2020
Tissue plasminogen activator mobilizes neutrophils and T cells that exacerbate hemorrhagic transformation in stroke
Shi K, Liu Q, Jia D, Yang X, Zou M, Shi S, Dong J, Sheth K, Wang X, Shi F. Tissue plasminogen activator mobilizes neutrophils and T cells that exacerbate hemorrhagic transformation in stroke. The Journal Of Immunology 2020, 204: 64.21-64.21. DOI: 10.4049/jimmunol.204.supp.64.21.Peer-Reviewed Original ResearchTissue plasminogen activatorT cellsEmbolic strokeHemorrhagic transformationNeurovascular unitThrombolytic therapyBrain hemorrhageEffects of tPAPlasminogen activatorFocal embolic strokeIschemic stroke patientsMyeloid cell recruitmentMigration of neutrophilsTPA thrombolysisHemorrhagic complicationsIschemic strokeLymphocyte egressEndothelial injuryNeurological functionStroke patientsImmune modulationRat modelCell recruitmentImmune invasionNeutrophils
2017
Chapter 10 Sur1–Trpm4-Promising Target for Brain Edema Treatment in Brain Edema From Molecular Mechanisms to Clinical Practice
Urday S, Sheth K, Simard J. Chapter 10 Sur1–Trpm4-Promising Target for Brain Edema Treatment in Brain Edema From Molecular Mechanisms to Clinical Practice. 2017, 183-198. DOI: 10.1016/b978-0-12-803196-4.00010-2.Peer-Reviewed Original ResearchSUR1-TRPM4Brain edemaEdema formationDefinitive phase III studyBrain edema treatmentNeurocritical care conditionsPhase III studyAcute neurological injuryExtravasation of bloodType of edemaMicrovascular failureIII studySignificant morbidityNeurological functionNeurological injuryEdema treatmentSafe medicationSelective blockadeLesion volumeClinical studiesPetechial hemorrhagesCare conditionsEdemaClinical practiceSulfonylurea receptor