2023
Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores
Chen L, Pokhvisneva I, Lahti-Pulkkinen M, Kvist T, Baldwin J, Parent C, Silveira P, Lahti J, Räikkönen K, Glover V, O'Connor T, Meaney M, O'Donnell K. Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 63: 640-651. PMID: 37977417, PMCID: PMC11105503, DOI: 10.1016/j.jaac.2023.08.018.Peer-Reviewed Original ResearchPrenatal maternal depressionMaternal mental healthMaternal depressionAttention-deficit/hyperactivity disorderChild psychiatric symptomsPolygenic risk scoresPsychiatric symptomsRisk scoreMental healthFetal originGenomic riskAvon Longitudinal StudySimilar independent effectsAdolescent psychiatric symptomsHealth hypothesisMaternal symptomsChild CohortIndependent cohortBehavioral symptomsALSPAC cohortMental disordersSymptom dataSymptomsCohortChildren's symptoms
2020
Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder
Chen LM, Tollenaar MS, Dass S, Bouvette-Turcot AA, Pokhvisneva I, Gaudreau H, Parent C, Diorio J, McEwen LM, MacIsaac JL, Kobor MS, Beijers R, de Weerth C, Silveira PP, Karama S, Meaney MJ, O'Donnell KJ. Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder. Development And Psychopathology 2020, 32: 1810-1821. PMID: 33427178, DOI: 10.1017/s0954579420001418.Peer-Reviewed Original ResearchConceptsMaternal antenatal depressionAttention-deficit/hyperactivity disorderAntenatal depressionChild mental healthPolygenic risk scoresMental healthHyperactivity disorderChild mental health symptomsMental health symptomsConsiderable inter-individual variationConventional polygenic risk scoresMaternal depressionRisk scoreHealth symptomsReplication cohortSynaptic functionGenomic riskChild genetic variationInter-individual variationNeuronal developmentSimilar findingsDepressionSingle nucleotide polymorphismsDevelopmental originsBehavioral problems