2017
Mecamylamine treatment for alcohol dependence: a randomized controlled trial
Petrakis IL, Ralevski E, Gueorguieva R, O'Malley SS, Arias A, Sevarino KA, Jane JS, O'Brien E, Krystal JH. Mecamylamine treatment for alcohol dependence: a randomized controlled trial. Addiction 2017, 113: 6-14. PMID: 28710873, PMCID: PMC5725262, DOI: 10.1111/add.13943.Peer-Reviewed Original ResearchConceptsHeavy drinking daysDrinking daysAlcohol use disorderUse disordersAlcohol consumptionAlcohol dependenceDouble-blind clinical trialNicotinic acetylcholine receptor antagonistWeeks of treatmentAcetylcholine receptor antagonistCurrent alcohol dependenceSignificant differencesTreatment-seeking smokersMecamylamine treatmentPlacebo groupMonth 3Primary outcomeSmoking statusNicotine withdrawalReceptor antagonistNovel pharmacotherapiesClinical trialsManagement therapyMecamylamineTreatment groups
2016
A Randomized Trial of Contingency Management for Smoking Cessation During Intensive Outpatient Alcohol Treatment
Cooney JL, Cooper S, Grant C, Sevarino K, Krishnan-Sarin S, Gutierrez IA, Cooney NL. A Randomized Trial of Contingency Management for Smoking Cessation During Intensive Outpatient Alcohol Treatment. Journal Of Substance Use And Addiction Treatment 2016, 72: 89-96. PMID: 27542442, DOI: 10.1016/j.jsat.2016.07.002.Peer-Reviewed Original ResearchConceptsEnd of treatmentNicotine replacement therapyOutpatient alcohol treatmentContingency managementReplacement therapyDependent smokersQuit ratesAbstinence outcomesAlcohol treatmentEfficacy of CMEvidence-based smoking cessation treatmentOutpatient alcohol treatment programOne monthAlcohol-dependent smokersInitial smoking abstinenceSmoking cessation treatmentDrug use outcomesAlcohol treatment programsCognitive behavioral therapyCognitive behavior therapyCessation treatmentRandomized trialsSmoking cessationSmoking abstinenceClinical trials
2009
Smoking cessation during alcohol treatment: a randomized trial of combination nicotine patch plus nicotine gum
Cooney NL, Cooney JL, Perry BL, Carbone M, Cohen EH, Steinberg HR, Pilkey DT, Sevarino K, Oncken CA, Litt MD. Smoking cessation during alcohol treatment: a randomized trial of combination nicotine patch plus nicotine gum. Addiction 2009, 104: 1588-1596. PMID: 19549054, PMCID: PMC2753831, DOI: 10.1111/j.1360-0443.2009.02624.x.Peer-Reviewed Original ResearchConceptsActive nicotine patchNicotine patchPlacebo gumNicotine gumSmoking cessationDouble-blind placebo-controlled clinical trialAlcohol treatmentPlacebo-controlled clinical trialBetter smoking outcomesCombination nicotine patchTransdermal nicotine patchDouble-blind conditionsSubstance abuse clinicsMonthly booster sessionsCombination nicotine replacementNicotine replacementCessation treatmentTobacco smokersLarge trialsCombination therapyMore cigarettesMedication conditionActive gumClinical trialsBooster sessions
2005
Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients
Oliveto A, Poling J, Sevarino K, Gonsai K, McCance-Katz E, Stine S, Kosten T. Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients. Drug And Alcohol Dependence 2005, 79: 157-165. PMID: 16002025, DOI: 10.1016/j.drugalcdep.2005.01.007.Peer-Reviewed Original ResearchConceptsHC groupOpioid useContingency management proceduresCocaine useEfficacy of DoseOverall opioid useOpioid withdrawal symptomsHigh-dose groupLow-dose groupLY groupDrug-free urineCocaine-dependent patientsCocaine-dependent participantsBaseline characteristicsMaintenance doseWithdrawal symptomsClinical trialsCocaine abstinenceOpioidsLAAMUrine samplesHY groupAbstinenceDoseUrine
2002
Ketoconazole increases cocaine and opioid use in methadone maintained patients
Kosten T, Oliveto A, Sevarino K, Gonsai K, Feingold A. Ketoconazole increases cocaine and opioid use in methadone maintained patients. Drug And Alcohol Dependence 2002, 66: 173-180. PMID: 11906804, DOI: 10.1016/s0376-8716(01)00198-3.Peer-Reviewed Original ResearchConceptsCortisol synthesis inhibitorOpioid usePlacebo treatmentCocaine useDouble-blind trialMorning cortisol levelsStress-induced reinstatementCocaine-related behaviorsSynthesis inhibitorSubstance abuse problemsMethadone treatmentWithdrawal symptomsKetoconazole treatmentPharmacological adrenalectomyClinical trialsBlind trialSide effectsCocaine abuseCortisol levelsMethadoneNormal valuesPatientsSubjective effectsKetoconazoleTreatment implications