Neurobiological Adaptations to Psychostimulants and Opiates as a Basis of Treatment Development
SEVARINO K, OLIVETO A, KOSTEN T. Neurobiological Adaptations to Psychostimulants and Opiates as a Basis of Treatment Development. Annals Of The New York Academy Of Sciences 2000, 909: 51-87. PMID: 10911924, DOI: 10.1111/j.1749-6632.2000.tb06676.x.Peer-Reviewed Original ResearchConceptsOpiate withdrawalLocus coeruleus noradrenergic neuronsWorldwide public health issueTreatment developmentNeurobiological adaptationsCerebral perfusion abnormalitiesTrials of antidepressantsPublic health issueNew treatment developmentCocaine vaccineAntagonist therapyNoradrenergic neuronsHeroin effectsChronic usePerfusion abnormalitiesSerotonin neurotransmissionOpiate dependenceClinical experienceOpiate maintenanceCocaine dependenceBehavioral treatmentOpiate addictionIllicit substancesHealth issuesPsychostimulants