2023
Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders
Felt J, Yusupov N, Harrington K, Fietz J, Zhang Z, Sliwinski M, Ram N, O'Donnell K, Group B, Meaney M, Putnam F, Noll J, Binder E, Shenk C. Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders. Neurobiology Of Stress 2023, 27: 100577. PMID: 37885906, PMCID: PMC10597797, DOI: 10.1016/j.ynstr.2023.100577.Peer-Reviewed Original ResearchEarly life adversityPsychiatric disordersEpigenetic age accelerationLife adversityAge accelerationProspective cohort studyBiological agingNon-abused controlsCohort studyNeurocognitive screeningPeripheral bloodCommunity cohortNeurocognitive declineIndependent cohortCognitive declineEarly screeningMental disordersCohortGrimAge clockDisordersBiomarkersLower general cognitive abilityEarly declineNeurocognitive abilitiesCognitive abilitiesPerinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents
Kee M, Cremaschi A, De Iorio M, Chen H, Montreuil T, Nguyen T, Côté S, O’Donnell K, Giesbrecht G, Letourneau N, Chan S, Meaney M. Perinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents. JAMA Network Open 2023, 6: e2339942. PMID: 37883082, PMCID: PMC10603499, DOI: 10.1001/jamanetworkopen.2023.39942.Peer-Reviewed Original ResearchConceptsSelf-reported depressive symptomsMaternal depressive symptomsDepressive symptomsPerinatal periodPostnatal periodEdinburgh Postnatal Depression ScalePostnatal Depression ScaleEpidemiological Studies DepressionHealth policy guidelinesPublic health initiativesGroups of mothersCohort studyObservational cohortProspective cohortPregnancy influencesReferral guidelinesMultiple time pointsDepression ScaleMAIN OUTCOMEPregnancyPostnatal onsetStudies DepressionHealth initiativesTimely interventionCohort
2022
Specific and cumulative lifetime stressors in the aetiology of major depression: A longitudinal community-based population study
Su Y, D'Arcy C, Li M, O'Donnell K, Caron J, Meaney M, Meng X. Specific and cumulative lifetime stressors in the aetiology of major depression: A longitudinal community-based population study. Epidemiology And Psychiatric Sciences 2022, 31: e3. PMID: 35078547, PMCID: PMC8851045, DOI: 10.1017/s2045796021000779.Peer-Reviewed Original ResearchConceptsGenetic predispositionSubsequent depressionStressful life eventsLifetime stressorsLongitudinal community-based cohort studyPsychosocial stressorsCommunity-based cohort studyCommunity-based population studyStressful eventsMental illness preventionMultivariate logistic regressionHealth-related factorsDevelopment of depressionChildhood maltreatmentMental health promotionEtiology of depressionPresent studyStressful experiencesLife eventsChild-parent bondingCumulative stressful experiencesSouthwest of MontrealPolygenetic risk scoresCohort studySocio-demographic characteristics
2021
Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife
Shenk CE, Felt JM, Ram N, O'Donnell KJ, Sliwinski MJ, Pokhvisneva I, Benson L, Meaney MJ, Putnam FW, Noll JG. Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife. Psychoneuroendocrinology 2021, 136: 105606. PMID: 34896740, PMCID: PMC8724404, DOI: 10.1016/j.psyneuen.2021.105606.Peer-Reviewed Original ResearchConceptsEarly life adversityEpigenetic age accelerationChildhood sexual abuseCortisol trajectoriesLife adversityAge accelerationCortisol concentrationsBiological embedding modelProspective cohort studyPeak cortisol levelsHPA axis activitySubstantiated childhood sexual abuseEarly ageCohort studyAdulthood healthHPA axisAdrenal axisCortisol secretionCsA exposureCortisol levelsPotential indicationsSexual abuseMultiple biological systemsSubsequent occasionsBiological embeddingInternalizing symptoms associate with the pace of epigenetic aging in childhood
Tollenaar MS, Beijers R, Garg E, Nguyen TTT, Lin DTS, MacIsaac JL, Shalev I, Kobor MS, Meaney MJ, O'Donnell KJ, de Weerth C. Internalizing symptoms associate with the pace of epigenetic aging in childhood. Biological Psychology 2021, 159: 108021. PMID: 33460784, DOI: 10.1016/j.biopsycho.2021.108021.Peer-Reviewed Original ResearchConceptsAdvanced biological agingChildhood psychiatric symptomsAge 6Longitudinal cohort studyInternalizing symptomsBiological agingChild mental healthCohort studyBuccal epithelial cellsPsychiatric symptomsSymptomsMental healthEpithelial cellsInternalizing disordersStatistical significanceAge 2.5Highest EAAExternalizing symptomsChildhoodEpigenetic agingHorvath clockGenome-wide DNA methylationEAA