Clonidine and yohimbine in opioid-dependent humans responding under a naloxone novel-response discrimination procedure
Oliveto A, Sevarino K, McCance-Katz E, Benios T, Poling J, Feingold A. Clonidine and yohimbine in opioid-dependent humans responding under a naloxone novel-response discrimination procedure. Behavioural Pharmacology 2003, 14: 97-109. PMID: 12658070, DOI: 10.1097/00008877-200303000-00001.Peer-Reviewed Original ResearchConceptsAlpha2-adrenergic antagonist yohimbineNovel-response drug discrimination procedureAlpha2-adrenergic agonist clonidineOpioid-dependent humansPlacebo-appropriate respondingOpioid antagonist naloxoneClonidine-induced changesDose-related increaseEffects of yohimbineDoses of naloxoneDrug discrimination procedureOpioid withdrawalAdrenergic mechanismsAntagonist yohimbineAgonist clonidineAntagonist naloxoneOpioid antagonistClonidineLow doseNaloxoneTraining doseYohimbineDrug conditionsDiscrimination procedureDose