2002
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
Chatterton JE, Awobuluyi M, Premkumar LS, Takahashi H, Talantova M, Shin Y, Cui J, Tu S, Sevarino KA, Nakanishi N, Tong G, Lipton SA, Zhang D. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature 2002, 415: 793-798. PMID: 11823786, DOI: 10.1038/nature715.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCations, DivalentCentral Nervous SystemCloning, MolecularElectrophysiologyGlutamic AcidGlycineImmunohistochemistryIn Situ HybridizationIon TransportMagnesiumMolecular Sequence DataNeuronsN-MethylaspartateOocytesProtein SubunitsRatsReceptors, GlycineReceptors, N-Methyl-D-AspartateRNA, MessengerSequence HomologySerineSubstrate SpecificityXenopus laevisConceptsExcitatory glycine receptorsGlycine receptorsN-methyl-D-aspartate (NMDA) subtypeD-serineCentral nervous systemNMDA receptor subunitsImpermeable cation channelsVoltage-dependent inhibitionBursts of firingMK-801Inhibitory neurotransmitterMotor neuronsGlutamate receptorsCerebrocortical neuronsCompetitive antagonistNervous systemDual agonistsNMDARNMDAR familyReceptor subunitsNeuronal developmentPathological processesCation channelsReceptorsNR3A
1995
Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family
Ciabarra A, Sullivan J, Gahn L, Pecht G, Heinemann S, Sevarino K. Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. Journal Of Neuroscience 1995, 15: 6498-6508. PMID: 7472412, PMCID: PMC6577996, DOI: 10.1523/jneurosci.15-10-06498.1995.Peer-Reviewed Original ResearchConceptsAgonist-activated currentsGlutamate receptor subunitsIonotropic glutamate receptor familyGlutamate receptor familyReceptor subunitsReceptor familyPostnatal day 1First postnatal weekNMDA receptor subunitsFunctional NMDA receptorsIonotropic glutamate receptorsSpinal cordCA1 fieldHeteromeric configurationsNMDA receptorsGlutamate receptorsPostnatal weekNMDA subunitsDay 1Functional expression studiesNeuronal signalingPrecise roleReceptorsTranscript levelsXenopus oocytes
1991
Multiple preprosomatostatin sorting signals mediate secretion via discrete cAMP- and tetradecanoylphorbolacetate-responsive pathways.
Sevarino K, Stork P. Multiple preprosomatostatin sorting signals mediate secretion via discrete cAMP- and tetradecanoylphorbolacetate-responsive pathways. Journal Of Biological Chemistry 1991, 266: 18507-18513. PMID: 1680862, DOI: 10.1016/s0021-9258(18)55090-0.Peer-Reviewed Original ResearchConceptsRegulated secretory pathwaySecretory pathwayMutant precursorRat preprosomatostatinVesicular stomatitis virus G proteinMature peptide regionVirus G proteinSorting signalsRegulated secretionAmino terminusProteolytic maturationExpression vectorNeuropeptide precursorsSite recognitionG proteinsRIN-5F cellsPeptide regionPathwaySecreted productsMutationsIntracellular productsCellsEndocrine cellsResidues
1990
Processing and intracellular sorting of anglerfish and rat preprosomatostatins in mammalian endocrine cells
Sevarino K, Ventimiglia R, Stork P. Processing and intracellular sorting of anglerfish and rat preprosomatostatins in mammalian endocrine cells. Metabolism 1990, 39: 26-29. PMID: 1976215, DOI: 10.1016/0026-0495(90)90203-o.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCloning, MolecularFishesMutationProtein PrecursorsRatsSomatostatinSpecies Specificity
1989
Characterization and Expression of the Gene‐Encoding Rat Thyrotropin‐Releasing Hormone (TRH)
LEE S, SEVARINO K, ROOS B, GOODMAN R. Characterization and Expression of the Gene‐Encoding Rat Thyrotropin‐Releasing Hormone (TRH). Annals Of The New York Academy Of Sciences 1989, 553: 14-28. PMID: 2497670, DOI: 10.1111/j.1749-6632.1989.tb54475.x.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBase SequenceBlotting, NorthernBlotting, SouthernBrainCloning, MolecularDNAEnhancer Elements, GeneticGenesMolecular Sequence DataOrgan SpecificityPromoter Regions, GeneticProtein PrecursorsRatsRecombinant Fusion ProteinsRestriction MappingRNA, MessengerThyrotropin-Releasing HormoneTransfection