2009
Genetic Landscape of Eurasia and “Admixture” in Uyghurs
Li H, Cho K, Kidd JR, Kidd KK. Genetic Landscape of Eurasia and “Admixture” in Uyghurs. American Journal Of Human Genetics 2009, 85: 934-937. PMID: 20004770, PMCID: PMC2790568, DOI: 10.1016/j.ajhg.2009.10.024.Peer-Reviewed Original Research
2004
Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region
Paschou P, Feng Y, Pakstis A, Speed W, DeMille M, Kidd J, Jaghori B, Kurlan R, Pauls D, Sandor P, Barr C, Kidd K. Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region. American Journal Of Human Genetics 2004, 75: 545-560. PMID: 15303240, PMCID: PMC1182043, DOI: 10.1086/424389.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 17C-Reactive ProteinGene FrequencyGenetic LinkageGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLinkage DisequilibriumLod ScoreMicrosatellite RepeatsMicrotubule-Associated ProteinsNerve Tissue ProteinsPedigreePolymorphism, Single NucleotideTourette SyndromeWhite PeopleConceptsSingle nucleotide polymorphismsLinkage disequilibriumSusceptibility regionsThree-site haplotypesPutative susceptibility regionsBackground linkage disequilibriumSignificant association resultsIndication of linkageNonparametric LOD scoreGenomic regionsThree-marker haplotypeComplex genetic backgroundAdditional microsatellite markersFine mappingGenetic basisHigher LD valuesMicrosatellite markersExpression profilesAssociation resultsTransmission/disequilibrium testChromosome 17Genetic componentGenetic backgroundGenesLOD score
2000
Transmission/Disequilibrium Tests Using Multiple Tightly Linked Markers
Zhao H, Zhang S, Merikangas K, Trixler M, Wildenauer D, Sun F, Kidd K. Transmission/Disequilibrium Tests Using Multiple Tightly Linked Markers. American Journal Of Human Genetics 2000, 67: 936-946. PMID: 10968775, PMCID: PMC1287895, DOI: 10.1086/303073.Peer-Reviewed Original Research
1999
A paradigm for finding genes for a complex human trait: Polycystic ovary syndrome and follistatin
Odunsi K, Kidd K. A paradigm for finding genes for a complex human trait: Polycystic ovary syndrome and follistatin. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 8315-8317. PMID: 10411866, PMCID: PMC33617, DOI: 10.1073/pnas.96.15.8315.Peer-Reviewed Original Research
1997
Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes
Iyengar S, Calafell F, Kidd K. Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes. Genetic Epidemiology 1997, 14: 809-814. PMID: 9433582, DOI: 10.1002/(sici)1098-2272(1997)14:6<809::aid-gepi41>3.0.co;2-r.Peer-Reviewed Original Research
1996
Dynamics of the haplotype frequencies in populations: study using the Monte Carlo method.
Grigorenko E, Shikanian A, Kidd D, Dorig R, Kidd K. Dynamics of the haplotype frequencies in populations: study using the Monte Carlo method. Genetika 1996, 32: 1705-13. PMID: 9102365.Peer-Reviewed Original ResearchConceptsNatural selectionEffective population sizeRandom genetic driftMonte Carlo methodHaplotype frequenciesGenetic driftRandom matingEvolutionary dynamicsCarlo methodPopulation sizeRecurrent mutationsMutation processHarmonic meanFrequency dynamicsDifferent populationsSimulation resultsExperimental dataDynamicsMatingPopulationMutationsHaplotypesAllelesColonizationNew World colonizationDRD2 Haplotypes Containing the TaqI A1 Allele: Implications for Alcoholism Research
Kidd K, Pakstis A, Castiglione C, Kidd J, Speed W, Goldman D, Knowler W, Lu R, Bonne‐Tamir B. DRD2 Haplotypes Containing the TaqI A1 Allele: Implications for Alcoholism Research. Alcohol Clinical And Experimental Research 1996, 20: 697-705. PMID: 8800387, DOI: 10.1111/j.1530-0277.1996.tb01674.x.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAllelesAnimalsChromosome MappingDeoxyribonucleases, Type II Site-SpecificEthnicityGene FrequencyGenetics, PopulationHaplotypesHumansPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthReceptors, Dopamine D2Repetitive Sequences, Nucleic AcidResearchConceptsGenetic variationAssociation studiesUnrelated control samplesDopamine D2 receptor locusDiversity of haplotypesShort tandem repeat polymorphismsDRD2 locusEvolutionary historyRestriction fragment length polymorphismPopulation geneticsPhylogenetic originFragment length polymorphismAncestral originReceptor locusHomologous regionsIntron 2LociAllelic systemHigher primatesHaplotypesTandem repeat polymorphismAllelesConsiderable diversityDRD2 haplotypesPolymorphismChromosomal localization of long trinucleotide repeats in the human genome by fluorescence in situ hybridization
Haaf T, Sirugo G, Kidd K, Ward D. Chromosomal localization of long trinucleotide repeats in the human genome by fluorescence in situ hybridization. Nature Genetics 1996, 12: 183-185. PMID: 8563757, DOI: 10.1038/ng0296-183.Peer-Reviewed Original ResearchConceptsLong trinucleotide repeatsChromosomal localizationTrinucleotide repeatsHuman genomeNormal human genomeSitu hybridizationDifferent genetic diseasesUnstable trinucleotide repeatsChromosomal distributionTrinucleotide microsatellitesLarge repeatsAGG repeatsCCG repeatsRepeatsGenetic diseasesRepeat lociLarge CTG expansionsGenomeCTG expansionHybridizationPathological significanceMyotonic dystrophyMicrosatellitesLocalizationLociDNA Workbench: A Database Package to Manage Regional Physical Mapping
