2000
Neurobiological Adaptations to Psychostimulants and Opiates as a Basis of Treatment Development
SEVARINO K, OLIVETO A, KOSTEN T. Neurobiological Adaptations to Psychostimulants and Opiates as a Basis of Treatment Development. Annals Of The New York Academy Of Sciences 2000, 909: 51-87. PMID: 10911924, DOI: 10.1111/j.1749-6632.2000.tb06676.x.Peer-Reviewed Original ResearchConceptsOpiate withdrawalLocus coeruleus noradrenergic neuronsWorldwide public health issueTreatment developmentNeurobiological adaptationsCerebral perfusion abnormalitiesTrials of antidepressantsPublic health issueNew treatment developmentCocaine vaccineAntagonist therapyNoradrenergic neuronsHeroin effectsChronic usePerfusion abnormalitiesSerotonin neurotransmissionOpiate dependenceClinical experienceOpiate maintenanceCocaine dependenceBehavioral treatmentOpiate addictionIllicit substancesHealth issuesPsychostimulants
1999
Pharmacotherapy of stimulant dependence: one of Japan's greatest public health challenges.
McCance-Katz E, Sevarino K, Gottschalk P, Kosten T. Pharmacotherapy of stimulant dependence: one of Japan's greatest public health challenges. Neuropsychopharmacology Reports 1999, 19: 159-86. PMID: 10637824.Peer-Reviewed Original ResearchConceptsGreatest public health challengesMedication approachesExcitatory amino acid antagonistsMajor public health problemStimulant dependenceDopamine beta-hydroxylase inhibitorCerebral perfusion defectsRelease of EAAsCerebral perfusion abnormalitiesBeta-hydroxylase inhibitorAmino acid antagonistsPublic health problemPreliminary human studiesPublic health challengeCocaine-dependent patientsUptake of cocaineBlockade treatmentAntiplatelet therapyAntidepressant treatmentCatecholamine deficiencyCerebral ischemiaEAA antagonistsNeuronal damageCommon pathophysiologySubstitution therapy