1999
The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides*
Nillni E, Sevarino K. The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides*. Endocrine Reviews 1999, 20: 599-648. PMID: 10529897, DOI: 10.1210/edrv.20.5.0379.Peer-Reviewed Original Research
1997
An anti-χ-1 antibody recognizes a heavily glycosylated protein in rat brain
Ciabarra A, Sevarino K. An anti-χ-1 antibody recognizes a heavily glycosylated protein in rat brain. Brain Research 1997, 46: 85-90. PMID: 9191081, DOI: 10.1016/s0169-328x(96)00275-6.Peer-Reviewed Original Research
1996
Preprothyrotropin-releasing hormone mRNA in the rat central gray is strongly and persistently induced during morphine withdrawal
Gahn L, Sevarino K. Preprothyrotropin-releasing hormone mRNA in the rat central gray is strongly and persistently induced during morphine withdrawal. Neuropeptides 1996, 30: 207-212. PMID: 8819143, DOI: 10.1016/s0143-4179(96)90065-7.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneVentrolateral central grayCentral grayOpiate withdrawalMorphine withdrawalAcute naltrexone treatmentPrecipitation of withdrawalHormone mRNAChronic morphineNaltrexone treatmentSystemic administrationOpiate dependencePhysical symptomsVivo evidenceWithdrawalMorphineSignificant increaseRatsSitu hybridizationMRNA
1995
Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family
Ciabarra A, Sullivan J, Gahn L, Pecht G, Heinemann S, Sevarino K. Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. Journal Of Neuroscience 1995, 15: 6498-6508. PMID: 7472412, PMCID: PMC6577996, DOI: 10.1523/jneurosci.15-10-06498.1995.Peer-Reviewed Original ResearchConceptsAgonist-activated currentsGlutamate receptor subunitsIonotropic glutamate receptor familyGlutamate receptor familyReceptor subunitsReceptor familyPostnatal day 1First postnatal weekNMDA receptor subunitsFunctional NMDA receptorsIonotropic glutamate receptorsSpinal cordCA1 fieldHeteromeric configurationsNMDA receptorsGlutamate receptorsPostnatal weekNMDA subunitsDay 1Functional expression studiesNeuronal signalingPrecise roleReceptorsTranscript levelsXenopus oocytesRegulation of Cytochrome c Oxidase Subunit mRNA and Enzyme Activity in Rat Brain Reward Regions During Withdrawal from Chronic Cocaine
Walker J, Sevarino K. Regulation of Cytochrome c Oxidase Subunit mRNA and Enzyme Activity in Rat Brain Reward Regions During Withdrawal from Chronic Cocaine. Journal Of Neurochemistry 1995, 64: 497-502. PMID: 7830041, DOI: 10.1046/j.1471-4159.1995.64020497.x.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexNucleus accumbensBrain regionsChronic cocaine treatmentCO activityChronic treatmentCocaine treatmentBrain reward regionsChronic cocaineDrug rewardPrefrontal cortexSubunit mRNAsIndividual ratsReward regionsCocaineNorthern blot analysisBlot analysisTime-dependent patternUnique time-dependent patternEnzyme activityRatsScreening procedureTreatmentMRNAMetabolic activity
1993
Cocaine Regulation of Brain Preprothyrotropin‐Releasing Hormone mRNA
Sevarino K, Primus R. Cocaine Regulation of Brain Preprothyrotropin‐Releasing Hormone mRNA. Journal Of Neurochemistry 1993, 60: 1151-1154. PMID: 8436966, DOI: 10.1111/j.1471-4159.1993.tb03267.x.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneCocaine treatmentNucleus accumbensCocaine actionSolution hybridization RNase protectionMRNA levelsRat brain regionsChronic cocaine treatmentAcute cocaine treatmentPreclinical evidenceExtrahypothalamic regionsCocaine withdrawalMin postinjectionH postinjectionPrepro-TRHBrain regionsCocaine regulationCocaine reinforcementAmygdalaThalamusTRH precursorHippocampusHormone mRNASignificant decreaseRNase protection
1991
A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function
Terwilliger R, Beitner-Johnson D, Sevarino K, Crain S, Nestler E. A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Research 1991, 548: 100-110. PMID: 1651140, DOI: 10.1016/0006-8993(91)91111-d.Peer-Reviewed Original ResearchConceptsCyclic AMP systemChronic morphineNucleus accumbensBrain regionsAdenylate cyclaseAMP systemDorsal root ganglion/spinal cordG proteinsRat locus coeruleusMorphine regulationChronic treatmentLocus coeruleusSpinal cordChronic actionsOpiate toleranceAbused substancesMorphineAMP-dependent protein kinase activityCyclic AMP-dependent protein kinase activityNeuronal functionKinase activityDecreased levelsDrug addictionCocaineThalamus
1990
Chronic Cocaine Treatment Decreases Levels of the G Protein Subunits Giα and Goα in Discrete Regions of Rat Brain
Nestler E, Terwilliger R, Walker J, Sevarino K, Duman R. Chronic Cocaine Treatment Decreases Levels of the G Protein Subunits Giα and Goα in Discrete Regions of Rat Brain. Journal Of Neurochemistry 1990, 55: 1079-1082. PMID: 2117048, DOI: 10.1111/j.1471-4159.1990.tb04602.x.Peer-Reviewed Original ResearchConceptsVentral tegmental areaChronic cocaineTegmental areaNucleus accumbensBrain regionsLocus coeruleusGi alphaPertussis toxin-mediated ADP-ribosylationRat brain regionsTreatment of ratsG proteinsG protein ADP-ribosylationADP-ribosylation levelsElectrophysiological actionsBeta immunoreactivityADP-ribosylationChronic actionsRat brainCocaine actionGs alphaDecrease levelsAlpha levelsAccumbensImmunoreactivityCocaine
1989
Characterization and Expression of the Gene‐Encoding Rat Thyrotropin‐Releasing Hormone (TRH)
LEE S, SEVARINO K, ROOS B, GOODMAN R. Characterization and Expression of the Gene‐Encoding Rat Thyrotropin‐Releasing Hormone (TRH). Annals Of The New York Academy Of Sciences 1989, 553: 14-28. PMID: 2497670, DOI: 10.1111/j.1749-6632.1989.tb54475.x.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBase SequenceBlotting, NorthernBlotting, SouthernBrainCloning, MolecularDNAEnhancer Elements, GeneticGenesMolecular Sequence DataOrgan SpecificityPromoter Regions, GeneticProtein PrecursorsRatsRecombinant Fusion ProteinsRestriction MappingRNA, MessengerThyrotropin-Releasing HormoneTransfection