2003
The Thyrotropin-Releasing Hormone (TRH) Hypothesis of Homeostatic Regulation: Implications for TRH-Based Therapeutics
Gary K, Sevarino K, Yarbrough G, Prange A, Winokur A. The Thyrotropin-Releasing Hormone (TRH) Hypothesis of Homeostatic Regulation: Implications for TRH-Based Therapeutics. Journal Of Pharmacology And Experimental Therapeutics 2003, 305: 410-416. PMID: 12606661, DOI: 10.1124/jpet.102.044040.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneCentral nervous systemAction of TRHTherapeutic agentsSpinal cord systemsTherapeutic benefitTRH analogNervous systemClinical situationsCNS activityNeuroendocrine systemHormone hypothesisMetabolic homeostasisCortical systemsHuman illnessMyriad actionsHomeostatic regulationNeurobiological functionsDrugsHomeostatic systemGlobal functionManifold actionsChronobiological systemHomeostasisBroad spectrum
2002
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
Chatterton JE, Awobuluyi M, Premkumar LS, Takahashi H, Talantova M, Shin Y, Cui J, Tu S, Sevarino KA, Nakanishi N, Tong G, Lipton SA, Zhang D. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature 2002, 415: 793-798. PMID: 11823786, DOI: 10.1038/nature715.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCations, DivalentCentral Nervous SystemCloning, MolecularElectrophysiologyGlutamic AcidGlycineImmunohistochemistryIn Situ HybridizationIon TransportMagnesiumMolecular Sequence DataN-MethylaspartateNeuronsOocytesProtein SubunitsRatsReceptors, GlycineReceptors, N-Methyl-D-AspartateRNA, MessengerSequence HomologySerineSubstrate SpecificityXenopus laevisConceptsExcitatory glycine receptorsGlycine receptorsN-methyl-D-aspartate (NMDA) subtypeD-serineCentral nervous systemNMDA receptor subunitsImpermeable cation channelsVoltage-dependent inhibitionBursts of firingMK-801Inhibitory neurotransmitterMotor neuronsGlutamate receptorsCerebrocortical neuronsCompetitive antagonistNervous systemDual agonistsNMDARNMDAR familyReceptor subunitsNeuronal developmentPathological processesCation channelsReceptorsNR3A