Pharmacotherapy of stimulant dependence: one of Japan's greatest public health challenges.
McCance-Katz E, Sevarino K, Gottschalk P, Kosten T. Pharmacotherapy of stimulant dependence: one of Japan's greatest public health challenges. Neuropsychopharmacology Reports 1999, 19: 159-86. PMID: 10637824.Peer-Reviewed Original ResearchConceptsGreatest public health challengesMedication approachesExcitatory amino acid antagonistsMajor public health problemStimulant dependenceDopamine beta-hydroxylase inhibitorCerebral perfusion defectsRelease of EAAsCerebral perfusion abnormalitiesBeta-hydroxylase inhibitorAmino acid antagonistsPublic health problemPreliminary human studiesPublic health challengeCocaine-dependent patientsUptake of cocaineBlockade treatmentAntiplatelet therapyAntidepressant treatmentCatecholamine deficiencyCerebral ischemiaEAA antagonistsNeuronal damageCommon pathophysiologySubstitution therapy