2004
Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region
Paschou P, Feng Y, Pakstis A, Speed W, DeMille M, Kidd J, Jaghori B, Kurlan R, Pauls D, Sandor P, Barr C, Kidd K. Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region. American Journal Of Human Genetics 2004, 75: 545-560. PMID: 15303240, PMCID: PMC1182043, DOI: 10.1086/424389.Peer-Reviewed Original ResearchMeSH KeywordsC-Reactive ProteinChromosome MappingChromosomes, Human, Pair 17Gene FrequencyGenetic LinkageGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLinkage DisequilibriumLod ScoreMicrosatellite RepeatsMicrotubule-Associated ProteinsNerve Tissue ProteinsPedigreePolymorphism, Single NucleotideTourette SyndromeWhite PeopleConceptsSingle nucleotide polymorphismsLinkage disequilibriumSusceptibility regionsThree-site haplotypesPutative susceptibility regionsBackground linkage disequilibriumSignificant association resultsIndication of linkageNonparametric LOD scoreGenomic regionsThree-marker haplotypeComplex genetic backgroundAdditional microsatellite markersFine mappingGenetic basisHigher LD valuesMicrosatellite markersExpression profilesAssociation resultsTransmission/disequilibrium testChromosome 17Genetic componentGenetic backgroundGenesLOD score
1995
Linkage of congenital, recessive deafness (DFNB4) to chromosome 7q31 and evidence for genetic heterogeneity in the Middle Eastern Druze population
Baldwin C, Weiss S, Farrer L, De Stefano A, Adair R, Franklyn B, Kidd K, Korostishevsky M, Bonné-Tamir B. Linkage of congenital, recessive deafness (DFNB4) to chromosome 7q31 and evidence for genetic heterogeneity in the Middle Eastern Druze population. Human Molecular Genetics 1995, 4: 1637-1642. PMID: 8541853, DOI: 10.1093/hmg/4.9.1637.Peer-Reviewed Original ResearchConceptsHuman chromosome 7q31Genetic linkage analysisNon-syndromic deafnessChromosomal locationGene locationNon-syndromic formsRecessive non-syndromic deafnessLinkage analysisChromosome 7q31Nonallelic mutationsGenetic isolateLarge familyLOD scoreGenetic heterogeneityGenetic causeRecessive deafnessGenesRecognizable phenotypeFirst evidenceDruze familyFamilyAffected individualsSpecific patternsMutationsPhenotypeAssignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome
Gelernter J, Rao P, Pauls D, Hamblin M, Sibley D, Kidd K. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome. Genomics 1995, 26: 207-209. PMID: 7601444, DOI: 10.1016/0888-7543(95)80202-w.Peer-Reviewed Original ResearchConceptsGenetic linkageSomatic cell hybridsInteresting candidate genesPairwise linkage analysisCell hybridsNovel serotonin receptorCandidate genesChromosome 10Linkage analysisSouthern blotGenesExtended pedigreesLOD scoreReceptor geneLociGenetic polymorphismsHTR7PolymorphismReceptorsLIPED computer programDNALinkageHybridizationNeuropsychiatric disordersPedigree
1993
Genetic and Physical Mapping of the Treacher Collins Syndrome Locus with Respect to Loci in the Chromosome 5q3 Region
Jabs E, Li X, Lovett M, Yamaoka L, Taylor E, Speer M, Coss C, Cadle R, Hall B, Brown K, Kidd K, Dolganov G, Polymeropoulos M, Meyers D. Genetic and Physical Mapping of the Treacher Collins Syndrome Locus with Respect to Loci in the Chromosome 5q3 Region. Genomics 1993, 18: 7-13. PMID: 8276417, DOI: 10.1006/geno.1993.1420.Peer-Reviewed Original ResearchConceptsTCOF1 locusTreacher Collins syndrome locusLinkage analysisHighest maximum lod scorePhysical mapping dataOrder of lociCraniofacial developmental disorderMultipoint linkage analysisGenetic distancePhysical mappingYAC clonesCEPH familiesMaximum lod scoreSyndrome locusLociLOD scoreMapping dataHaplotype analysisTreacher Collins syndromeSyndrome familiesFamilyTCOF1Developmental disordersGenesClones
1990
Extensive sequence polymorphisms associated with chromosome 10 alpha satellite DNA and its close linkage to markers from the pericentromeric region
Wu J, Kidd K. Extensive sequence polymorphisms associated with chromosome 10 alpha satellite DNA and its close linkage to markers from the pericentromeric region. Human Genetics 1990, 84: 279-282. PMID: 1968036, DOI: 10.1007/bf00200575.Peer-Reviewed Original ResearchConceptsAlpha satellite DNAExtensive sequence polymorphismSatellite DNAPericentromeric regionSequence polymorphismsExcellent genetic markerCentromeric regionsDNA markersGenetic markersEnzyme PstILOD scoreClose linkagePositive lod scoresLinkage studiesDNAType 2AIndependent supportPolymorphismCentromeresMorphsMarkersRBP3LociDistance relationshipsEcoRV
1987
Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage
Simpson N, Kidd K, Goodfellow P, McDermid H, Myers S, Kidd J, Jackson C, Duncan A, Farrer L, Brasch K, Castiglione C, Genel M, Gertner J, Greenberg C, Gusella J, Holden J, White B. Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage. Nature 1987, 328: 528-530. PMID: 2886918, DOI: 10.1038/328528a0.Peer-Reviewed Original ResearchConceptsRestriction fragment length polymorphismIRBP geneNew DNA markersDifferent restriction fragment length polymorphismsPairwise linkage analysisChromosome 10 markersDNA markersFragment length polymorphismMaximum lod scoreLinkage analysisDisease locusLociMEN2A locusLOD scoreLength polymorphismGenesMultipoint analysisSecondary sitesType 2ADominant fashionKinds of cancersMapping the Wilson disease locus to a cluster of linked polymorphic markers on chromosome 13.
Bowcock A, Farrer L, Cavalli-Sforza L, Hebert J, Kidd K, Frydman M, Bonne-Tamir B. Mapping the Wilson disease locus to a cluster of linked polymorphic markers on chromosome 13. American Journal Of Human Genetics 1987, 41: 27-35. PMID: 3474893, PMCID: PMC1684171.Peer-Reviewed Original ResearchConceptsOrder of markersChromosome 13 markersMultipoint linkage analysisDNA markersRecombination frequencyMaximum lod scoreLinkage analysisPolymorphic markersChromosome 13LOD scoreLociD13S10Esterase DAutosomal recessive disorderWNDCopper metabolismRecessive disorderWilson's diseaseCentimorgansMarkersMetabolismKindreds