2021
Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife
Shenk CE, Felt JM, Ram N, O'Donnell KJ, Sliwinski MJ, Pokhvisneva I, Benson L, Meaney MJ, Putnam FW, Noll JG. Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife. Psychoneuroendocrinology 2021, 136: 105606. PMID: 34896740, PMCID: PMC8724404, DOI: 10.1016/j.psyneuen.2021.105606.Peer-Reviewed Original ResearchConceptsEarly life adversityEpigenetic age accelerationChildhood sexual abuseCortisol trajectoriesLife adversityAge accelerationCortisol concentrationsBiological embedding modelProspective cohort studyPeak cortisol levelsHPA axis activitySubstantiated childhood sexual abuseEarly ageCohort studyAdulthood healthHPA axisAdrenal axisCortisol secretionCsA exposureCortisol levelsPotential indicationsSexual abuseMultiple biological systemsSubsequent occasionsBiological embedding
2016
Stress hormones and posttraumatic stress symptoms following paediatric critical illness: an exploratory study
Als LC, Picouto MD, O’Donnell K, Nadel S, Cooper M, Pierce CM, Kramer T, Glover VAS, Garralda ME. Stress hormones and posttraumatic stress symptoms following paediatric critical illness: an exploratory study. European Child & Adolescent Psychiatry 2016, 26: 511-519. PMID: 27995329, PMCID: PMC5394132, DOI: 10.1007/s00787-016-0933-3.Peer-Reviewed Original ResearchConceptsPediatric critical illnessPosttraumatic stress symptomsCritical illnessHealthy controlsEvening cortisolCortisol concentrationsExploratory case-control studyStress symptomsModest independent predictorCase-control studyEvening cortisol concentrationsBasal cortisol concentrationsPICU admissionPICU groupIndependent predictorsSeptic illnessSymptoms of PTSDSignificant positive associationStudy of childrenPrimary analysisMultivariate analysisSecondary analysisCortisol regulationConsecutive weekdaysStress hormones