2000
Comparison of intravenous cocaethylene and cocaine in humans
Hart C, Jatlow P, Sevarino K, McCance-Katz E. Comparison of intravenous cocaethylene and cocaine in humans. Psychopharmacology 2000, 149: 153-162. PMID: 10805610, DOI: 10.1007/s002139900363.Peer-Reviewed Original ResearchConceptsBlood pressureActive drug conditionsDouble-blind studyDiastolic blood pressureSystolic blood pressureTransesterification of cocaineCocaine-dependent participantsStudy drugMetabolite of cocaineHeart rateSlow clearanceDrug conditionsSeparate daysHuman volunteersSubjective effectsPharmacological propertiesEquivalent dosesCocainePlaceboSignificant increaseSimilar differencesCocaethyleneExperimental sessionsSubjective measuresPrevious studies
1996
Preprothyrotropin-releasing hormone mRNA in the rat central gray is strongly and persistently induced during morphine withdrawal
Gahn L, Sevarino K. Preprothyrotropin-releasing hormone mRNA in the rat central gray is strongly and persistently induced during morphine withdrawal. Neuropeptides 1996, 30: 207-212. PMID: 8819143, DOI: 10.1016/s0143-4179(96)90065-7.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneVentrolateral central grayCentral grayOpiate withdrawalMorphine withdrawalAcute naltrexone treatmentPrecipitation of withdrawalHormone mRNAChronic morphineNaltrexone treatmentSystemic administrationOpiate dependencePhysical symptomsVivo evidenceWithdrawalMorphineSignificant increaseRatsSitu hybridizationMRNA