2002
Butorphanol and nalbuphine in opioid-dependent humans under a naloxone discrimination procedure
Oliveto A, Sevarino K, McCance-Katz E, Feingold A. Butorphanol and nalbuphine in opioid-dependent humans under a naloxone discrimination procedure. Pharmacology Biochemistry And Behavior 2002, 71: 85-96. PMID: 11812511, DOI: 10.1016/s0091-3057(01)00637-2.Peer-Reviewed Original ResearchConceptsNaloxone-appropriate respondingOpioid antagonist naloxoneDose-related increaseAntagonist naloxoneNovel-response drug discrimination procedureOpioid agonist/antagonistOpioid-dependent humansDoses of naloxoneDiscriminative stimulus effectsDrug discrimination procedureAgonists/antagonistsAppropriate respondingLow doseHigh doseNaloxoneSelf-reported effectsDiscrimination procedureDrug conditionsHigh dosesNalbuphineButorphanolDosesDoseRespondingPlacebo
2000
Comparison of intravenous cocaethylene and cocaine in humans
Hart C, Jatlow P, Sevarino K, McCance-Katz E. Comparison of intravenous cocaethylene and cocaine in humans. Psychopharmacology 2000, 149: 153-162. PMID: 10805610, DOI: 10.1007/s002139900363.Peer-Reviewed Original ResearchConceptsBlood pressureActive drug conditionsDouble-blind studyDiastolic blood pressureSystolic blood pressureTransesterification of cocaineCocaine-dependent participantsStudy drugMetabolite of cocaineHeart rateSlow clearanceDrug conditionsSeparate daysHuman volunteersSubjective effectsPharmacological propertiesEquivalent dosesCocainePlaceboSignificant increaseSimilar differencesCocaethyleneExperimental sessionsSubjective measuresPrevious studies