2002
The Critical Role of Transmembrane Prolines in Human Prostacyclin Receptor Activation
Stitham J, Martin KA, Hwa J. The Critical Role of Transmembrane Prolines in Human Prostacyclin Receptor Activation. Molecular Pharmacology 2002, 61: 1202-1210. PMID: 11961139, DOI: 10.1124/mol.61.5.1202.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsHuman prostacyclin receptorTransmembrane prolinesMolecular hingeProtein-coupled receptorsVascular smooth muscle relaxationProstacyclin receptor activationAlanine mutationsExtracellular boundarySmooth muscle relaxationPro-89Proline residuesLigand bindingGPCR activationExtracellular locationProper bindingWild-type controlsPosition 89ProlineMuscle relaxationPlatelet aggregationReceptor activationProstacyclin receptorCritical roleBinding
1998
The Orphan Seven-Transmembrane Receptor Apj Supports the Entry of Primary T-Cell-Line-Tropic and Dualtropic Human Immunodeficiency Virus Type 1
Choe H, Farzan M, Konkel M, Martin K, Sun Y, Marcon L, Cayabyab M, Berman M, Dorf M, Gerard N, Gerard C, Sodroski J. The Orphan Seven-Transmembrane Receptor Apj Supports the Entry of Primary T-Cell-Line-Tropic and Dualtropic Human Immunodeficiency Virus Type 1. Journal Of Virology 1998, 72: 6113-6118. PMID: 9621075, PMCID: PMC110417, DOI: 10.1128/jvi.72.7.6113-6118.1998.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus type 1T cell line tropicType 1Peripheral blood mononuclear cellsHIV-1 infectionHIV-1 isolatesBlood mononuclear cellsHIV-1 coreceptorsChemokine receptor CCR5Such coreceptorsMononuclear cellsAsymptomatic stageReceptor APJReceptor CCR5HIV-1Infected individualsCoreceptorAPJTarget cellsInfectionReceptorsViral evolutionSIVmac316Structural interactions between chemokine receptors, gp120 Env and CD4
Choe H, Martin K, Farzan M, Sodroski J, GERARD N, Gerard C. Structural interactions between chemokine receptors, gp120 Env and CD4. Seminars In Immunology 1998, 10: 249-257. PMID: 9653051, DOI: 10.1006/smim.1998.0127.Peer-Reviewed Original ResearchConceptsHIV-1SIV isolatesChemokine receptorsBeta-chemokine receptor CCR5Laboratory-adapted HIV-1Late-stage HIV infectionPrimary HIV-1HIV-1 entryGp120 EnvSIV infectionViral envelope glycoproteinsHIV infectionChronic phaseHIV-2Receptor CCR5SIV virusInfectionEnvelope glycoproteinTransmembrane segment receptorsReceptorsCD4Molecular determinantsDependent sitesHIVCCR5
1997
CD4-Independent Binding of SIV gp120 to Rhesus CCR5
Martin K, Wyatt R, Farzan M, Choe H, Marcon L, Desjardins E, Robinson J, Sodroski J, Gerard C, Gerard N. CD4-Independent Binding of SIV gp120 to Rhesus CCR5. Science 1997, 278: 1470-1473. PMID: 9367961, DOI: 10.1126/science.278.5342.1470.Peer-Reviewed Original ResearchTwo Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection
Farzan M, Choe H, Martin K, Marcon L, Hofmann W, Karlsson G, Sun Y, Barrett P, Marchand N, Sullivan N, Gerard N, Gerard C, Sodroski J. Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection. Journal Of Experimental Medicine 1997, 186: 405-411. PMID: 9236192, PMCID: PMC2198994, DOI: 10.1084/jem.186.3.405.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCD4 AntigensCD4-Positive T-LymphocytesCell LineCloning, MolecularHumansMacaca mulattaMacrophages, AlveolarMolecular Sequence DataReceptors, CCR5Receptors, CytokineReceptors, HIVReceptors, VirusSimian Acquired Immunodeficiency SyndromeSimian immunodeficiency virusConceptsSimian immunodeficiency virusSeven-transmembrane segment receptorsPrimate immunodeficiency virusesImmunodeficiency virusChemokine receptorsMacaque peripheral blood mononuclear cellsRhesus macaque peripheral blood mononuclear cellsSimian immunodeficiency virus (SIV) infectionHuman immunodeficiency virus type 1Peripheral blood mononuclear cellsImmunodeficiency virus type 1Immunodeficiency virus infectionBlood mononuclear cellsHIV-1 variantsChemokine receptor CCR5Central nervous systemCourse of infectionAdditional chemokine receptorsVirus type 1Human alveolar macrophagesMononuclear cellsEntry cofactorReceptor CCR5T lymphocytesVirus infection