Nadkarni P, Cheung K, Castiglione C, Miller P, Kidd K. DNA Workbench: A Database Package to Manage Regional Physical Mapping. Journal Of Computational Biology 1996, 3: 319-329. PMID: 8811490, DOI: 10.1089/cmb.1996.3.319.Peer-Reviewed Original Research
1995
The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome
Gelernter J, Vandenbergh D, Kruger S, Pauls D, Kurlan R, Pakstis A, Kidd K, Uhl G. The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome. Genomics 1995, 30: 459-463. PMID: 8825631, DOI: 10.1006/geno.1995.1265.Peer-Reviewed Original ResearchConceptsTourette syndromeDopamine transporterAttention deficit disorderDopaminergic neuronsPresynaptic reuptakeSpecific localizationPsychiatric illnessPsychostimulant drugsChromosome 5pCocaine-induced paranoiaSyndromeDeficit disorderSLC6A3ScoresMajor siteLinkage studiesNegative lod scoresMarkersTransporter protein geneInternet-based Support for Bioscience Research: A Collaborative Genome center for Human Chromosome 12
Miller P, Nadkarni P, Kidd K, Cheung K, Ward D, Banks A, Bray-Ward P, Cupelli L, Herdman V, Marondel I, Montcomery K, Renault B, Yoon S, Krauter K, Kucherlapati R. Internet-based Support for Bioscience Research: A Collaborative Genome center for Human Chromosome 12. Journal Of The American Medical Informatics Association 1995, 2: 351-364. PMID: 8581551, PMCID: PMC116278, DOI: 10.1136/jamia.1995.96157828.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Artificial, YeastChromosomes, Human, Pair 12Computer Communication NetworksConnecticutData DisplayDatabases, FactualGenetic MarkersGenome, HumanHumansInterinstitutional RelationsLocal Area NetworksModels, GeneticNew York CityOrganizational ObjectivesSoftware DesignSystems IntegrationUser-Computer InterfaceConceptsUser-friendly front endInternet-based supportExternal databasesMedical informaticsGenome CenterGenome informaticsDatabase programMapping communityCandidate mapsInformaticsAssembly toolsAreas of bioscienceFront endDatabaseServerSybaseSuch supportCase studySetToolBioscience researchCertain issuesClientsTechnologySupportThe CEPH Consortium Linkage Map of Human Chromosome 11
Litt M, Kramer P, Kort E, Fain P, Cox S, Root D, White R, Weissenbach J, Donis-Keller H, Gatti R, Weber J, Nakamura Y, Julier C, Hayashi K, Spurr N, Dean M, Mandel J, Kidd K, Kruse T, Retief A, Bale A, Meo T, Vergnaud G, Warren S, Willard H. The CEPH Consortium Linkage Map of Human Chromosome 11. Genomics 1995, 27: 101-112. PMID: 7665156, DOI: 10.1006/geno.1995.1011.Peer-Reviewed Original ResearchApparent monomorphism of ALDH2 in seven American Indian populations
Novoradovsky A, Kidd J, Kidd K, Goldman D. Apparent monomorphism of ALDH2 in seven American Indian populations. Alcohol 1995, 12: 163-167. PMID: 7772269, DOI: 10.1016/0741-8329(94)00086-7.Peer-Reviewed Original ResearchConceptsNew World populationsSouth American Indian populationsALDH2 geneMitochondrial aldehyde dehydrogenaseNorth American populationsALDH2 cDNAALDH2 functionRestriction endonucleasesAldehyde dehydrogenaseConformation polymorphism techniqueSouth American IndiansGenesAllele-specific amplificationAllelesStudied individualsPolymorphism techniquePolymorphismAmerican populationFragmentsAmerican Indian populationsCDNAALDH2EndonucleaseVariantsPopulationAssignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome
Gelernter J, Rao P, Pauls D, Hamblin M, Sibley D, Kidd K. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome. Genomics 1995, 26: 207-209. PMID: 7601444, DOI: 10.1016/0888-7543(95)80202-w.Peer-Reviewed Original ResearchConceptsGenetic linkageSomatic cell hybridsInteresting candidate genesPairwise linkage analysisCell hybridsNovel serotonin receptorCandidate genesChromosome 10Linkage analysisSouthern blotGenesExtended pedigreesLOD scoreReceptor geneLociGenetic polymorphismsHTR7PolymorphismReceptorsLIPED computer programDNALinkageHybridizationNeuropsychiatric disordersPedigreeThe CEPH consortium linkage map of human chromosome 16
Kozman H, Keith T, Donis-keller H, White R, Weissenbach J, Dean M, Vergnaud G, Kidd K, Gusella J, Royle N, Sutherland G, Mulley J. The CEPH consortium linkage map of human chromosome 16. Genomics 1995, 25: 44-58. PMID: 7774955, DOI: 10.1016/0888-7543(95)80108-x.Peer-Reviewed Original ResearchConceptsHuman chromosome 16Genetic mapLinkage mapMap lengthSomatic cell hybrid panelFemale map lengthsChromosome 16Male map lengthFramework genetic mapCell hybrid panelMean genetic distanceSex-averaged mapRestriction enzyme combinationsGenetic distanceAverage heterozygosityEntire chromosomesHybrid panelPhysical mapCEPH consortium linkage mapFamily DNACEPH family DNAsPrimer pairsMarker genotypesLociEnzyme combinationsNetwork-based informatics support of research collaborations in the Human Genome Project and the Human Brain Project.
