A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
Arcego D, Buschdorf J, O'Toole N, Wang Z, Barth B, Pokhvisneva I, Rayan N, Patel S, de Mendonça Filho E, Lee P, Tan J, Koh M, Sim C, Parent C, de Lima R, Clappison A, O'Donnell K, Dalmaz C, Arloth J, Provençal N, Binder E, Diorio J, Silveira P, Meaney M. A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. Biological Psychiatry 2023, 95: 48-61. PMID: 37406925, DOI: 10.1016/j.biopsych.2023.06.028.Peer-Reviewed Original ResearchConceptsHippocampal dentate gyrusDentate gyrusPsychiatric disordersHuman hippocampal cellsBrain gray matter densityEarly adversitySingle nucleotide polymorphismsMultiple psychiatric conditionsEarly life adversityGray matter densityAdult female macaquesMental health outcomesTranscriptional activityGlucocorticoid exposureNucleotide polymorphismsLater psychosisStress mediatorsHippocampal cellsPsychotic disordersAnimal modelsHealth outcomesPsychiatric conditionsSignificant associationFemale macaquesMental healthMaternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?
Creasey N, Beijers R, O'Donnell K, de Weerth C, Tollenaar M. Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Development And Psychopathology 2023, 36: 967-978. PMID: 36896668, DOI: 10.1017/s0954579423000226.Peer-Reviewed Original ResearchAge 5 weeksChild mental healthMaternal sensitivityMental healthGlucocorticoid receptor gene methylationAge 6 yearsChildren's internalizingMethylation levelsMother-infant interactionDNA methylation levelsAnimal modelsEarly infancyStress regulatory systemsExternalizing behaviorsEarly caregiving environmentGene DNA methylationAge 6Longitudinal studyLower DNA methylation levelsResponsive caregivingSame childrenCommunity sampleCaregiving environmentGene methylationDNA methylation