556. PMID: 36712964, PMCID: PMC9879289, DOI: 10.3389/fcell.2022.1051556.Peer-Reviewed Original ResearchDepressive symptomsSuicidal ideationEpigenome-wide DNA methylationHigh riskHigher depressive symptom scoresSelf-reported depressive symptomsDepressive symptom scoresTwo-cohort studyEpigenetic agingPopulation-based sampleEpigenetic indexBritish birth cohortChildhood peer victimizationQuebec Longitudinal StudySymptom scoresCohort 1Birth cohortSymptomsDNA methylation markersCohortPace of agingCandidate gene studiesLongitudinal studyIdeationMethylation markers
2022
Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development
Perret LC, Boivin M, Morneau‐Vaillancourt G, Andlauer TFM, Paquin S, Langevin S, Girard A, Turecki G, O'Donnell K, Tremblay RE, Côté SM, Gouin J, Ouellet‐Morin I, Geoffroy M. Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development. Journal Of Child Psychology And Psychiatry 2022, 64: 388-396. PMID: 36124742, DOI: 10.1111/jcpp.13706.Peer-Reviewed Original ResearchConceptsDepressive symptomsGenetic predispositionQuebec Longitudinal StudyPolygenic risk scoresRisk scoreSelf-reported depressive symptomsLongitudinal studyIndividual genetic predispositionSuch gene-environment interactionsGene-environment interactionsSuch symptomsSymptomsDepressionChild developmentPredispositionAdolescencePeer victimisationFuture studiesEarly adolescenceScoresRiskAdolescentsAssociation
2017
Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk
Qiu A, Shen M, Buss C, Chong YS, Kwek K, Saw SM, Gluckman PD, Wadhwa PD, Entringer S, Styner M, Karnani N, Heim CM, O'Donnell KJ, Holbrook JD, Fortier MV, Meaney MJ, . Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk. Cerebral Cortex 2017, 27: 1-13. PMID: 28334351, PMCID: PMC6057508, DOI: 10.1093/cercor/bhx065.Peer-Reviewed Original ResearchMeSH KeywordsAsian PeopleBrainBrain MappingCohort StudiesComputational BiologyDepressive Disorder, MajorFemaleFetal DevelopmentGene Regulatory NetworksGenotypeGestational AgeHumansImage Processing, Computer-AssistedInfant, NewbornMagnetic Resonance ImagingMaleMaternal-Fetal RelationsPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsSocial ClassConceptsMaternal depressive symptomsDepressive symptomsHippocampal volumeRight amygdalaRight hippocampal volumeGlutamate receptor activityNeonatal brain developmentMajor depressive disorderRight amygdala volumeMother-infant dyadsFetal neurodevelopmentAmericas cohortAsian cohortDepressive disorderNeurotrophic signalingRight hippocampusCognitive-emotional functionRisk scoreAmygdala volumeSignificant interactionFetal developmentVentromedial prefrontal cortexSocio-economic statusBrain regionsReceptor activity