Miller P, Nadkarni P, Kucherlapati R, Krauter K, Kidd K, Ward D, Shepherd G, Berkowicz D. Network-based informatics support of research collaborations in the Human Genome Project and the Human Brain Project. Medinfo. 1995, 8 Pt 2: 1541-4. PMID: 8591495.Peer-Reviewed Original Research
1994
Linkage Study of a Susceptibility Locus for Schizophrenia in the Pseudoautosomal Region
Barr C, Kennedy J, Pakstis A, Castiglione C, Kidd J, Wetterberg L, Kidd K. Linkage Study of a Susceptibility Locus for Schizophrenia in the Pseudoautosomal Region. Schizophrenia Bulletin 1994, 20: 277-286. PMID: 8085132, DOI: 10.1093/schbul/20.2.277.Peer-Reviewed Original Research
1993
Alleles at the dopamine D4 receptor locus do not contribute to the genetic susceptibility to schizophrenia in a large Swedish kindred
Barr C, Kennedy J, Lichter J, Van Tol H, Wetterberg L, Livak K, Kidd K. Alleles at the dopamine D4 receptor locus do not contribute to the genetic susceptibility to schizophrenia in a large Swedish kindred. American Journal Of Medical Genetics 1993, 48: 218-222. PMID: 8135305, DOI: 10.1002/ajmg.1320480409.Peer-Reviewed Original ResearchConceptsChromosome 11p15.5Receptor geneImperfect direct repeatsDopamine D4 receptor locusD4 receptor geneTyrosine hydroxylase locusDopamine D4 receptor geneSingle haplotypeFirst intronSequence variationCandidate genesG nucleotidesDirect repeatsReceptor locusGenetic markersThird exonLinkage analysisPolymorphic markersGenetic susceptibilityGenesLociClose linkageDRD4 locusAllelesRepeatsAssignment of the norepinephrine transporter protein (NET1) locusto chromosome 16
Gelernter J, Kruger S, Pakstis A, Pacholczyk T, Sparkes R, Kidd K, Amara S. Assignment of the norepinephrine transporter protein (NET1) locusto chromosome 16. Genomics 1993, 18: 690-692. PMID: 7905857, DOI: 10.1016/s0888-7543(05)80375-1.Peer-Reviewed Original ResearchMeSH KeywordsCarrier ProteinsChromosome MappingChromosomes, Human, Pair 16Deoxyribonucleases, Type II Site-SpecificDNA, ComplementaryGenetic LinkageGenetic MarkersHumansNorepinephrineNorepinephrine Plasma Membrane Transport ProteinsPolymorphism, Restriction Fragment LengthRestriction MappingSymportersConceptsNorepinephrine transporter proteinSomatic cell hybrid panelCell hybrid panelHybrid panelHP locusCEPH familiesLarge multigenerational familyTransporter proteinsLinkage analysisChromosome 16Provisional assignmentLinkage dataLociMultigenerational familiesGenetic polymorphismsSite of actionPreliminary assignmentNet1FamilyProteinRFLPSitesPolymorphismPCRLocalizationGenetic and Physical Mapping of the Treacher Collins Syndrome Locus with Respect to Loci in the Chromosome 5q3 Region
Jabs E, Li X, Lovett M, Yamaoka L, Taylor E, Speer M, Coss C, Cadle R, Hall B, Brown K, Kidd K, Dolganov G, Polymeropoulos M, Meyers D. Genetic and Physical Mapping of the Treacher Collins Syndrome Locus with Respect to Loci in the Chromosome 5q3 Region. Genomics 1993, 18: 7-13. PMID: 8276417, DOI: 10.1006/geno.1993.1420.Peer-Reviewed Original ResearchConceptsTCOF1 locusTreacher Collins syndrome locusLinkage analysisHighest maximum lod scorePhysical mapping dataOrder of lociCraniofacial developmental disorderMultipoint linkage analysisGenetic distancePhysical mappingYAC clonesCEPH familiesMaximum lod scoreSyndrome locusLociLOD scoreMapping dataHaplotype analysisTreacher Collins syndromeSyndrome familiesFamilyTCOF1Developmental disordersGenesClones