1991
A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function
Terwilliger R, Beitner-Johnson D, Sevarino K, Crain S, Nestler E. A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Research 1991, 548: 100-110. PMID: 1651140, DOI: 10.1016/0006-8993(91)91111-d.Peer-Reviewed Original ResearchConceptsCyclic AMP systemChronic morphineNucleus accumbensBrain regionsAdenylate cyclaseAMP systemDorsal root ganglion/spinal cordG proteinsRat locus coeruleusMorphine regulationChronic treatmentLocus coeruleusSpinal cordChronic actionsOpiate toleranceAbused substancesMorphineAMP-dependent protein kinase activityCyclic AMP-dependent protein kinase activityNeuronal functionKinase activityDecreased levelsDrug addictionCocaineThalamus
1990
Chronic Cocaine Treatment Decreases Levels of the G Protein Subunits Giα and Goα in Discrete Regions of Rat Brain
Nestler E, Terwilliger R, Walker J, Sevarino K, Duman R. Chronic Cocaine Treatment Decreases Levels of the G Protein Subunits Giα and Goα in Discrete Regions of Rat Brain. Journal Of Neurochemistry 1990, 55: 1079-1082. PMID: 2117048, DOI: 10.1111/j.1471-4159.1990.tb04602.x.Peer-Reviewed Original ResearchConceptsVentral tegmental areaChronic cocaineTegmental areaNucleus accumbensBrain regionsLocus coeruleusGi alphaPertussis toxin-mediated ADP-ribosylationRat brain regionsTreatment of ratsG proteinsG protein ADP-ribosylationADP-ribosylation levelsElectrophysiological actionsBeta immunoreactivityADP-ribosylationChronic actionsRat brainCocaine actionGs alphaDecrease levelsAlpha levelsAccumbensImmunoreactivityCocaine