2017
Mecamylamine treatment for alcohol dependence: a randomized controlled trial
Petrakis IL, Ralevski E, Gueorguieva R, O'Malley SS, Arias A, Sevarino KA, Jane JS, O'Brien E, Krystal JH. Mecamylamine treatment for alcohol dependence: a randomized controlled trial. Addiction 2017, 113: 6-14. PMID: 28710873, PMCID: PMC5725262, DOI: 10.1111/add.13943.Peer-Reviewed Original ResearchConceptsHeavy drinking daysDrinking daysAlcohol use disorderUse disordersAlcohol consumptionAlcohol dependenceDouble-blind clinical trialNicotinic acetylcholine receptor antagonistWeeks of treatmentAcetylcholine receptor antagonistCurrent alcohol dependenceSignificant differencesTreatment-seeking smokersMecamylamine treatmentPlacebo groupMonth 3Primary outcomeSmoking statusNicotine withdrawalReceptor antagonistNovel pharmacotherapiesClinical trialsManagement therapyMecamylamineTreatment groups
2005
Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients
Oliveto A, Poling J, Sevarino K, Gonsai K, McCance-Katz E, Stine S, Kosten T. Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients. Drug And Alcohol Dependence 2005, 79: 157-165. PMID: 16002025, DOI: 10.1016/j.drugalcdep.2005.01.007.Peer-Reviewed Original ResearchConceptsHC groupOpioid useContingency management proceduresCocaine useEfficacy of DoseOverall opioid useOpioid withdrawal symptomsHigh-dose groupLow-dose groupLY groupDrug-free urineCocaine-dependent patientsCocaine-dependent participantsBaseline characteristicsMaintenance doseWithdrawal symptomsClinical trialsCocaine abstinenceOpioidsLAAMUrine samplesHY groupAbstinenceDoseUrine
2003
Tiagabine increases cocaine‐free urines in cocaine‐dependent methadone‐treated patients: results of a randomized pilot study
Gonzalez G, Sevarino K, Sofuoglu M, Poling J, Oliveto A, Gonsai K, George TP, Kosten TR. Tiagabine increases cocaine‐free urines in cocaine‐dependent methadone‐treated patients: results of a randomized pilot study. Addiction 2003, 98: 1625-1632. PMID: 14616189, DOI: 10.1046/j.1360-0443.2003.00544.x.Peer-Reviewed Original ResearchConceptsMethadone-treated patientsCocaine-free urinesUrine drug testsDouble-blind placebo-controlled trialCocaine useVeterans Affairs Connecticut Healthcare SystemPlacebo-controlled trialDrug testsRandomized pilot studyOpiate Withdrawal ScaleStructured Clinical InterviewSelf-reported cocaine useTreatment Research ProgramAddiction Severity IndexGABAergic medicationsActive medicationStudy entrySelf-reported useWithdrawal ScaleTreatment groupsTiagabineTreatment retentionAverage ageClinical InterviewWeek 9Desipramine and contingency management for cocaine and opiate dependence in buprenorphine maintained patients
Kosten T, Oliveto A, Feingold A, Poling J, Sevarino K, McCance-Katz E, Stine S, Gonzalez G, Gonsai K. Desipramine and contingency management for cocaine and opiate dependence in buprenorphine maintained patients. Drug And Alcohol Dependence 2003, 70: 315-325. PMID: 12757969, DOI: 10.1016/s0376-8716(03)00032-2.Peer-Reviewed Original ResearchConceptsCocaine-free urinesContingency managementCocaine useOpioid withdrawal symptomsUrine toxicology resultsDrug-free urineMethadone treatmentPoor prognosisWithdrawal symptomsMethadone maintenancePlasma levelsDependent patientsToxicology resultsTreatment groupsCell trialsCocaine abuseBuprenorphineDesipraminePatientsCocaine abusersOpiatesSymptom levelsUrineAdditive effectCocaine
2002
Ketoconazole increases cocaine and opioid use in methadone maintained patients
Kosten T, Oliveto A, Sevarino K, Gonsai K, Feingold A. Ketoconazole increases cocaine and opioid use in methadone maintained patients. Drug And Alcohol Dependence 2002, 66: 173-180. PMID: 11906804, DOI: 10.1016/s0376-8716(01)00198-3.Peer-Reviewed Original ResearchConceptsCortisol synthesis inhibitorOpioid usePlacebo treatmentCocaine useDouble-blind trialMorning cortisol levelsStress-induced reinstatementCocaine-related behaviorsSynthesis inhibitorSubstance abuse problemsMethadone treatmentWithdrawal symptomsKetoconazole treatmentPharmacological adrenalectomyClinical trialsBlind trialSide effectsCocaine abuseCortisol levelsMethadoneNormal valuesPatientsSubjective effectsKetoconazoleTreatment implications
2000
Comparison of intravenous cocaethylene and cocaine in humans
Hart C, Jatlow P, Sevarino K, McCance-Katz E. Comparison of intravenous cocaethylene and cocaine in humans. Psychopharmacology 2000, 149: 153-162. PMID: 10805610, DOI: 10.1007/s002139900363.Peer-Reviewed Original ResearchConceptsBlood pressureActive drug conditionsDouble-blind studyDiastolic blood pressureSystolic blood pressureTransesterification of cocaineCocaine-dependent participantsStudy drugMetabolite of cocaineHeart rateSlow clearanceDrug conditionsSeparate daysHuman volunteersSubjective effectsPharmacological propertiesEquivalent dosesCocainePlaceboSignificant increaseSimilar differencesCocaethyleneExperimental sessionsSubjective measuresPrevious studies