The Thyrotropin-Releasing Hormone (TRH) Hypothesis of Homeostatic Regulation: Implications for TRH-Based Therapeutics
Gary K, Sevarino K, Yarbrough G, Prange A, Winokur A. The Thyrotropin-Releasing Hormone (TRH) Hypothesis of Homeostatic Regulation: Implications for TRH-Based Therapeutics. Journal Of Pharmacology And Experimental Therapeutics 2003, 305: 410-416. PMID: 12606661, DOI: 10.1124/jpet.102.044040.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneCentral nervous systemAction of TRHTherapeutic agentsSpinal cord systemsTherapeutic benefitTRH analogNervous systemClinical situationsCNS activityNeuroendocrine systemHormone hypothesisMetabolic homeostasisCortical systemsHuman illnessMyriad actionsHomeostatic regulationNeurobiological functionsDrugsHomeostatic systemGlobal functionManifold actionsChronobiological systemHomeostasisBroad spectrum