Analyses of Cross Species Polymerase Chain Reaction Products to Infer the Ancestral State of Human Polymorphisms
Iyengar S, Seaman M, Deinard A, Rosenbaum H, Sirugo G, Castiglione C, Kidd J, Kidd K. Analyses of Cross Species Polymerase Chain Reaction Products to Infer the Ancestral State of Human Polymorphisms. Mitochondrial DNA Part A 1998, 8: 317-327. PMID: 10993602, DOI: 10.3109/10425179809034076.Peer-Reviewed Original ResearchConceptsSingle-strand conformational polymorphismSequence dataUntranslated regionHuman polymorphismsSingle ancestral allelePolymorphic allelesRestriction enzyme sitesAncestral stateExtant populationsGenomic regionsAncestral statusAncestral onesAncestral alleleHuman sequenceHuman allelesStrand conformational polymorphismPCR-RFLPsRestriction fragment length analysisPolymorphic sitesNumerous populationsEnzyme sitesAllelesSpeciesConformational polymorphismPolymerase chain reaction productsEvolution of a D2 Dopamine Receptor Intron Within the Great Apes and Humans
Deinard A, Kidd K. Evolution of a D2 Dopamine Receptor Intron Within the Great Apes and Humans. Mitochondrial DNA Part A 1998, 8: 289-301. PMID: 10993600, DOI: 10.3109/10425179809034074.Peer-Reviewed Original ResearchConceptsDenaturing Gradient Gel ElectrophoresisGenetic variationComparative phylogenetic analysisDNA sequence variationSequence comparative analysisCross-species comparisonsGreat apesEvolutionary relationshipsGradient gel electrophoresisPhylogenetic analysisGeographical rangeSequence variationPygmy chimpanzeesCommon chimpanzeesDNA sequencingDirect DNA sequencingIntronsGel electrophoresisSpeciesChimpanzeesApesSequencingComparative analysisHumansVariation